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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pharmjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Разработка и регистрация лекарственных средств</journal-title><trans-title-group xml:lang="en"><trans-title>Drug development &amp; registration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-2066</issn><issn pub-type="epub">2658-5049</issn><publisher><publisher-name>LLC «CPHA»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33380/2305-2066-2024-13-4-1820</article-id><article-id custom-type="elpub" pub-id-type="custom">pharmjournal-1960</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДОКЛИНИЧЕСКИЕ И КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRECLINICAL AND CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Влияние кетогенной диеты на липидный профиль у пациентов с сахарным диабетом второго типа</article-title><trans-title-group xml:lang="en"><trans-title>The effect of the keto diet on lipid profile with type two diabetic patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6770-4964</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гассан</surname><given-names>Фадва</given-names></name><name name-style="western" xml:lang="en"><surname>Ghassan</surname><given-names>Fadwa</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Эрбиль</p></bio><bio xml:lang="en"><p>Erbil</p></bio><email xlink:type="simple">fadwa.ghassan@cue.edu.krd</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-9347-2729</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мохаммед</surname><given-names>Атека</given-names></name><name name-style="western" xml:lang="en"><surname>Mohammed</surname><given-names>Ateka</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Эрбиль</p></bio><bio xml:lang="en"><p>Erbil</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-0810-084X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казим</surname><given-names>Зейнаб</given-names></name><name name-style="western" xml:lang="en"><surname>Kazim</surname><given-names>Zainab</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Эрбиль</p></bio><bio xml:lang="en"><p>Erbil</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Эрбильский Католический университет. Фармацевтический колледж. Отделение клинической фармации</institution></aff><aff xml:lang="en"><institution>Clinical pharmacy department. Pharmacy college. Catholic University of Erbil</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2024</year></pub-date><volume>13</volume><issue>4</issue><fpage>202</fpage><lpage>211</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гассан Ф., Мохаммед А., Казим З., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гассан Ф., Мохаммед А., Казим З.</copyright-holder><copyright-holder xml:lang="en">Ghassan F., Mohammed A., Kazim Z.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmjournal.ru/jour/article/view/1960">https://www.pharmjournal.ru/jour/article/view/1960</self-uri><abstract><sec><title>Введение</title><p>Введение. Сахарный диабет 2 типа (СД2) входит в число наиболее распространенных заболеваний и основных причин смертности среди населения развитых стран. Это серьезная проблема общественного здравоохранения, и значимость ее растет: согласно оценкам, к 2025 году количество пациентов, страдающих этим заболеванием, превысит 380 миллионов.</p></sec><sec><title>Цель</title><p>Цель. Оценка влияния кетогенных диет на гликемический контроль пациентов с СД 2 типа в провинциях Киркук и Мосул.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. С 01.09.2022 г. по 01.04.2023 г. в городах Мосул и Киркук проводилось исследование с целью оценки влияния кетогенной диеты (кетодиеты) на изменение уровня HbA1c и липидного профиля у пациентов с СД2.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Исследование выявило следующее распределение пациентов по полу и возрасту: пациенты женского пола составили 46,3 %, мужского – 56,7 % от общего количества пациентов, при этом доля пациентов в возрасте старше 56 лет составила 30 % среди женщин и 60,7 % среди мужчин. Р-значение в оценке изменений уровня HbA1C до и после применения кетодиеты оказалось существенным (0.0001), так же как и в оценке изменений липидного профиля до и после проведения кетодиеты (0.001); в отношении общего уровня глицеридов p-значение также было существенным и достигало величины 0.002. Принимая во внимание большие размеры частиц ЛПНП, нами была выдвинута гипотеза о том, что возникновение кардиоваскулярных проблем вследствие повышения уровня ХС ЛПНП маловероятно. Для людей с диабетом второго типа кетогенная диета с очень низким содержанием углеводов (VLCKD) (менее 50 г в день) является безопасным, легко переносимым и широко признанным видом диетотерапии, помогающим изменить образ жизни и поведенческие привычки в течение четырех месяцев при применении в сочетании с интервенционной программой по снижению веса.</p></sec><sec><title>Заключение</title><p>Заключение. Прослеживается хорошо заметная связь между кетогенной диетой и такими показателями больных сахарным диабетом, как уровень HbA1c и липидный профиль. Предполагается проведение дальнейших исследований с увеличением числа пациентов и продолжительности наблюдения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. In the developed world, among the main causes of disease and death is type 2 diabetes. It is a significant public health issue with rising prevalence, with more than 380 million patients estimated to be affected by 2025.