pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2024-13-4-1867pharmjournal-1955Research ArticleФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯPHARMACEUTICAL TECHNOLOGYЛипосомы – метаболически активные транспортные системы лекарственных средств: классификация, составные компоненты, способы изготовления и стабилизации. Часть 1 (обзор)Liposomes – metabolically active drug transport systems: classification, components, preparation methods, and stabilization. Part 1 (review)https://orcid.org/0000-0003-2074-3832ОсочукС. С.OsochukS. S.

210009, г. Витебск, пр-т Фрунзе, д. 27

27, Frunze avenue, Vitebsk, 210009

https://orcid.org/0000-0001-9292-4240КоцурЮ. М.KotsurYu. M.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

uliya.kocur@spcpu.ruhttps://orcid.org/0000-0003-1061-0665ПожарицкаяО. Н.PozharitskayaO. N.

183038, г. Мурманск, ул. Владимирская, д. 17

17, Vladimirskaya str., Murmansk, 183038

https://orcid.org/0000-0001-8077-2462ФлисюкЕ. В.FlisyukE. V.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0002-0013-4784СмеховаИ. Е.SmekhovaI. E.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0009-0002-5678-672XМалковС. Д.MalkovS. D.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0009-0001-1190-5839ЗарифиК. О.ZarifiK. O.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0002-1343-4663ТитовичИ. А.TitovichI. A.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0001-7785-4256КрасоваЕ. К.KrasovaE. K.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0003-4351-0695ШиковА. Н.ShikovA. N.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

Учреждение образования «Витебский государственный ордена Дружбы народов медицинский университет»БеларусьVitebsk State Order of Peoples' Friendship Medical UniversityBelarusФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)РоссияSaint-Petersburg State Chemical and Pharmaceutical UniversityRussian FederationФедеральное государственное бюджетное учреждение науки Мурманский морской биологический институт Российской академии наук (ММБИ РАН)РоссияMurmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS)Russian Federation2024251020241346077Copyright © Осочук С.С., Коцур Ю.М., Пожарицкая О.Н., Флисюк Е.В., Смехова И.Е., Малков С.Д., Зарифи К.О., Титович И.А., Красова Е.К., Шиков А.Н., 20242024Осочук С.С., Коцур Ю.М., Пожарицкая О.Н., Флисюк Е.В., Смехова И.Е., Малков С.Д., Зарифи К.О., Титович И.А., Красова Е.К., Шиков А.Н.Osochuk S.S., Kotsur Y.M., Pozharitskaya O.N., Flisyuk E.V., Smekhova I.E., Malkov S.D., Zarifi K.O., Titovich I.A., Krasova E.K., Shikov A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/1955Введение

Введение. В данном обзоре рассмотрены вопросы современной классификации липосом, методов их изготовления, стабилизации и роли составных компонентов, визуализации, фармакокинетики. В первой части обсуждены первые три вышеупомянутых аспекта.

Текст

Текст. Липосомы являются не только перспективными наноконтейнерами для адресной доставки лекарственных средств, но и метаболически активными комплексами с широким спектром активности. Липидные компоненты липосом могут оказать выраженное действие на органы и ткани-мишени. Продукты метаболизма основных компонентов липосом обладают собственной биологической активностью, зависящей от их сочетания и дозировки. Все вышесказанное свидетельствует о перспективности использования липосом не только в качестве носителей ЛС, но и в качестве самостоятельных эффекторов, способных оказать значительное влияние на метаболизм человека при различных заболеваниях. Проведено сравнение преимуществ и ограничений методов получения липосом, рассмотрены особенности изготовления стелс-липосом. Отдельно обсуждены вопросы стабилизации липосом.

Заключение

Заключение. Обсужденная в обзоре информация может быть полезна при разработке лекарственных средств в форме липосом.

Introduction

Introduction. This review article is focused on the modern classification of liposomes, preparation methods, stabilization and the role of structural components, visualization, and pharmacokinetics. Part 1 discusses the first three aspects mentioned above.

Text

Text. Depending on the size and number of bilayers, liposomes are classified into simple, long-circulating, cationic, immuno-liposomes, and sterically stabilized. The lipid components of liposomes can have a pronounced effect on target organs and tissues. Metabolites of the main components of liposomes have their biological activity, depending on their combination and dosage. All of the above indicates the promise of using liposomes not only as carriers of drugs but also as independent effectors that can have a significant impact on human metabolism in various diseases. The advantages and limitations of methods for preparing liposomes, and the features for manufacturing stealth liposomes are discussed. A special section of the article is dedicated to liposome stabilization.

Conclusions

Conclusions. The information discussed in the review article may be useful in the development of pharmaceutical formulations in liposomes. Liposomes are not only promising nanocontainers for targeted drug delivery, but also metabolically active complexes with a wide spectrum of activity.

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The authors declare that there are no conflicts of interest present.