Введение

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

10.33380/2305-2066-2023-12-2-44-54

pharmjournal-1481

Research Article

ПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ

RESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTS

Обзор производных пиперидина и морфолина как перспективные источники биологически активных соединений (обзор)

Overview of Piperidine and Morpholine Derivatives as Promising Sources of Biologically Active Compounds (Review)

https://orcid.org/0000-0001-7978-1468

Хамитова

А. Е.

Khamitova

A. E.

050012, г. Алматы, ул. Толе би, д. 94

94, str. Tole bi, Almaty, 050012

khamitova.a@kaznmu.kz

https://orcid.org/0000-0003-2534-9367

Берилло

Д. А.

Berillo

D. A.

050012, г. Алматы, ул. Толе би, д. 94

94, str. Tole bi, Almaty, 050012

Некоммерческое акционерное общество «Казахский национальный медицинский университет имени С. Д. Асфендиярова»Asfendiyarov Kazakh National Medical University

2023

27052023

1224454

2023

Хамитова А.Е., Берилло Д.А.

Khamitova A.E., Berillo D.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/1481

Введение

Введение. Поиск новых, эффективных и безопасных фармакологически активных веществ остается актуальной задачей в области фармации. Множество соединений ряда пиперидина, морфолина широко используются в медицинской практике и относятся к важной группе биологически активных соединений. Проведен информационный, литературный поиск по синтезу новых производных пиперидина и морфолина. В статье обобщены результаты исследований новых производных пиперидина и морфолина как потенциальных источников биологически активных веществ.

Текст

Текст. Обзор посвящен взаимосвязи между фармакологической активностью N-производных пиперидина и морфолина в отношении различных биологических мишеней и структурой вещества, подчеркивается важность пиперидинового и морфолинового кольца в дизайне и разработке лекарственных препаратов. Пиперидин и морфолин рассматриваются как прерогативные структуры не только для повышения активности, но и для получения биологических веществ с желаемыми терапевтическими свойствами и улучшенной фармакокинетикой.

Заключение

Заключение. Литературный обзор показывает текущую тенденцию в отношении изучения производных морфолина и пиперидина, раскрывает их высокую фармакофорную активность. Обзор предоставит исследователям необходимую базу знаний для внесения химических структурных изменений в структуры лекарств лидеров для усиления фармакологических активностей.

Introduction

Introduction. The search for new, effective and safe pharmacologically active substances remains an urgent task in the field of pharmacy. Many compounds of the piperidine and morpholine series are widely used in medical practice and belong to an important group of biologically active compounds. An informational, literature search on the synthesis of new derivatives of piperidine and morpholine was carried out. The article summarizes the results of studies of new derivatives of piperidine and morpholine as potential sources of biologically active substances.

Text

Text. The review is devoted to the relationship between the pharmacological activity of the N-derivatives of piperidine and morpholine in relation to various biological targets and the structure of the substance, the importance of the piperidine and morpholine rings in the design and development of drugs is highlighted. Piperidine and morpholine are considered as prerogative structures not only for increasing activity, but also for obtaining biological substances with desired therapeutic properties and improved pharmacokinetics.

Conclusion

Conclusion. The literature review shows the current trend towards the study of morpholine and piperidine derivatives, reveals their high pharmacophore activity. The review will provide researchers with the necessary knowledge base to make chemical structural changes to the structures of drug leaders to enhance pharmacological activities.

пиперидинморфолингетероциклыфармакофорсинтезбиологическая активностьразработка

piperidinemorpholineheterocyclespharmacophoresynthesisbiological activitydevelopment

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The authors declare that there are no conflicts of interest present.