</p></sec><sec><title>Aim</title><p>Aim. To evaluate the effect of ketogenic diets on glycemic control in patients with type II DM in Kirkuk and Mosul provinces.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Patients with T2DM in both Mosul and Kirkuk cities were enrolled in this study to evaluate the effect of keto diet on HbA1c level and Lipid profile variations between 1/9/2022 to 1/4/2023.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. This study shows that the distributions of patients according to age and gender there was about 43.3 % female and 56.7 % male and the age variations, female with age above 56 years old was 30 % while male 60.7 %. A significant p value was shown in HbA1C variations before and after keto diet (0.0001), also in lipid profile of a significant p value before and after keto diet (0.001) regarding total Glyceride a significant p value highly was (0.002). Due to the large particle size of LDL-C, it has been hypothesized that this elevation in LDL-C would not likely cause cardiovascular problems. For individuals with type 2 diabetes, the low-calorie-ketogenic VLCK diet (&lt;50 g of carbohydrates per day) is a safe, well-tolerated, and recognized medical nutritional therapy option when used in conjunction with an interventional weight loss program that offers support for lifestyle and behavioral modification over a 4-month period.</p></sec><sec><title>Conclusion</title><p>Conclusion. Diabetic and ketogenic diet there is a good clear relationship regarding the HbA1c and lipid profile. Further studies are required for larger numbers of patients and longer duration follow up.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>СД2</kwd><kwd>VLCKD</kwd><kwd>HbA1c</kwd><kwd>ХС ЛПНП</kwd></kwd-group><kwd-group xml:lang="en"><kwd>T2DM</kwd><kwd>VLCK</kwd><kwd>HbA1c</kwd><kwd>LDL-C</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tahrani A. A., Piya M. K., Kennedy A., Barnett A. H. Glycaemic control in type 2 diabetes: targets and new therapies. Pharmacology &amp; Therapeutics. 2010;125(2):328–361. DOI: 10.1016/j.pharmthera.2009.11.001.</mixed-citation><mixed-citation xml:lang="en">Tahrani A. A., Piya M. K., Kennedy A., Barnett A. H. Glycaemic control in type 2 diabetes: targets and new therapies. Pharmacology &amp; Therapeutics. 2010;125(2):328–361. DOI: 10.1016/j.pharmthera.2009.11.001.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sapra A., Bhandari P. Diabetes mellitus. Treasure Island: StatPearls. 2022.</mixed-citation><mixed-citation xml:lang="en">Sapra A., Bhandari P. Diabetes mellitus. Treasure Island: StatPearls. 2022.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Roglic G. WHO Global report on diabetes: a summary. International Journal of Noncommunicable Diseases. 2016;1(1):3–8. DOI: 10.4103/2468-8827.184853.</mixed-citation><mixed-citation xml:lang="en">Roglic G. WHO Global report on diabetes: a summary. International Journal of Noncommunicable Diseases. 2016;1(1):3–8. DOI: 10.4103/2468-8827.184853.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Davies M. J., Aroda V. R., Collins B. S., Gabbay R. A., Green J., Maruthur N. M., Rosas S. E., Del Prato S., Mathieu C., Mingrone G., Rossing P., Tankova T., Tsapas A., Buse J. B. Management of hyperglycemia in type 2 diabetes. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care. 2022;45(11):2753–2786. DOI: 10.2337/dci22-0034.</mixed-citation><mixed-citation xml:lang="en">Davies M. J., Aroda V. R., Collins B. S., Gabbay R. A., Green J., Maruthur N. M., Rosas S. E., Del Prato S., Mathieu C., Mingrone G., Rossing P., Tankova T., Tsapas A., Buse J. B. Management of hyperglycemia in type 2 diabetes. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care. 2022;45(11):2753–2786. DOI: 10.2337/dci22-0034.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Riddle M. C., Cefalu W. T., Evans P. H., Gerstein H. C., Nauck M. A., Oh W. K., Rothberg A. E., le Roux C. W., Rubino F., Schauer P., Taylor R., Twenefour D. Consensus report: definition and interpretation of remission in type 2 diabetes. Diabetes Care. 2021;44(10):2438–2444. DOI: 10.2337/dci21-0034.</mixed-citation><mixed-citation xml:lang="en">Riddle M. C., Cefalu W. T., Evans P. H., Gerstein H. C., Nauck M. A., Oh W. K., Rothberg A. E., le Roux C. W., Rubino F., Schauer P., Taylor R., Twenefour D. Consensus report: definition and interpretation of remission in type 2 diabetes. Diabetes Care. 2021;44(10):2438–2444. DOI: 10.2337/dci21-0034.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Boye K. S., Thieu V. T., Lage M. J., Miller H., Paczkowski R. The association between sustained HbA1c control and long-term complications among individuals with type 2 diabetes: a retrospective study. Advances in Therapy. 2022;39:2208–2221. DOI: 10.1007/s12325-022-02106-4.</mixed-citation><mixed-citation xml:lang="en">Boye K. S., Thieu V. T., Lage M. J., Miller H., Paczkowski R. The association between sustained HbA1c control and long-term complications among individuals with type 2 diabetes: a retrospective study. Advances in Therapy. 2022;39:2208–2221. DOI: 10.1007/s12325-022-02106-4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Taheri S., Zaghloul H., Chagoury O., Elhadad S., Ahmed S. H., El Khatib N., Amona R. A., El Nahas K., Suleiman N., Alnaama A., Al-Hamaq A., Charlson M., Wells M. T., Al-Abdulla S., Abou-Samra A. B. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. The Lancet Diabetes &amp; Endocrinology. 2020;8(6):477–489. DOI: 10.1016/S2213-8587(20)30117-0.