pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2024-13-2-1617pharmjournal-1815Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSИзучение потенциала фенхеля обыкновенного (Foeniculum vulgare Mill.) как ценного лекарственного растения (обзор)Exploring the potential of fennel (Foeniculum vulgare Mill.) as a valuable medicinal plant: a comprehensive (review)https://orcid.org/0009-0009-4421-5373БуракбаС.BourakbaS.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

bourakba.safa93@gmail.comhttps://orcid.org/0000-0003-4442-9266МараховаА. И.MarakhovaA. I.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

agentcat85@mail.ruhttps://orcid.org/0000-0002-0387-397XСтанишевскийЯ. М.StanishevskiyYa. M.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

https://orcid.org/0000-0002-3135-1917ВасиленкоИ. А.VasilenkoI. A.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

https://orcid.org/0000-0001-7916-5913ЖилкинаВ. Ю.ZhilkinaV. Y.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН)Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University)2024080520241325967Copyright © Буракба С., Марахова А.И., Станишевский Я.М., Василенко И.А., Жилкина В.Ю., 20242024Буракба С., Марахова А.И., Станишевский Я.М., Василенко И.А., Жилкина В.Ю.Bourakba S., Marakhova A.I., Stanishevskiy Y.M., Vasilenko I.A., Zhilkina V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/1815Введение

Введение. Foeniculum vulgare Mill., широко известный как фенхель обыкновенный или укроп аптечный, весьма распространен как одно из старейших в мире пряных растений, имеющих существенное экономическое значение и нашедших широкое применение в фармацевтической промышленности. В медицинской практике используются главным образом плоды данного растения, которые включены в Государственную фармакопею XIV издания и являются источником эфирного масла. Применяются в виде настоя в качестве спазмолитического и ветрогонного средства. В пищу используется трава фенхеля, собранная до цветения, а также плоды, стебли и соцветия растения – в качестве приправы.

Текст

Текст. Целью этого исследования является обобщение научных трудов о морфологических характеристиках, фитохимических соединениях, терапевтических свойствах и основных механизмах фармакологической активности F. vulgare. Был проведен систематический поиск литературы с использованием релевантных ключевых слов, таких как «фенхель», «Foeniculum vulgare Mill.», «терапевтический» и «фармакология», в известных базах данных, включая ScienceDirect, Scopus, EBSCO и Medline. Поиск охватывал статьи, опубликованные до 25 апреля 2023 года в доступных журналах. Результаты исследования показали, что фенхель обладает широким спектром фармакологических свойств, включая антиоксидантное, противораковое, противовоспалительное, противогрибковое, антибактериальное и эстрогенное действие. Эти эффекты можно объяснить присутствием ароматических соединений, в частности анетола, эстрагола и фенхона, которые в изобилии содержатся в фенхеле.

Заключение

Заключение. Разнообразные фармакологические свойства и богатый химический состав фенхеля делают его перспективным сырьем для разработки новых лекарственных препаратов. Дальнейшее изучение терапевтического потенциала фенхеля с помощью исследований in vivo и in vitro будет способствовать установлению механизмов фармакологического действия биологически активных веществ (БАВ) фенхеля.

Introduction

Introduction. Foeniculum vulgare Mill., commonly known as fennel or drugstore dill, is very common as one of the world's oldest spice plants, which has significant economic importance and wide application in the pharmaceutical industry. In medical practice, the fruits of this plant are mainly used, which are included in the State Pharmacopoeia of the XIV edition and are a source of essential oil. They are used as an antispasmodic and carminative agent in the form of an infusion. Fennel grass harvested before flowering is used for food, as well as fruits, stems and inflorescences of the plant as a seasoning.

Text

Text. The purpose of this study is to summarize scientific papers on the morphological characteristics, phytochemical compounds, therapeutic properties and basic mechanisms of pharmacological activity of F. vulgare. A systematic literature search was conducted using relevant keywords such as "fennel", "Foeniculum vulgare Mill.", "therapeutic" and "pharmacology" in well-known databases, including ScienceDirect, Scopus, EBSCO and Medline. The search covered articles published before April 25, 2023 in available journals. The results of the study showed that fennel has a wide range of pharmacological properties, including antioxidant, anti-cancer, anti-inflammatory, antifungal, antibacterial and estrogenic effects. These effects can be explained by the presence of aromatic compounds, in particular anethole, estragole and fenchone, which are abundantly present in fennel.

Conclusion

Conclusion. The diverse pharmacological properties and rich chemical composition of fennel make it a promising raw material for the development of new medicines. Further study of the therapeutic potential of fennel through in vivo and in vitro studies will contribute to the establishment of mechanisms of pharmacological action of biologically active substances (BAS) of fennel.

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The authors declare that there are no conflicts of interest present.