pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-169Research ArticleЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ЛЕКАРСТВЕННЫХ СРЕДСТВDRUG PRODUCTS EFFICACY AND SAFETYРЕТРОСПЕКТИВА РАЗВИТИЯ НАУКИ О РАСТВОРЕНИИ ТВЁРДЫХ ДОЗИРОВАННЫХ ЛЕКАРСТВЕННЫХ ФОРМ (ОБЗОР)RETROSPECTIVE OF DISSOLUTION TEST OF SOLID DOSAGE FORMS (REVIEW)ГребёнкинД. Ю.GrebenkinD. Yu.gredmitrij93@gmail.comСтанишевскийЯ. М.StanishevskiyYa. M.noemail@neicon.ruШохинИ. Е.ShohinI. E.noemail@neicon.ruМалашенкоЕ. А.MalashenkoE. A.noemail@neicon.ruФГАОУ ВО «Российский университет дружбы народов»Peoples' Friendship University of RussiaООО «Центр фармацевтической аналитики»Center of Pharmaceutical Analytics LtdФГБОУ ВО Первый МГМУ им. И.М.Сеченова Минздрава РоссииI.M. Sechenov First Moscow State Medical University20160901201904158166Copyright © Гребёнкин Д.Ю., Станишевский Я.М., Шохин И.Е., Малашенко Е.А., 20192019Гребёнкин Д.Ю., Станишевский Я.М., Шохин И.Е., Малашенко Е.А.Grebenkin D.Y., Stanishevskiy Y.M., Shohin I.E., Malashenko E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/169

Работа освещает основные исторические вехи в развитии науки о растворении лекарственных препаратов и сравнительного теста кинетики растворения от первых экспериментальных работ в области растворения твёрдых веществ в начале двадцатого века, осознания тесной взаимосвязи растворения и биодоступности лекарственных препаратов в 1950-х годах, создания первых аппаратов для растворения до введения процедуры «биовейвер», основанной на БКС.

The article describes the main historical stages in the development of the science of drug dissolution and the dissolution profile test from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the introduction of biowaiver based on the BCS.

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The authors declare that there are no conflicts of interest present.