</mixed-citation><mixed-citation xml:lang="en">Taheri S., Zaghloul H., Chagoury O., Elhadad S., Ahmed S. H., El Khatib N., Amona R. A., El Nahas K., Suleiman N., Alnaama A., Al-Hamaq A., Charlson M., Wells M. T., Al-Abdulla S., Abou-Samra A. B. Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial. The Lancet Diabetes &amp; Endocrinology. 2020;8(6):477–489. DOI: 10.1016/S2213-8587(20)30117-0.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lean M. E. J., Leslie W. S., Barnes A. C., Brosnahan N., Thom G., McCombie L., Peters C., Zhyzhneuskaya S., Al-Mrabeh A., Hollingsworth K. G., Rodrigues A. M., Rehackova L., Adamson A. J., Sniehotta F. F., Mathers J. C., Ross H. M., McIlvenna Y., Welsh P., Kean S., Ford I., McConnachie A., Messow C.-M., Sattar N., Taylor R. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes &amp; Endocrinology. 2019;7:344–355. DOI: 10.1016/S2213-8587(19)30068-3.</mixed-citation><mixed-citation xml:lang="en">Lean M. E. J., Leslie W. S., Barnes A. C., Brosnahan N., Thom G., McCombie L., Peters C., Zhyzhneuskaya S., Al-Mrabeh A., Hollingsworth K. G., Rodrigues A. M., Rehackova L., Adamson A. J., Sniehotta F. F., Mathers J. C., Ross H. M., McIlvenna Y., Welsh P., Kean S., Ford I., McConnachie A., Messow C.-M., Sattar N., Taylor R. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes &amp; Endocrinology. 2019;7:344–355. DOI: 10.1016/S2213-8587(19)30068-3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Pan X.-F., Chen J., Xia L., Cao A., Zhang Y., Wang J., Li H., Yang K., Guo K., He M., Pan A. Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia. 2020;63:21–33. DOI: 10.1007/s00125-019-04985-9.</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Pan X.-F., Chen J., Xia L., Cao A., Zhang Y., Wang J., Li H., Yang K., Guo K., He M., Pan A. Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia. 2020;63:21–33. DOI: 10.1007/s00125-019-04985-9.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Guess N. D. Could dietary modification independent of energy balance influence the underlying pathophysiology of type 2 diabetes? Implications for type 2 diabetes remission. Diabetes Therapy. 2022;13:603–617. DOI: 10.1007/s13300-022-01220-4.</mixed-citation><mixed-citation xml:lang="en">Guess N. D. Could dietary modification independent of energy balance influence the underlying pathophysiology of type 2 diabetes? Implications for type 2 diabetes remission. Diabetes Therapy. 2022;13:603–617. DOI: 10.1007/s13300-022-01220-4.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nyenwe E. A., Jerkins T. W., Umpierrez G. E., Kitabchi A. E. Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism. 2011;60(1):1–23. DOI: 10.1016/j.metabol.2010.09.010.</mixed-citation><mixed-citation xml:lang="en">Nyenwe E. A., Jerkins T. W., Umpierrez G. E., Kitabchi A. E. Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism. 2011;60(1):1–23. DOI: 10.1016/j.metabol.2010.09.010.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Paoli A., Rubini A., Volek J. S., Grimaldi K. A. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition. 2013;67(8):789–796. DOI: 10.1038/ejcn.2013.116.</mixed-citation><mixed-citation xml:lang="en">Paoli A., Rubini A., Volek J. S., Grimaldi K. A. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition. 2013;67(8):789–796. DOI: 10.1038/ejcn.2013.116.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Paoli A. Ketogenic diet for obesity: friend or foe? International Journal of Environmental Research and Public Health. 2014;11(2):2092–2107. DOI: 10.3390/ijerph110202092.</mixed-citation><mixed-citation xml:lang="en">Paoli A. Ketogenic diet for obesity: friend or foe? International Journal of Environmental Research and Public Health. 2014;11(2):2092–2107. DOI: 10.3390/ijerph110202092.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schwingshackl L., Hoffmann G. Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: a systematic review and meta-analysis. Journal of the Academy of Nutrition and Dietetics. 2013;113(12):1640–1661. DOI: 10.1016/j.jand.2013.07.010.</mixed-citation><mixed-citation xml:lang="en">Schwingshackl L., Hoffmann G. Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: a systematic review and meta-analysis. Journal of the Academy of Nutrition and Dietetics. 2013;113(12):1640–1661. DOI: 10.1016/j.jand.2013.07.010.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson A. A., Seimon R. V., Lee C. M. Y., Ayre J., Franklin J., Markovic T. P., Caterson I. D., Sainsbury A. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. Obesity Reviews. 2015;16(1):64–76. DOI: 10.1111/obr.12230.</mixed-citation><mixed-citation xml:lang="en">Gibson A. A., Seimon R. V., Lee C. M. Y., Ayre J., Franklin J., Markovic T. P., Caterson I. D., Sainsbury A. Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. Obesity Reviews. 2015;16(1):64–76. DOI: 10.1111/obr.12230.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dashti H. M., Mathew T. C., Hussein T., Asfar S. K., Behbahani A., Khoursheed M. A., Al-Sayer H. M., Bo-Abbas Y. Y., Al-Zaid N. S. Long-term effects of a ketogenic diet in obese patients. Experimental &amp; Clinical Cardiology. 2004;9(3):200–205.</mixed-citation><mixed-citation xml:lang="en">Dashti H. M., Mathew T. C., Hussein T., Asfar S. K., Behbahani A., Khoursheed M. A., Al-Sayer H. M., Bo-Abbas Y. Y., Al-Zaid N. S. Long-term effects of a ketogenic diet in obese patients. Experimental &amp; Clinical Cardiology. 2004;9(3):200–205.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kossoff E. H., Zupec-Kania B. A., Rho J. M. Ketogenic diets: an update for child neurologists. Journal of Child Neurology. 