pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2022-11-4-28-39pharmjournal-1356Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSДереза: перспективы применения в фармации растительного сырья, содержащего алкалоиды, флавоноиды, полисахариды и другие биологически активные вещества растения семейства пасленовых (Solanaceae) (обзор)Lycium: Prospects of Application in Pharmacy of Plant Raw Materials Containing Alkaloids, Flavonoids, Polysaccharides and Other Biologically Active Substances of the Solanaceae Family Plants (Review)https://orcid.org/0000-0003-0291-6285ТупаБ.TupaB.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

https://orcid.org/0000-0002-0284-419XПотанинаО. Г.PotaninaO. G.

119991, г. Москва, Ленинские горы, д. 1

1, Leninskie gory, Moscow, 119991

https://orcid.org/0000-0003-2147-8348УспенскаяЕ. В.UspenskayaE. V.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

uspenskaya75@mail.ruФГАОУ ВО «Российский университет дружбы народов» (РУДН)РоссияPeoples Friendship University of Russia (RUDN University)Russian FederationФГБОУ ВО «Московский государственный университет имени М. В. Ломоносова» (МГУ имени М. В. Ломоносова)РоссияLomonosov Moscow State UniversityRussian Federation2022241120221142839Copyright © Тупа Б., Потанина О.Г., Успенская Е.В., 20222022Тупа Б., Потанина О.Г., Успенская Е.В.Tupa B., Potanina O.G., Uspenskaya E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/1356Введение

Введение. Обзор посвящен научному анализу состава, свойств и особенностей биологического воздействия на организм человека плодов дерезы, как перспективного растительного сырья для производства новых лекарственных средств.

Текст

Текст. Рассмотрены важнейшие аспекты, связанные с растительным сырьем различных видов дерезы, такие как мировая распространенность растений и унификация многочисленных синонимичных названий сырья, обобщение фармакопейных данных, качественный и количественный состав компонентов Lycium, их структурные особенности, биологические эффекты на жизненно важные системы организма. В обзоре представлена проблема отсутствия в стандартах РФ монографий на сырье растений дерезы, несмотря на существующий и произрастающий на территории РФ растения дерезы русской (Lycium ruthenicum Murray). Этот факт открывает значительные возможности разработки нормативной документации в ГФ РФ на сырье дерезы, в том числе дерезы русской как перспективного ЛРС.

Заключение

Заключение. Полученные результаты демонстрируют потенциальную возможность введения в фармацию нового вида лекарственного растительного сырья и готовых лекарственных препаратов на их основе, а также прогнозировать биологическую активность веществ плодов дерезы и механизмы действия алкалоидов, флавоноидов, полисахаридов и каротиноидов Lycium.

Introduction

Introduction. The review is dedicated to the scientific analysis of the composition, properties and features of the biological effects on the man's organism of the Lycium Fruit as a prospective plant raw material for the production of innovative drugs.

Text

Text. The most important aspects related to plant raw materials of various types of Lycium are considered, such as, the worldwide prevalence of plants and the unification of raw materials numerous synonymous names, the generalization of pharmacopoeia data, the qualitative and quantitative composition of Lycium components, their structural features, biological effects on vital body systems. The review also presents the problem of the absence of general pharmacopoeia monographs on Lycium raw materials in Russia, despite the cultivation of Lyceum ruthenicum M. plants in Russia. This fact opens up significant opportunities to develop the Russian regulatory document for Lycium, as a promising pharmaceutical raw material.

Conclusion

Conclusion. The obtained results demonstrate the potential of introducing into pharmacy a new type of pharmaceutical raw material and a new finished products based on them, as well as predicting the biological activity of the substances of Lycium fruit and mechanisms of alkaloids, flavonoids, polysaccharides and Lycium carotenoids action.

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The authors declare that there are no conflicts of interest present.