Введение

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

10.33380/2305-2066-2025-14-1-1920

pharmjournal-2047

Research Article

ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ

PHARMACEUTICAL TECHNOLOGY

Цеолиты и цеолитоподобные имидазольные каркасы в фармации (обзор)

Zeolites and zeolite imidazole frameworks in pharmacy (review)

https://orcid.org/0000-0001-8695-0346

Бахрушина

Е. О.

Bakhrushina

E. O.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

bachrauschenh@mail.ru

https://orcid.org/0009-0002-8522-2456

Белявский

Н. О.

Belyavsky

N. O.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

https://orcid.org/0000-0003-0236-8389

Кузина

В. Н.

Kuzina

V. N.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

https://orcid.org/0000-0001-8326-3292

Ходенок

А. И.

Khodenok

A. I.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

https://orcid.org/0000-0003-4307-8791

Демина

Н. Б.

Demina

N. B.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

https://orcid.org/0000-0001-8779-3573

Раменская

Г. В.

Ramenskaya

G. V.

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

8/2, Trubetskaya str., Mosсow, 119991

Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И. М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation

2025

07032025

141193221

2025

Бахрушина Е.О., Белявский Н.О., Кузина В.Н., Ходенок А.И., Демина Н.Б., Раменская Г.В.

Bakhrushina E.O., Belyavsky N.O., Kuzina V.N., Khodenok A.I., Demina N.B., Ramenskaya G.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/2047

Введение

Введение. Одним из примеров новых полимеров для систем направленной доставки являются цеолиты (ZEO) и цеолитоподобные имидазольные каркасы (ZIF). ZEO, обладающие высокой пористостью, адсорбционной способностью и физико-химической стабильностью, активно используются в промышленности, экологии, фармации и биомедицине. ZIF, как тип металлоорганического каркаса, отличаются высокой термической и химической устойчивостью, биосовместимостью и регулируемой пористостью, что делает их перспективными для доставки лекарств. Оба полимера благодаря своим свойствам открывают новые возможности для создания таргетных препаратов с пролонгированным действием и минимальными побочными эффектами. Цель данного обзора – охарактеризовать ZEO и ZIF как перспективные полимеры для систем направленной доставки и рассмотреть их основные свойства.

Текст

Текст. В статье рассмотрены строение и методы анализа цеолитов и цеолитоподобных имидазольных каркасов, способы их синтеза, механизм действия, области применения полимеров в качестве систем направленной доставки.

Заключение

Заключение. В обзоре показано, что химические и физические свойства полимеров ZEO и ZIF позволяют разрабатывать эффективные системы направленной доставки лекарственных средств, применяемых в онкологии, офтальмологии, стоматологии и ортопедии. Низкая цитотоксичность, регулируемая загрузка пор полимеров и эффективность внутриклеточного таргетирования подтверждают перспективность использования ZEO и ZIF в медицине.

Introduction

Introduction. One example of new polymers for target delivery systems are zeolites (ZEO) and zeolite imidazole frameworks (ZIF). ZEO are actively used in industry, ecology, pharmacy and biomedicine, having high porosity, adsorption capacity and physico-chemical stability. ZIF, as a type of metal-organic framework, are characterized by high thermal and chemical resistance, biocompatibility and adjustable porosity, which makes them promising for drug delivery. Both polymers, due to their properties, open up new opportunities for the creation of targeted drugs with prolonged action and minimal side effects. The purpose of this review is to characterize ZEO and ZIF as promising polymers for targeted delivery systems and to consider their basic properties.

Text

Text. The article discusses the structure and methods of analysis of zeolites and zeolite imidazole frameworks, methods of their synthesis, mechanism of action, and applications of polymers as directed delivery systems.

Conclusion

Conclusion. The review shows that the chemical and physical properties of ZEO and ZIF polymers make it possible to develop effective targeted drug delivery systems used in oncology, ophthalmology, dentistry and orthopedics. Low cytotoxicity, regulated polymer pore loading and the effectiveness of intracellular targeting confirm the prospects of using ZEO and ZIF in medicine.

цеолитыцеолитоподобные имидазольные каркасыметаллоорганические каркасысинтез цеолитовсистемы доставкиполимеры

zeoliteszeolite imidazole frameworksmetal-organic frameworkssynthesis of zeolitedelivery systemspolymers

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The authors declare that there are no conflicts of interest present.