Введение

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

10.33380/2305-2066-2023-12-2-34-43

pharmjournal-1480

Research Article

ПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ

RESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTS

Применение наночастиц селена в онкологии (обзор)

Application of Selenium Nanoparticles in Oncology (Review)

https://orcid.org/0000-0002-5353-7739

Духновский

Е. А.

Dukhnovsky

E. A.

117198, г. Москва, ул. Миклухо-Маклая, д. 10/2

10/2, Mikluho-Maklaya str., Moscow, 117198

eadukh@mail.ru

Институт биохимической технологии и нанотехнологии РУДН (ИБХТН)Institute of Biochemical Technology and Nanotechnology, RUDN University

2023

27052023

1223443

2023

Духновский Е.А.

Dukhnovsky E.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/1480

Введение

Введение. За последнее время под влиянием стремительного развития нанотехнологий, все большее внимание к использованию в биомедицинских целях, в частности для лечения онкологических заболеваний, привлекают наночастицы селена благодаря своим особым физико-химическим свойствам. В обзоре рассмотрены наночастицы селена, которые широко исследуются в области онкологии.

Текст

Текст. Данный обзор посвящен анализу научной литературы по исследованию противораковой активности наночастиц селена в отношении клеточных линий рака человека, а также по исследованию их в качестве системы доставки противоопухолевых препаратов. Кроме этого, обсуждаются механизмы противоопухолевой активности наночастиц селена в отношении злокачественных новообразований.

Заключение

Заключение. В результате проведенного анализа литературных данных установлено, что наночастицы селена демонстрируют весьма неплохое противоопухолевое действие в отношении различных клеточных линий рака человека. Показано, что противоопухолевая активность наночастиц селена преимущественно связана с индукцией внешних и внутренних сигнальных путей апоптоза, который приводит к гибели раковых клеток. Также наночастицы селена являются перспективными системами для доставки разных противоопухолевых препаратов, обеспечивая высокую эффективность и биодоступность лекарственных средств в опухолевые клетки, а также низкую токсичность в отношении здоровых клеток.

Introduction

Introduction. Due to the rapid development of nanotechnology, selenium nanoparticles (NPs) have recently attracted much attention due to their unique physical and chemical properties for biomedical applications, in particular for the treatment of oncological diseases. The review considers the selenium nanoparticles, which are widely studied in the field of oncology.

Text

Text. This review is devoted to the analysis of scientific literature on the anticancer activity of selenium nanoparticles against human cancer cell lines, as well as the application of these nanoparticles as a drug delivery system. Besides, the antitumor mechanisms of selenium nanoparticles against malignant neoplasms are discussed.

Conclusion

Conclusion. According to the results of literary data analysis, it was found that selenium nanoparticles exhibit a good antitumor effect against various human cancer cell lines. It is shown that the antitumor activity of selenium nanoparticles is mainly related to activation of the extrinsic and intrinsic signaling pathways of apoptosis leading to cancer cell death. Also, selenium nanoparticles are promising systems for delivery of various anticancer drugs, providing high efficiency, bioavailability of drugs in tumor cells and minimizing toxicity to healthy cells.

наночастицы селенапротивораковая активностьсистема доставки лекарствцитотоксичностьапоптоз

selenium nanoparticlesanticancer activitydrug delivery systemcytotoxicityapoptosis

Публикация подготовлена при поддержке Программы стратегического академического лидерства Российского университета дружбы народов.

This publication has been prepared with the support of the Peoples' Friendship University of Russia Strategic Academic Leadership Program.

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The authors declare that there are no conflicts of interest present.