2009;24:979–988. DOI: 10.1177/0883073809337162.</mixed-citation><mixed-citation xml:lang="en">Kossoff E. H., Zupec-Kania B. A., Rho J. M. Ketogenic diets: an update for child neurologists. Journal of Child Neurology. 2009;24:979–988. DOI: 10.1177/0883073809337162.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">D’Andrea-Meira I., Romão T. T., Pires do Prado H. J., Kruger L. T., Paiva Pires M. E., da Conceição P. O. Ketogenic diet and epilepsy: what we know so far. Frontiers in Neuroscience. 2019;13:5. DOI: 10.3389/fnins.2019.00005.</mixed-citation><mixed-citation xml:lang="en">D’Andrea-Meira I., Romão T. T., Pires do Prado H. J., Kruger L. T., Paiva Pires M. E., da Conceição P. O. Ketogenic diet and epilepsy: what we know so far. Frontiers in Neuroscience. 2019;13:5. DOI: 10.3389/fnins.2019.00005.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Evert A. B., Dennison M., Gardner C. D., Garvey W. T., Lau K. H. K., MacLeod J., Mitri J., Pereira R. F., Rawlings K., Robinson S., Saslow L., Uelmen S., Urbanski P. B., Yancy W. S. Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care. 2019;42(5):731–754. DOI: 10.2337/dci19-0014.</mixed-citation><mixed-citation xml:lang="en">Evert A. B., Dennison M., Gardner C. D., Garvey W. T., Lau K. H. K., MacLeod J., Mitri J., Pereira R. F., Rawlings K., Robinson S., Saslow L., Uelmen S., Urbanski P. B., Yancy W. S. Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care. 2019;42(5):731–754. DOI: 10.2337/dci19-0014.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor R., Holman R. R. Normal weight individuals who develop type 2 diabetes: the personal fat threshold. Clinical Science. 2015;128(7):405–410. DOI: 10.1042/CS20140553.</mixed-citation><mixed-citation xml:lang="en">Taylor R., Holman R. R. Normal weight individuals who develop type 2 diabetes: the personal fat threshold. Clinical Science. 2015;128(7):405–410. DOI: 10.1042/CS20140553.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kirkpatrick C. F., Bolick J. P., Kris-Etherton P. M., Sikand G., Aspry K. E., Soffer D. E., Willard K.-E., Maki K. C. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. Journal of Clinical Lipidology. 2019;13(5):689–711.e1. DOI: 10.1016/j.jacl.2019.08.003.</mixed-citation><mixed-citation xml:lang="en">Kirkpatrick C. F., Bolick J. P., Kris-Etherton P. M., Sikand G., Aspry K. E., Soffer D. E., Willard K.-E., Maki K. C. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. Journal of Clinical Lipidology. 2019;13(5):689–711.e1. DOI: 10.1016/j.jacl.2019.08.003.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Singh M., Hung E. S., Cullum A., Allen R. E., Aggett P. J., Dyson P., Forouhi N. G., Greenwood D. C., Pryke R., Taylor R., Twenefour D., Waxman R., Young I. S. Lower carbohydrate diets for adults with type 2 diabetes. Diabetic Medicine. 2022;39(3):e14674. DOI: 10.1111/dme.14674.</mixed-citation><mixed-citation xml:lang="en">Singh M., Hung E. S., Cullum A., Allen R. E., Aggett P. J., Dyson P., Forouhi N. G., Greenwood D. C., Pryke R., Taylor R., Twenefour D., Waxman R., Young I. S. Lower carbohydrate diets for adults with type 2 diabetes. Diabetic Medicine. 2022;39(3):e14674. DOI: 10.1111/dme.14674.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Brown A., McArdle P., Taplin J., Unwin D., Unwin J., Deakin T., Wheatley S., Murdoch C., Malhotra A., Mellor D. Dietary strategies for remission of type 2 diabetes: a narrative review. Journal of Human Nutrition and Dietetics. 2022;35(1):165–178. DOI: 10.1111/jhn.12938.</mixed-citation><mixed-citation xml:lang="en">Brown A., McArdle P., Taplin J., Unwin D., Unwin J., Deakin T., Wheatley S., Murdoch C., Malhotra A., Mellor D. Dietary strategies for remission of type 2 diabetes: a narrative review. Journal of Human Nutrition and Dietetics. 2022;35(1):165–178. DOI: 10.1111/jhn.12938.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Roekenes J., Martins C. Ketogenic diets and appetite regulation. Current Opinion in Clinical Nutrition &amp; Metabolic Care. 2021;24(4):359–363. DOI: 10.1097/MCO.0000000000000760.</mixed-citation><mixed-citation xml:lang="en">Roekenes J., Martins C. Ketogenic diets and appetite regulation. Current Opinion in Clinical Nutrition &amp; Metabolic Care. 2021;24(4):359–363. DOI: 10.1097/MCO.0000000000000760.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Westerterp-Plantenga M. S., Lemmens S. G., Westeterp K. R. Dietary protein – its role in satiety, energetics, weight loss and health. British Journal of Nutrition. 2012;108(S2):S105–S112. DOI: 10.1017/S0007114512002589.</mixed-citation><mixed-citation xml:lang="en">Westerterp-Plantenga M. S., Lemmens S. G., Westeterp K. R. Dietary protein – its role in satiety, energetics, weight loss and health. British Journal of Nutrition. 2012;108(S2):S105–S112. DOI: 10.1017/S0007114512002589.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Nymo S., Coutinho S. R., Jørgensen J., Rehfeld J. F., Truby H., Kulseng B., Martins C. Timeline of changes in appetite during weight loss with a ketogenic diet. International Journal of Obesity. 2017;41:1224–1231. DOI: 10.1038/ijo.2017.96.</mixed-citation><mixed-citation xml:lang="en">Nymo S., Coutinho S. R., Jørgensen J., Rehfeld J. F., Truby H., Kulseng B., Martins C. Timeline of changes in appetite during weight loss with a ketogenic diet. International Journal of Obesity. 2017;41:1224–1231. DOI: 10.1038/ijo.2017.96.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lambrechts D. A. J. E., Brandt-Wouters E., Verschuure P., Vles H. S. H., Majoie M. J. M. A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet. Epilepsy Research. 