<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pharmjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Разработка и регистрация лекарственных средств</journal-title><trans-title-group xml:lang="en"><trans-title>Drug development &amp; registration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-2066</issn><issn pub-type="epub">2658-5049</issn><publisher><publisher-name>LLC «CPHA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33380/2305-2066-2022-11-4(1)-64-67</article-id><article-id custom-type="elpub" pub-id-type="custom">pharmjournal-1397</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACEUTICAL TECHNOLOGY</subject></subj-group></article-categories><title-group><article-title>Изучение влияния технологического режима изготовления водного извлечения из шиповника плодов (Rosae fructus) на содержание аскорбиновой кислоты</article-title><trans-title-group xml:lang="en"><trans-title>Study of the Influence of the Technological Regime of the Production of Water Extraction from Rosehip Fruits (Rosae fructus) on the Content of Ascorbic Acid</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8416-6934</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Собин</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sobin</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614990, г. Пермь, ул. Полевая, д. 2</p></bio><bio xml:lang="en"><p>2, Polevaya str., Perm, 614990</p></bio><email xlink:type="simple">fff-2005@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0129-5245</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелева</surname><given-names>Л. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Korosteleva</surname><given-names>L. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>644099, г. Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>12, Lenina str., Omsk, 644099</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5664-8725</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Луткова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lutkova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614990, Пермь, ул. Букирева, д. 15</p></bio><bio xml:lang="en"><p>15, Bukireva str., Perm, 614990</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8768-860X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дозморова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dozmorova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614990, г. Пермь, ул. Полевая, д. 2</p></bio><bio xml:lang="en"><p>2, Polevaya str., Perm, 614990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Пермская государственная фармацевтическая академия» Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России)<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy" of the Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО «Омский ГМУ» Минздрава России)<country>Россия</country></aff><aff xml:lang="en">Omsk State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГАОУ ВО «Пермский государственный национальный исследовательский университет» (ПГНИУ)<country>Россия</country></aff><aff xml:lang="en">Perm State University (PSU)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>26</day><month>12</month><year>2022</year></pub-date><volume>11</volume><issue>4</issue><issue-title>Приложение 1</issue-title><fpage>64</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Собин Ф.В., Коростелева Л.К., Луткова Т.А., Дозморова Н.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Собин Ф.В., Коростелева Л.К., Луткова Т.А., Дозморова Н.В.</copyright-holder><copyright-holder xml:lang="en">Sobin F.V., Korosteleva L.K., Lutkova T.A., Dozmorova N.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmjournal.ru/jour/article/view/1397">https://www.pharmjournal.ru/jour/article/view/1397</self-uri><abstract><sec><title>Введение</title><p>Введение. COVID-19 признан самой значимой пандемией современной эпохи. Исследования показали потенциальную пользу приема аскорбиновой кислоты в комплексном лечении данного заболевания, особенно у лиц с дефицитом витамина С. Одним из самых популярных и доступных источников введения аскорбиновой кислоты в рацион являются шиповника плоды. Качество водных извлечений из растительного сырья зависит от ряда технологических факторов. Изучение влияния технологического режима изготовления водного извлечения из шиповника плодов на высвобождении аскорбиновой кислоты в полученных лекарственных формах является актуальным.</p></sec><sec><title>Цель</title><p>Цель. Получить различными режимами изготовления водные извлечения из шиповника плодов и изучить влияние технологических параметров на содержание аскорбиновой кислоты.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Объектом исследования явились шиповника плоды в пачках и водные извлечения на их основе, полученные 6 различными способами. Использованы фармакопейные методики, рекомендации производителей, а также термосное настаивание без и с предварительным нагреванием колбы термоса. Для количественного определения аскорбиновой кислоты в полученных водных извлечениях нами использован фармакопейный метод (титрование с 2,6-дихлорфенолиндофенолятом натрия).