pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2024-13-1-1462pharmjournal-1736Research ArticleФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯPHARMACEUTICAL TECHNOLOGYАктуальность разработки стоматологического in situ имплантата для применения в пострезекционной терапии (обзор)Relevance of the Development of Dental In situ Implant for Post-resection Therapy (Review)https://orcid.org/0000-0002-6380-1302ПомыткинаМ. В.PomytkinaM. V.

119571, г. Москва, просп. Вернадского, д. 96, корп. 1

96/1, Vernadsky av., Moscow, 119571

mary.pom99@gmail.comhttps://orcid.org/0000-0001-8695-0346БахрушинаЕ. О.BakhrushinaE. O.

119571, г. Москва, просп. Вернадского, д. 96, корп. 1

96/1, Vernadsky av., Moscow, 119571

https://orcid.org/0000-0003-4870-6232СахароваП. С.SakharovaP. S.

119571, г. Москва, просп. Вернадского, д. 96, корп. 1

96/1, Vernadsky av., Moscow, 119571

https://orcid.org/0009-0009-8688-6079КоногороваП. Д.KonogorovaP. D.

119571, г. Москва, просп. Вернадского, д. 96, корп. 1

96/1, Vernadsky av., Moscow, 119571

https://orcid.org/0000-0003-4307-8791ДеминаН. Б.DeminaN. B.

119571, г. Москва, просп. Вернадского, д. 96, корп. 1

96/1, Vernadsky av., Moscow, 119571

Институт фармации им. А. П. Нелюбина Первого Московского государственного медицинского университета им. И. М. Сеченова Минздрава России (Сеченовского Университета)РоссияA. P. Nelyubin Institute of Pharmacy. I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation2024020220241318194Copyright © Помыткина М.В., Бахрушина Е.О., Сахарова П.С., Коногорова П.Д., Демина Н.Б., 20242024Помыткина М.В., Бахрушина Е.О., Сахарова П.С., Коногорова П.Д., Демина Н.Б.Pomytkina M.V., Bakhrushina E.O., Sakharova P.S., Konogorova P.D., Demina N.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/1736Введение

Введение. Проблема обезболивания после хирургического вмешательства актуальна в современной стоматологии, так как контроль над болью является важной частью лечения. Помимо обезболивания, существуют и другие проблемы пострезекционной терапии – кровотечение из раны, воспалительный процесс. Современная стоматологическая практика не располагает системой направленной доставки или медицинским изделием анальгезирующего, противовоспалительного, анестезирующего или кровоостанавливающего действия, обеспечивающими высокую приверженность пациентов проводимой пострезекционной терапии.

Текст

Текст. Для решения данной проблемы может быть предложена разработка системы in situ, а именно имплантата – лекарственной формы, формирующейся непосредственно в месте введения, в альвеолярной лунке. Такая система направленной доставки обладает сразу несколькими преимуществами, к которым можно отнести: отсутствие необходимости в применении перевязочного медицинского материала; отсутствие риска вторичной контаминации; точность дозирования и таргетность доставки в локус поражения; высокую мукоадгезию системы к месту нанесения; длительность высвобождения активного ингредиента и другие. Целью обзора является обоснование возможности и актуальности разработки новой системы в форме in situ имплантата для применения в стоматологической пострезекционной практике. Исследование проводилось по основным базам публикаций (Scopus, Web of Science, PubMed и другие), а также в базе данных патентного поиска по материалам, опубликованным за период с 2000 года по настоящее время. В ходе исследования были описаны существующие на данный момент in situ системы для решения стоматологических проблем, которые могли бы служить прототипом систем для доставки обезболивающего вещества непосредственно в лунку зуба; полимеры, использующиеся для их создания и возможности высвобождения лекарственных веществ; а также приводится характеристика существующих лекарственных форм, применяющихся как местно, так и для оказания системного действия с целью обезболивания, в сравнении с системами in situ, которые имеют определенные достоинства и большой потенциал для развития.

Заключение

Заключение. По результатам работы сделано заключение о возможности проведения фармацевтической разработки имплантатов in situ для стоматологического применения, а также выделены наиболее перспективные полимеры для осуществления фазового перехода в альвеолярной лунке.

Introduction

Introduction. The problem of pain relief after surgery is relevant in modern dentistry, as pain control is an important part of treatment. In addition to anesthesia, there are other problems of post-resection therapy such as bleeding from the wound and inflammation. Modern dental practice does not have a targeted delivery system or a medical product with analgesic, anti-inflammatory, anesthetic or hemostatic action, which ensures high adherence of patients to the ongoing post-resection therapy.

Text

Text. To solve this problem, it can be proposed to develop an in situ implant – a dosage form that is formed directly at the injection site, in the alveolar socket. Targeted delivery system has advantages: no need to use a medical dressing material; no risk of secondary contamination; dosing accuracy and target delivery to the lesion locus; high mucoadhesion to the site of application; the duration of the active ingredient release and others. The purpose of the review is to substantiate the possibility and relevance of developing a new in situ implant system for use in dental post-resection practice. The study was conducted on the main databases of publications (Scopus, Web of Science, PubMed and others), and patent search database on materials published from 2000 to the present. The study describes the currently existing in situ systems for dental problems, which could be a prototype of systems for delivering an anesthetic directly to the tooth socket, the polymers used to create them and the possibility of releasing drugs, and also characterizes existing drugs for the pain relief (applied both locally and for systemic action), in comparison with in situ systems, which have certain advantages and great potential for development.

Conclusion

Conclusion. Based on the results of the work, a conclusion about the possibility of pharmaceutical development of dental in situ implants was made, and the most promising polymers for phase transition in the alveolar socket were identified.

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The authors declare that there are no conflicts of interest present.