2016;127:87–92. DOI: 10.1016/j.eplepsyres.2016.08.014.</mixed-citation><mixed-citation xml:lang="en">Lambrechts D. A. J. E., Brandt-Wouters E., Verschuure P., Vles H. S. H., Majoie M. J. M. A prospective study on changes in blood levels of cholecystokinin-8 and leptin in patients with refractory epilepsy treated with the ketogenic diet. Epilepsy Research. 2016;127:87–92. DOI: 10.1016/j.eplepsyres.2016.08.014.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chearskul S., Delbridge E., Shulkes A., Proietto J., Kriketos A. Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. The American Journal of Clinical Nutrition. 2008;87(5):1238–1246. DOI: 10.1093/ajcn/87.5.1238.</mixed-citation><mixed-citation xml:lang="en">Chearskul S., Delbridge E., Shulkes A., Proietto J., Kriketos A. Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. The American Journal of Clinical Nutrition. 2008;87(5):1238–1246. DOI: 10.1093/ajcn/87.5.1238.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Marchiò M., Roli L., Lucchi C., Costa A. M., Borghi M., Iughetti L., Trenti T., Guerra A., Biagini G. Ghrelin plasma levels after 1 year of ketogenic diet in children with refractory epilepsy. Frontiers in Nutrition. 2019;6:112. DOI: 10.3389/fnut.2019.00112.</mixed-citation><mixed-citation xml:lang="en">Marchiò M., Roli L., Lucchi C., Costa A. M., Borghi M., Iughetti L., Trenti T., Guerra A., Biagini G. Ghrelin plasma levels after 1 year of ketogenic diet in children with refractory epilepsy. Frontiers in Nutrition. 2019;6:112. DOI: 10.3389/fnut.2019.00112.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Stubbs B. J., Cox P. J., Evans R. D., Cyranka M., Clarke K., de Wet H. A ketone ester drink lowers human ghrelin and appetite. Obesity. 2018;26(2):269–273. DOI: 10.1002/oby.22051.</mixed-citation><mixed-citation xml:lang="en">Stubbs B. J., Cox P. J., Evans R. D., Cyranka M., Clarke K., de Wet H. A ketone ester drink lowers human ghrelin and appetite. Obesity. 2018;26(2):269–273. DOI: 10.1002/oby.22051.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Accurso A., Bernstein R. K., Dahlqvist A., Draznin B., Feinman R. D., Fine E. J., Gleed A., Jacobs D. B., Larson G., Lustig R. H., Manninen A. H., McFarlane S. I., Morrison K., Nielsen J. V., Ravnskov U., Roth K. S., Silvestre R., Sowers J. R., Sundberg R., Volek J. S., Westman E. C., Wood R. J., Wortman J., Vernon M. C. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutrition &amp; Metabolism. 2008;5:9. DOI: 10.1186/1743-7075-5-9.</mixed-citation><mixed-citation xml:lang="en">Accurso A., Bernstein R. K., Dahlqvist A., Draznin B., Feinman R. D., Fine E. J., Gleed A., Jacobs D. B., Larson G., Lustig R. H., Manninen A. H., McFarlane S. I., Morrison K., Nielsen J. V., Ravnskov U., Roth K. S., Silvestre R., Sowers J. R., Sundberg R., Volek J. S., Westman E. C., Wood R. J., Wortman J., Vernon M. C. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutrition &amp; Metabolism. 2008;5:9. DOI: 10.1186/1743-7075-5-9.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Westman E. C., Tondt J., Maguire E., Yancy W. S. Jr. Implementing a low-carbohydrate, ketogenic diet to manage type 2 diabetes mellitus. Expert Review of Endocrinology &amp; Metabolism. 2018;13(5):263–272. DOI: 10.1080/17446651.2018.1523713.</mixed-citation><mixed-citation xml:lang="en">Westman E. C., Tondt J., Maguire E., Yancy W. S. Jr. Implementing a low-carbohydrate, ketogenic diet to manage type 2 diabetes mellitus. Expert Review of Endocrinology &amp; Metabolism. 2018;13(5):263–272. DOI: 10.1080/17446651.2018.1523713.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gershuni V. M., Yan S. L., Medici V. Nutritional ketosis for weight management and reversal of metabolic syndrome. Current Nutrition Reports. 2018;7(3):97–106. DOI: 10.1007/s13668-018-0235-0.</mixed-citation><mixed-citation xml:lang="en">Gershuni V. M., Yan S. L., Medici V. Nutritional ketosis for weight management and reversal of metabolic syndrome. Current Nutrition Reports. 2018;7(3):97–106. DOI: 10.1007/s13668-018-0235-0.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sacks F. M., Bray G. A., Carey V. J., Smith S. R., Ryan D. H., Anton S. D., McManus K., Champagne C. M., Bishop L. M., Laranjo N., Leboff M. S., Rood J. C., de Jonge L., Greenway F. L., Loria C. M., Obarzanek E., Williamson D. A. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. New England Journal of Medicine. 2009;360(9):859–873. DOI: 10.1056/NEJMoa0804748.</mixed-citation><mixed-citation xml:lang="en">Sacks F. M., Bray G. A., Carey V. J., Smith S. R., Ryan D. H., Anton S. D., McManus K., Champagne C. M., Bishop L. M., Laranjo N., Leboff M. S., Rood J. C., de Jonge L., Greenway F. L., Loria C. M., Obarzanek E., Williamson D. A. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. New England Journal of Medicine. 2009;360(9):859–873. DOI: 10.1056/NEJMoa0804748.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Samaha F. F., Iqbal N., Seshadri P., Chicano K. L., Daily D. A., McGrory J., Williams T., Williams M., Gracely E. J., Stern L. A low-carbohydrate as compared with a low-fat diet in severe obesity. New England Journal of Medicine. 2003;348:2074-2081. DOI: 10.1056/NEJMoa022637.</mixed-citation><mixed-citation xml:lang="en">Samaha F. F., Iqbal N., Seshadri P., Chicano K. L., Daily D. A., McGrory J., Williams T., Williams M., Gracely E. J., Stern L. A low-carbohydrate as compared with a low-fat diet in severe obesity. New England Journal of Medicine. 2003;348:2074-2081. DOI: 10.1056/NEJMoa022637.