</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Наименьшее содержание аскорбиновой кислоты отмечено в отваре по фармакопейной методике. Высокие показатели содержания аскорбиновой кислоты отмечены при различных вариантах термосного настаивания шиповника плодов.</p></sec><sec><title>Заключение</title><p>Заключение. Нами получены экстемпоральные водные извлечения шиповника плодов 6 различными режимами экстрагирования. По содержанию аскорбиновой кислоты наиболее эффективным методом получения экстемпорального водного извлечения шиповника плодов является шестичасовое термосное настаивание с предварительным прогревом колбы термоса. Наибольшее количество аскорбиновой кислоты высвобождается при шестичасовом термосном настаивание. В двенадцатичасовых термосных настоях обнаружено уменьшение количества аскорбиновой кислоты. Установлено, что предварительный прогрев колбы термоса приводит к увеличению выхода аскорбиновой кислоты в водное извлечение на 25 %.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. COVID-19 is recognized as the most significant pandemic of the modern era. Studies have shown the potential benefits of taking ascorbic acid in the complex treatment of this disease, especially in people with vitamin C deficiency. One of the most popular and affordable sources of ascorbic acid in the diet are rosehip fruits. The quality of water extracts from plant raw materials depends on a number of technological factors. The study of the influence of the technological regime of the production of water extraction from rosehip fruits on the release of ascorbic acid in the obtained dosage forms is relevant.</p></sec><sec><title>Aim</title><p>Aim. To obtain water extracts from rosehip fruits by various production modes and to study the effect of technological parameters on the content of ascorbic acid.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The object of the study was rosehip fruits in bundles and water extracts based on them, obtained in the 6 different ways. Pharmacopoeial techniques, manufacturers' recommendations, as well as thermos infusion with and without preheating of the thermos flask were used. For quantitative determination of the ascorbic acid in the obtained aqueous extracts, we used the pharmacopoeia method (titration with 2,6-dichlorophenolindophenolate sodium).</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The lowest content of ascorbic acid was noted in the decoction according to the pharmacopoeia method. High levels of ascorbic acid content were noted in the variants of thermos infusion of rosehip fruits.</p></sec><sec><title>Conclusion</title><p>Conclusion. We have obtained extemporal water extracts of rosehip fruits by the 6 different extraction modes. According to the content of ascorbic acid, the most effective method of obtaining extemporal water extraction of rosehip fruits is a six-hour thermos infusion with preheating of the thermos flask. The largest amount of ascorbic acid is released during a six-hour thermos infusion. In the twelve-hour thermos infusions, a decrease in the amount of ascorbic acid was found. It was found that preheating the thermos flask leads to an increase in the yield of ascorbic acid in aqueous extraction by 25 %.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>шиповника плоды</kwd><kwd>водные извлечения</kwd><kwd>аскорбиновая кислота</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rosehip fruits</kwd><kwd>aqueous extracts</kwd><kwd>ascorbic acid</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование проведено при финансовой поддержке Пермского научно-образовательного центра «Рациональное недропользование», 2022 год.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study was carried out with the financial support of the Perm Scientific and Educational Center "Rational Subsoil Use", 2022.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy R. S. N., Batra M. V. N. J., Srivastava S., Syal S. K. Vitamin C and its therapeutic potential in the management of COVID19. Clinical Nutrition ESPEN. 2022;50:8–14. DOI: 10.1016/j.clnesp.2022.05.026.</mixed-citation><mixed-citation xml:lang="en">Reddy R. S. N., Batra M. V. N. J., Srivastava S., Syal S. K. Vitamin C and its therapeutic potential in the management of COVID19. Clinical Nutrition ESPEN. 2022;50:8–14. DOI: 10.1016/j.clnesp.2022.05.026.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Firouzi S., Pahlavani N., Navashenaq J. G., Clayton Z. S. Beigmohammadi M. T., Malekahmadi M. The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients. Clinical Nutrition Open Science. 2022;44:144–154. DOI: 10.1016/j.nutos.2022.06.006.</mixed-citation><mixed-citation xml:lang="en">Firouzi S., Pahlavani N., Navashenaq J. G., Clayton Z. S. Beigmohammadi M. T., Malekahmadi M. The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients. Clinical Nutrition Open Science. 2022;44:144–154. DOI: 10.1016/j.nutos.2022.06.006.