pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2025-14-1-1852pharmjournal-2035Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSПротивоопухолевая активность синтетических производных нафтохинона (обзор)Antitumor activity of synthetic naphthoquinone derivatives (review)https://orcid.org/0000-0001-6132-9617ГоловинаЕ. Л.GolovinaE. L.

634050, г. Томск, Московский тракт, д. 2

2, Moskovsky trakt, Tomsk, 634050

golovina.el@ssmu.ruhttps://orcid.org/0000-0001-7078-4988СеребряковаВ. А.SerebryakovaV. A.

634050, г. Томск, Московский тракт, д. 2

2, Moskovsky trakt, Tomsk, 634050

https://orcid.org/0000-0003-4083-976XВаизоваО. Е.VaizovaO. E.

634050, г. Томск, Московский тракт, д. 2

2, Moskovsky trakt, Tomsk, 634050

Федеральное государственное бюджетное образовательное учреждение высшего образования «Сибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СибГМУ Минздрава России)Siberian State Medical University, SSMU202514022025141103111Copyright © Головина Е.Л., Серебрякова В.А., Ваизова О.Е., 20252025Головина Е.Л., Серебрякова В.А., Ваизова О.Е.Golovina E.L., Serebryakova V.A., Vaizova O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/2035Введение

Введение. Рак является основной причиной смертности во всем мире. Нафтохиноны – группа природных органических соединений с широким спектром активности, включающим кардио-, гепато-, нейропротективное действие, а также противомикробную, противовоспалительную и противоопухолевую активность. 1,4-нафтохинон легко поддается окислению, восстановлению, присоединяет нуклеофилы. Простые и хорошо разработанные методы химической модификации нафтохинонов делают их привлекательными для разработки новых соединений. Известно о противоопухолевом действии природных соединений нафтохинона – плюмбагина, шиконина, лапахола. Такие противоопухолевые антибиотики, как доксорубицин, даунорубицин, имеют в своей структуре 1,4-нафтохиноновый фрагмент.

Текст

Текст. Настоящий обзор посвящен анализу информации о механизмах противоопухолевого действия синтетических производных 1,4-нафтохинона. Обсуждаются возможные мишени их противоопухолевого действия.

Заключение

Заключение. Анализ литературных данных показал, что синтетические соединения на основе молекулы 1,4-нафтохинона обладают противоопухолевым потенциалом. Механизм их противоопухолевого действия может быть связан с индукцией апоптоза через сигнальный путь митогенактивируемой протеинкиназы (МАРК) и путь сигнального преобразователя и активатора транскрипции 3 (STAT3), с ингибированием фосфатазы клеточного цикла (Cdc25), накоплением активных форм кислорода (АФК), угнетением ангиогенеза. Данные, полученные исследователями разных стран, подтверждают перспективность поиска новых соединений с противоопухолевой активностью среди синтетических производных 1,4-нафтохинона для разработки на их основе новых лекарственных средств.

Introduction

Introduction. Cancer is the leading cause of death worldwide. Naphthoquinones are a group of natural organic compounds with a wide range of activity, including cardio-, hepato-, neuroprotective effects, as well as antimicrobial, anti-inflammatory and antitumor activity. 1,4-naphthoquinone is easily oxidized, reduced, and may be easily attached with nucleophiles. Well-developed methods of chemical modification of naphthoquinones make them attractive for the development of new types substances. It is known about the antitumor effect of natural naphthoquinone compounds – plumbagin, shikonin, lapachol. Antitumor antibiotics such as doxorubicin and daunorubicin have a 1,4-naphthoquinone fragment in their structure.

Text

Text. This review is devoted to the analysis of information on the mechanisms of antitumor action of synthetic derivatives of 1,4-naphthoquinone. Possible targets of their antitumor action are discussed.

Conclusion

Conclusion. An analysis of the literature data showed that synthetic compounds based on the 1,4-naphthoquinone molecule have antitumor activity. The mechanism of antitumor action may be associated with the induction of apoptosis through the signaling pathway of mitogen-activated protein kinase (MAPK) and the pathway of the signal transducer and activator of transcription 3 (STAT3), inhibition of cell division cycle phosphatase (Cdc25), accumulation of reactive oxygen species (ROS), inhibition of angiogenesis. The data obtained by researchers from different countries confirm the prospects of searching for new compounds with antitumor activity among synthetic derivatives of 1,4-naphthoquinone for the development of new medicines based on them.

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The authors declare that there are no conflicts of interest present.