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Stern L., Iqbal N., Seshadri P., Chicano K. L., Daily D. A., McGrory J., Williams M., Gracely E. J., Samaha F. F. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Annals of Internal Medicine. 2004;140(10):778–785. DOI: 10.7326/0003-4819-140-10-200405180-00007.</mixed-citation><mixed-citation xml:lang="en">Stern L., Iqbal N., Seshadri P., Chicano K. L., Daily D. A., McGrory J., Williams M., Gracely E. J., Samaha F. F. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Annals of Internal Medicine. 2004;140(10):778–785. DOI: 10.7326/0003-4819-140-10-200405180-00007.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Gannon M. C., Nuttall F. Q. Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes. 2004;53(9):2375–2382. DOI: 10.2337/diabetes.53.9.2375.</mixed-citation><mixed-citation xml:lang="en">Gannon M. C., Nuttall F. Q. Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes. 2004;53(9):2375–2382. DOI: 10.2337/diabetes.53.9.2375.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Boden G., Sargrad K., Homko C., Mozzoli M., Stein T. P. Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Annals of Internal Medicine. 2005;142(6):403–411. DOI: 10.7326/0003-4819-142-6-200503150-00006.</mixed-citation><mixed-citation xml:lang="en">Boden G., Sargrad K., Homko C., Mozzoli M., Stein T. P. Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Annals of Internal Medicine. 2005;142(6):403–411. DOI: 10.7326/0003-4819-142-6-200503150-00006.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Feinman R. D., Pogozelski W. K., Astrup A., Bernstein R. K., Fine E. J., Westman E. C., Accurso A., Frassetto L., Gower B. A., McFarlane S. I., Nielsen J. V., Krarup T., Saslow L., Roth K. S., Vernon M. C., Volek J. S., Wilshire G. B., Dahlqvist A., Sundberg R., Childers A., Morrison K., Manninen A. H., Dashti H. M., Wood R. J., Wortman J., Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015;31(1):1–13. DOI: 10.1016/j.nut.2014.06.011.</mixed-citation><mixed-citation xml:lang="en">Feinman R. D., Pogozelski W. K., Astrup A., Bernstein R. K., Fine E. J., Westman E. C., Accurso A., Frassetto L., Gower B. A., McFarlane S. I., Nielsen J. V., Krarup T., Saslow L., Roth K. S., Vernon M. C., Volek J. S., Wilshire G. B., Dahlqvist A., Sundberg R., Childers A., Morrison K., Manninen A. H., Dashti H. M., Wood R. J., Wortman J., Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015;31(1):1–13. DOI: 10.1016/j.nut.2014.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Farrés J., Pujol A., Coma M., Ruiz J. L., Naval J., Mas J. M., Molins A., Fondevila J., Aloy P. Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet. Nutrition &amp; Metabolism. 2010:7:88. DOI: 10.1186/1743-7075-7-88.</mixed-citation><mixed-citation xml:lang="en">Farrés J., Pujol A., Coma M., Ruiz J. L., Naval J., Mas J. M., Molins A., Fondevila J., Aloy P. Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet. Nutrition &amp; Metabolism. 2010:7:88. DOI: 10.1186/1743-7075-7-88.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Goday A., Bellido D., Sajoux I., Crujeiras A. B., Burguera B., García-Luna P. P., Oleaga A., Moreno B., Casanueva F. F. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutrition &amp; Diabetes. 2016;6(9):e230. DOI: 10.1038/nutd.2016.36.</mixed-citation><mixed-citation xml:lang="en">Goday A., Bellido D., Sajoux I., Crujeiras A. B., Burguera B., García-Luna P. P., Oleaga A., Moreno B., Casanueva F. F. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus. Nutrition &amp; Diabetes. 2016;6(9):e230. DOI: 10.1038/nutd.2016.36.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Sharman M. J., Kraemer W. J., Love D. M., Avery N. G., Gómez A. L., Scheett T. P., Volek J. S. A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men. The Journal of Nutrition. 2002;132:1879–1885. DOI: 10.1093/jn/132.7.1879.</mixed-citation><mixed-citation xml:lang="en">Sharman M. J., Kraemer W. J., Love D. M., Avery N. G., Gómez A. L., Scheett T. P., Volek J. S. A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men. The Journal of Nutrition. 2002;132:1879–1885. DOI: 10.1093/jn/132.7.1879.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Volek J. S., Sharman M. J., Gómez A. L., Scheett T. P., Kraemer W. J. An isoenergetic very low carbohydrate diet improves serum HDL cholesterol and triacylglycerol concentrations, the total cholesterol to HDL cholesterol ratio and postprandial pipemic responses compared with a low fat diet in normal weight, normolipidemic women. The Journal of Nutrition. 2003;133(9):2756–2761. DOI: 10.1093/jn/133.9.2756.</mixed-citation><mixed-citation xml:lang="en">Volek J. S., Sharman M. J., Gómez A. L., Scheett T. P., Kraemer W. J. An isoenergetic very low carbohydrate diet improves serum HDL cholesterol and triacylglycerol concentrations, the total cholesterol to HDL cholesterol ratio and postprandial pipemic responses compared with a low fat diet in normal weight, normolipidemic women. The Journal of Nutrition. 2003;133(9):2756–2761. DOI: 10.1093/jn/133.9.2756.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Volek J. S., Gómez A. L., Kraemer W. J. Fasting lipoprotein and postprandial triacylglycerol responses to a low-carbohydrate diet supplemented with n-3 fatty acids. Journal of the American College of Nutrition. 2000;19(3):383–391. DOI: 10.1080/07315724.2000.10718935.</mixed-citation><mixed-citation xml:lang="en">Volek J. S., Gómez A. L., Kraemer W. J. Fasting lipoprotein and postprandial triacylglycerol responses to a low-carbohydrate diet supplemented with n-3 fatty acids. Journal of the American College of Nutrition. 