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sinnberg T., Lichtensteiger C., Hill-Mündel K., Leischner C., Niessner H., Busch C., Renner O., Wyss N., Flatz L., Lauer U. M., Hoelzle L. E., Nohr D., Burkard M., Marongiu L., Venturelli S. Vitamin C deficiency in blood samples of COVID-19 patients. Antioxidants. 2022;11(8):1580. DOI: 10.3390/antiox11081580.</mixed-citation><mixed-citation xml:lang="en">Sinnberg T., Lichtensteiger C., Hill-Mündel K., Leischner C., Niessner H., Busch C., Renner O., Wyss N., Flatz L., Lauer U. M., Hoelzle L. E., Nohr D., Burkard M., Marongiu L., Venturelli S. Vitamin C deficiency in blood samples of COVID-19 patients. Antioxidants. 2022;11(8):1580. DOI: 10.3390/antiox11081580.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar P., Verma M. K., Sharma R., Agrawal R., Singh S. P., Jaiswal A., Prakash O., Soni N., Verma P., Siddiqui A. H., Gupta S., Sharma P. Immunomodulator vitamin C: an adjuvant therapy in second wave of coronavirus disease 2019. Journal of Pure and Applied Microbiology. 2022;16(3):1465–1478. DOI: 10.22207/JPAM.16.3.46.</mixed-citation><mixed-citation xml:lang="en">Kumar P., Verma M. K., Sharma R., Agrawal R., Singh S. P., Jaiswal A., Prakash O., Soni N., Verma P., Siddiqui A. H., Gupta S., Sharma P. Immunomodulator vitamin C: an adjuvant therapy in second wave of coronavirus disease 2019. Journal of Pure and Applied Microbiology. 2022;16(3):1465–1478. DOI: 10.22207/JPAM.16.3.46.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sargin S. A. Potential anti-influenza effective plants used in Turkish folk medicine: A review. Journal of Ethnopharmacology. 2021;265:113319. DOI: 10.1016/j.jep.2020.113319.</mixed-citation><mixed-citation xml:lang="en">Sargin S. A. Potential anti-influenza effective plants used in Turkish folk medicine: A review. Journal of Ethnopharmacology. 2021;265:113319. DOI: 10.1016/j.jep.2020.113319.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gruenwald J., Uebelhack R., Moré M. I. Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review. Phytomedicine. 2019;60:152958. DOI: 10.1016/j.phymed.2019.152958.</mixed-citation><mixed-citation xml:lang="en">Gruenwald J., Uebelhack R., Moré M. I. Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review. Phytomedicine. 2019;60:152958. DOI: 10.1016/j.phymed.2019.152958.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rahimi M., Sajadimajd S., Mahdian Z., Hemmati M., Malekkhatabi P., Bahrami G., Mohammadi B., Miraghaee S., Hatami R., Mansouri K., Motlagh H. R. M., Keshavarzi S., Derakhshankhah H. Characterization and anti-diabetic effects of the oligosaccharide fraction isolated from Rosa canina in STZ-Induced diabetic rats. Carbohydrate Research. 2020;489:107927. DOI: 10.1016/j.carres.2020.107927.</mixed-citation><mixed-citation xml:lang="en">Rahimi M., Sajadimajd S., Mahdian Z., Hemmati M., Malekkhatabi P., Bahrami G., Mohammadi B., Miraghaee S., Hatami R., Mansouri K., Motlagh H. R. M., Keshavarzi S., Derakhshankhah H. Characterization and anti-diabetic effects of the oligosaccharide fraction isolated from Rosa canina in STZ-Induced diabetic rats. Carbohydrate Research. 2020;489:107927. DOI: 10.1016/j.carres.2020.107927.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Turan, I., Demir, S., Kilinc, K., Yaman S. O., Misir S., Kara H., Genc B., Mentese A., Aliyazicioglu, Y., Deger О. Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression. Journal of Pharmaceutical Analysis. 2018;8(6):394–399. DOI: 10.1016/j.jpha.2017.12.005.</mixed-citation><mixed-citation xml:lang="en">Turan, I., Demir, S., Kilinc, K., Yaman S. O., Misir S., Kara H., Genc B., Mentese A., Aliyazicioglu, Y., Deger О. Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression. Journal of Pharmaceutical Analysis. 2018;8(6):394–399. DOI: 10.1016/j.jpha.2017.12.005.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kilinc K., Demir S., Turan I., Mentese A., Orem A., Sonmez M., Aliyazicioglu Y. Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells. Nutrition and Cancer. 2020;72(2):273–282. DOI: 10.1080/01635581.2019.1625936.</mixed-citation><mixed-citation xml:lang="en">Kilinc K., Demir S., Turan I., Mentese A., Orem A., Sonmez M., Aliyazicioglu Y. Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells. Nutrition and Cancer. 2020;72(2):273–282. DOI: 10.1080/01635581.2019.1625936.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Milala J., Piekarska-Radzik L., Sójka M., Klewicki R., Matysiak B., Klewicka E. Rosa spp. Extracts as a factor that limits the growth of staphylococcus spp. bacteria, a food contaminant. Molecules. 2021;26(15):4590. DOI: 10.3390/molecules26154590.</mixed-citation><mixed-citation xml:lang="en">Milala J., Piekarska-Radzik L., Sójka M., Klewicki R., Matysiak B., Klewicka E. Rosa spp. Extracts as a factor that limits the growth of staphylococcus spp. bacteria, a food contaminant. Molecules. 2021;26(15):4590. DOI: 10.3390/molecules26154590.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
