pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2024-13-4-1871pharmjournal-1956Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSАктуализация сведений о микозах и противогрибковых препаратах для поиска эффективных платформ для производства новых соединений тиазоловUpdating information of mycoses and antifungal medicines to find effective platforms for the production of new thiazole compoundshttps://orcid.org/0009-0000-1539-8013ЧерныхТ. Ф.ChernykhT. F.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

tatiana.odegova@pharminnotech.comhttps://orcid.org/0000-0002-4492-6599БогдановаО. Ю.BogdanovaO. Yu.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0001-8077-2462ФлисюкЕ. В.FlisyukE. V.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0001-9292-4240КоцурЮ. М.KozurYu. M.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0002-7573-1719СидоровК. О.SidorovK. O.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

https://orcid.org/0000-0002-5483-6626НаркевичИ. А.NarkevichI. A.

197022, г. Санкт-Петербург, ул. Профессора Попова, 14, литера А

14A, Prof. Popova str., Saint-Petersburg, 197022

Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)РоссияSaint-Petersburg State Chemical and Pharmaceutical UniversityRussian Federation2024251020241342744Copyright © Черных Т.Ф., Богданова О.Ю., Флисюк Е.В., Коцур Ю.М., Сидоров К.О., Наркевич И.А., 20242024Черных Т.Ф., Богданова О.Ю., Флисюк Е.В., Коцур Ю.М., Сидоров К.О., Наркевич И.А.Chernykh T.F., Bogdanova O.Y., Flisyuk E.V., Kozur Y.M., Sidorov K.O., Narkevich I.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/1956Введение

Введение. Сведения о микозах и противогрибковых препаратах современного типа зачастую носят отрывочный, несистематизированный характер, что требует корректировки.

Цель

Цель. Систематизировать новейшие сведения о грибах и микозах, средствах борьбы с ними и встречаемых на этом пути проблемах, осветить последние достижения в области синтеза и исследования активности 1,2,4-триазола как потенциального фунгицидного соединения.

Материалы и методы

Материалы и методы. Материалами служили опубликованные в передовых научных журналах исследования авторов, проведенные по всему миру, в области изучения грибов, противогрибковых препаратов, поиска новых противогрибковых средств.

Результаты и обсуждение

Результаты и обсуждение. В статье представлен обзор современных сведений о морфобиологических особенностях грибов, актуализации их таксономии и номенклатуры, показана роль грибов в природе и развитии грибковых инфекций у человека и животных, структурированы сведения о классификации микозов и их возбудителях. Также приведены новейшие сведения о фармакологических свойствах основных существующих на настоящее время противогрибковых препаратов, механизмах формирования устойчивости к ним у грибов; в сравнительном аспекте с другими группами противомикотических препаратов показана перспективность азолов и их производных в качестве источников получения новых фунгицидных лекарственных и дезинфицирующих средств. Литературные исследования показали, что производные 1,2,4-триазола обладают широким спектром противогрибковой активности, которая распространяется и на другие виды активности.

Заключение

Заключение. Значительная перспективность триазолов обусловлена в том числе и фунгицидным влиянием в отношении устойчивых штаммов грибов – возбудителей инфекций человека и животных. Преимуществом новых производных является и низкий уровень подавляющих грибы концентраций, низкая цитотоксичность, что позволяет в перспективе использовать их для внутривенного введения. Актуализация сведений о действенности новых противогрибковых соединений поможет исследователям систематизировать знания о свойствах азолов, что может способствовать поиску и разработке новых потенциальных кандидатов на противогрибковые препараты с высокой эффективностью и селективностью, способствовать формированию новых направлений исследований по поиску эффективных средств борьбы с микозами в различных сферах деятельности человека.

Introduction

Introduction. Information about mycoses and antifungal drugs of the modern type is often fragmentary and unsystematic, which requires correction.

Aim

Aim. To systematize the latest information about fungi and mycoses, means of combating them and the problems encountered along the way, to highlight the latest achievements in the field of synthesis and research of the activities of 1,2,4-triazole as a potential fungicidal compound.

Materials and methods

Materials and methods. The materials were the authors' research published in advanced scientific journals, conducted around the world in the field of studying fungi, antifungal drugs, and the search for new antifungal agents.

Results and discussion

Results and discussion. The article provides an overview of current information on the morphobiological features of fungi, updating their taxonomy and nomenclature, shows the role of fungi in nature and the development of fungal infections in humans and animals, structured information on the classification of mycoses and their pathogens. The latest information is also provided on the pharmacological properties of the main currently existing antifungal drugs, the mechanisms of formation of resistance to them in fungi, in a comparative aspect with other groups of antimycotic drugs, the prospects of azoles and their derivatives as new fungicidal drugs and disinfectants are shown. Literature studies have shown that 1,2,4-triazole derivatives have a wide range of antifungal activity, which extends to other types of activity.

Conclusion

Conclusion. It was noted that the significant prospects of triazoles are due, among other things, to the fungicidal effect on resistant strains of fungi-pathogens of human and animal infections. The advantage of the new derivatives is the low level of concentrations suppressing fungi, low cytotoxicity, which allows them to be used for intravenous administration in the future. Updating information on the effectiveness of new antifungal compounds will help researchers systematize knowledge about the properties of azoles, which can contribute to the search and development of new potential candidates for antifungal drugs with high efficiency and selectivity, and contribute to the formation of new research directions for the search for effective means of combating mycoses in various fields of human activity.

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The authors declare that there are no conflicts of interest present.