2000;19(3):383–391. DOI: 10.1080/07315724.2000.10718935.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Larosa J. C., Fry A. G., Muesing R., Rosing D. R. Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight. Journal of the American Dietetic Association. 1980;77(3):264–270.</mixed-citation><mixed-citation xml:lang="en">Larosa J. C., Fry A. G., Muesing R., Rosing D. R. Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight. Journal of the American Dietetic Association. 1980;77(3):264–270.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Saslow L. R., Mason A. E., Kim S., Goldman V., Ploutz-Snyder R., Bayandorian H., Daubenmier J., Hecht F. M., Moskowitz J. T. An online intervention comparing a very low-carbohydrate ketogenic diet and lifestyle recommendations versus a plate method diet in overweight individuals with type 2 diabetes: a randomized controlled trial. Journal of Medical Internet Research. 2017;19(2):e36. DOI: 10.2196/jmir.5806.</mixed-citation><mixed-citation xml:lang="en">Saslow L. R., Mason A. E., Kim S., Goldman V., Ploutz-Snyder R., Bayandorian H., Daubenmier J., Hecht F. M., Moskowitz J. T. An online intervention comparing a very low-carbohydrate ketogenic diet and lifestyle recommendations versus a plate method diet in overweight individuals with type 2 diabetes: a randomized controlled trial. Journal of Medical Internet Research. 2017;19(2):e36. DOI: 10.2196/jmir.5806.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wolver S., Fadel K., Fieger E., Aburish Z., O'Rourke B., Chandler T.-M., Shimotani D., Clingempeel N., Jain S., Jain A., Puri P. Clinical use of a real-world low carbohydrate diet resulting in reduction of insulin dose, hemoglobin A1c, and weight. Frontiers in Nutrition. 2021;8:690855. DOI: 10.3389/fnut.2021.690855.</mixed-citation><mixed-citation xml:lang="en">Wolver S., Fadel K., Fieger E., Aburish Z., O'Rourke B., Chandler T.-M., Shimotani D., Clingempeel N., Jain S., Jain A., Puri P. Clinical use of a real-world low carbohydrate diet resulting in reduction of insulin dose, hemoglobin A1c, and weight. Frontiers in Nutrition. 2021;8:690855. DOI: 10.3389/fnut.2021.690855.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Zaki H. A., Iftikhar H., Bashir K., Gad H., Fahmy A. S., Elmoheen A. A comparative study evaluating the effectiveness between ketogenic and low-carbohydrate diets on glycemic and weight control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Cureus. 2022;14(5):e25528. DOI: 10.7759/cureus.25528.</mixed-citation><mixed-citation xml:lang="en">Zaki H. A., Iftikhar H., Bashir K., Gad H., Fahmy A. S., Elmoheen A. A comparative study evaluating the effectiveness between ketogenic and low-carbohydrate diets on glycemic and weight control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Cureus. 2022;14(5):e25528. DOI: 10.7759/cureus.25528.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Cicero A. F. G., Benelli M., Brancaleoni M., Dainelli G., Merlini D., Negri R. Middle and long-term impact of a very low-carbohydrate ketogenic diet on cardiometabolic factors: a multi-center, cross-sectional, clinical study. High Blood Pressure &amp; Cardiovascular Prevention. 2015;22:389–394. DOI: 10.1007/s40292-015-0096-1.</mixed-citation><mixed-citation xml:lang="en">Cicero A. F. G., Benelli M., Brancaleoni M., Dainelli G., Merlini D., Negri R. Middle and long-term impact of a very low-carbohydrate ketogenic diet on cardiometabolic factors: a multi-center, cross-sectional, clinical study. High Blood Pressure &amp; Cardiovascular Prevention. 2015;22:389–394. DOI: 10.1007/s40292-015-0096-1.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Field R., Pourkazemi F., Rooney K. Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: a pilot randomized clinical trial. Pain Medicine. 2022;23(2):326–338. DOI: 10.1093/pm/pnab278.</mixed-citation><mixed-citation xml:lang="en">Field R., Pourkazemi F., Rooney K. Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: a pilot randomized clinical trial. Pain Medicine. 2022;23(2):326–338. DOI: 10.1093/pm/pnab278.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Durrer C., McKelvey S., Singer J., Batterham A. M., Johnson J. D., Gudmundson K., Wortman J., Little J. P. A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes. Nature Communications. 2021;12:5367. DOI: 10.1038/s41467-021-25667-4.</mixed-citation><mixed-citation xml:lang="en">Durrer C., McKelvey S., Singer J., Batterham A. M., Johnson J. D., Gudmundson K., Wortman J., Little J. P. A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes. Nature Communications. 2021;12:5367. DOI: 10.1038/s41467-021-25667-4.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Jain V., Shivkumar S., Gupta O. Health-related quality of life (Hr-Qol) in patients with type 2 diabetes mellitus. North American Journal of Medical Sciences. 2014;6(2):96–101. DOI: 10.4103/1947-2714.127752.</mixed-citation><mixed-citation xml:lang="en">Jain V., Shivkumar S., Gupta O. Health-related quality of life (Hr-Qol) in patients with type 2 diabetes mellitus. North American Journal of Medical Sciences. 2014;6(2):96–101. DOI: 10.4103/1947-2714.127752.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Dattilo A. M., Kris-Etherton P. M. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. The American Journal of Clinical Nutrition. 1992;56(2):320–328. DOI: 10.1093/ajcn/56.2.320.</mixed-citation><mixed-citation xml:lang="en">Dattilo A. M., Kris-Etherton P. M. