References

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

pharmjournal-159

Research Article

ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИЯ

PHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGY

ТЕХНОЛОГИИ ПОВЫШЕНИЯ СТАБИЛЬНОСТИ ПОЛИФЕНОЛЬНЫХ СОЕДИНЕНИЙ В ЛЕКАРСТВЕННЫХ ПРЕПАРАТАХ (ОБЗОР)

TECHNOLOGIES TO IMPROVE THE STABILITY OF POLYPHENOLIC COMPOUNDS IN DRUG DISCOVERY (REVIEW)

Соловьёва

Н. Л.

Solovieva

N. L.

119991, г. Москва, ул. Трубецкая, 8

noemail@neicon.ru

Сокуренко

М. С.

Sokurenko

M. S.

119991, г. Москва, ул. Трубецкая, 8;

109240, г. Москва, Устьинский проезд, 2/14

sokmary@mail.ru

ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»I.M. Sechenov First Moscow State Medical University

ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»; ФГБУН «ФИЦ питания и биотехнологии»I.M. Sechenov First Moscow State Medical University; Scientific Research Institute of Nutrition

2016

09012019

048291

2019

Соловьёва Н.Л., Сокуренко М.С.

Solovieva N.L., Sokurenko M.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/159

Природные полифенолы представляют собой ценные соединения, которые обладают свойствами связывать свободные радикалы и образовывать комплексы с белками. Поэтому фенольные соединения привлекают все большее внимание как потенциальные средства для профилактики и лечения многих окислительных стресс-зависимых заболеваний, таких как сердечно-сосудистые заболевания, рак, старение, диабет и нейродегенеративные заболевания. Полифенольные соединения характеризуются очень высокой чувствительностью к некоторым экологическим факторам, включая физические, химические и биологические, и могут очень быстро окисляться со значительной потерей активности. Разработка новых подходов к стабилизации и защите этих соединений от разрушения и, следовательно, для улучшения их биологической активности представляет интерес. В литературе описаны различные методы инкапсуляции, многие из которых были успешно использованы для растительных полифенолов. В этом обзоре представлены некоторые растительные полифенолы, их основные химические и биологические свойства, а также методы инкапсуляции полифенолов, которые подразделяются на физические, физико-химические, химические и другие методы стабилизации.

Natural polyphenols are valuable compounds possessing scavenging properties towards radical oxygen species, and complexing properties towards proteins. Therefore, phenolic compounds have attracted increasing attention as potential agents for preventing and treating many oxidative stress-related diseases, such as cardiovascular diseases, cancer, ageing, diabetes mellitus and neurodegenerative diseases. Polyphenolic compounds are characterized by a very high sensitivity to several environmental factors including physical, chemical and biological conditions and can be oxidized very quickly with a considerable loss in activity. Development of new approaches to stabilisation and protection of these compounds from degradation and therefore to improve their biological activity is of interest. The literature describes many encapsulation methods, many of which have been successfully used for plant polyphenols. This review provides some plant polyphenols and their basic chemical and biological properties as well as methods of encapsulating polyphenols, which are divided into physical, physico-chemical, chemical methods and other methods of stabilization.

полифенолыантиоксидантбиодоступностьинкапсуляция

polyphenolantioxidantbioavailabilityencapsulation

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The authors declare that there are no conflicts of interest present.