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. The American Journal of Clinical Nutrition. 1992;56(2):320–328. DOI: 10.1093/ajcn/56.2.320.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Austin M. A., Hokanson J. E., Edwards K. L. Hypertriglyceridemia as a cardiovascular risk factor. The American Journal of Cardiology. 1998;81(4A):7B–I2B. DOI: 10.1016/s0002-9149(98)00031-9.</mixed-citation><mixed-citation xml:lang="en">Austin M. A., Hokanson J. E., Edwards K. L. Hypertriglyceridemia as a cardiovascular risk factor. The American Journal of Cardiology. 1998;81(4A):7B–I2B. DOI: 10.1016/s0002-9149(98)00031-9.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Taubes G. Nutrition. The soft science of dietary fat. Science. 2001;291(5513):2536–2345. DOI: 10.1126/science.291.5513.2536.</mixed-citation><mixed-citation xml:lang="en">Taubes G. Nutrition. The soft science of dietary fat. Science. 2001;291(5513):2536–2345. DOI: 10.1126/science.291.5513.2536.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Zammit V. A., Waterman I. J., McKay G., Topping D. Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance. The Journal of Nutrition. 2001;131(8):2074–2077. DOI: 10.1093/jn/131.8.2074.</mixed-citation><mixed-citation xml:lang="en">Zammit V. A., Waterman I. J., McKay G., Topping D. Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance. The Journal of Nutrition. 2001;131(8):2074–2077. DOI: 10.1093/jn/131.8.2074.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G. M. Diet and syndrome X. Current Atherosclerosis Reports. 2000;2(6):503–507. DOI: 10.1007/s11883-000-0050-z.</mixed-citation><mixed-citation xml:lang="en">Reaven G. M. Diet and syndrome X. Current Atherosclerosis Reports. 2000;2(6):503–507. DOI: 10.1007/s11883-000-0050-z.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Krauss R. M. Atherogenic lipoprotein phenotype and diet-gene interactions. The Journal of Nutrition. 2001;131(2):340S–343S. DOI: 10.1093/jn/131.2.340S.</mixed-citation><mixed-citation xml:lang="en">Krauss R. M. Atherogenic lipoprotein phenotype and diet-gene interactions. The Journal of Nutrition. 2001;131(2):340S–343S. DOI: 10.1093/jn/131.2.340S.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Yancy W. S. Jr., Olsen M. K., Guyton J. R., Bakst R. P., Westman E. C. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Annals of Internal Medicine. 2004;140(10):769–777. DOI: 10.7326/0003-4819-140-10-200405180-00006.</mixed-citation><mixed-citation xml:lang="en">Yancy W. S. Jr., Olsen M. K., Guyton J. R., Bakst R. P., Westman E. C. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Annals of Internal Medicine. 2004;140(10):769–777. DOI: 10.7326/0003-4819-140-10-200405180-00006.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Brouns F. Overweight and diabetes prevention: is a low-carbohydrate-high-fat diet recommendable? European Journal of Nutrition. 2018;57:1301–1312. DOI: 10.1007/s00394-018-1636-y.</mixed-citation><mixed-citation xml:lang="en">Brouns F. Overweight and diabetes prevention: is a low-carbohydrate-high-fat diet recommendable? European Journal of Nutrition. 2018;57:1301–1312. DOI: 10.1007/s00394-018-1636-y.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Wong K., Raffray M., Roy-Fleming A., Blunden S., Brazeau A.-S. Ketogenic diet as a normal way of eating in adults with type 1 and type 2 diabetes: a qualitative study. Canadian Journal of Diabetes. 2021;45(2):137–143.E131. DOI: 10.1016/j.jcjd.2020.06.016.</mixed-citation><mixed-citation xml:lang="en">Wong K., Raffray M., Roy-Fleming A., Blunden S., Brazeau A.-S. Ketogenic diet as a normal way of eating in adults with type 1 and type 2 diabetes: a qualitative study. Canadian Journal of Diabetes. 2021;45(2):137–143.E131. DOI: 10.1016/j.jcjd.2020.06.016.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S. H., Lee J.-Y., Kim G. H., Jung K. J., Lee S., Kim H. C., Jee S. H. Two-sample mendelian randomization study of lipid levels and ischemic heart disease. Korean Circulation Journal. 2020;50(10):940–948. DOI: 10.4070/kcj.2020.0131.</mixed-citation><mixed-citation xml:lang="en">Lee S. H., Lee J.-Y., Kim G. H., Jung K. J., Lee S., Kim H. C., Jee S. H. Two-sample mendelian randomization study of lipid levels and ischemic heart disease. Korean Circulation Journal. 2020;50(10):940–948. DOI: 10.4070/kcj.2020.0131.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Mazidi M., Katsiki N., Mikhailidis D. P., Sattar N., Banach M. Lower carbohydrate diets and all-cause and cause-specific mortality: a population-based cohort study and pooling of prospective studies. European Heart Journal. 2019;40(34):2870–2879. DOI: 10.1093/eurheartj/ehz174.</mixed-citation><mixed-citation xml:lang="en">Mazidi M., Katsiki N., Mikhailidis D. P., Sattar N., Banach M. Lower carbohydrate diets and all-cause and cause-specific mortality: a population-based cohort study and pooling of prospective studies. European Heart Journal. 2019;40(34):2870–2879. DOI: 10.1093/eurheartj/ehz174.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Murdoch C., Unwin D., Cavan D., Cucuzzella M., Patel M. Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide. British Journal of General Practice. 2019;69(684):360–361. DOI: 10.3399/bjgp19X704525.</mixed-citation><mixed-citation xml:lang="en">Murdoch C., Unwin D., Cavan D., Cucuzzella M., Patel M. Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide. British Journal of General Practice. 2019;69(684):360–361. DOI: 10.3399/bjgp19X704525.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
