pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2025-14-3-2140pharmjournal-2169Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSПроизводные 2-амино-4-(2-фурил)пиридин-3-карбонитрилов как перспективные антистафилококковые препаратыDerivatives of 2-amino-4-(furan-2-yl)pyridine-3-carbonitriles as promising antistaphylococcal drugshttps://orcid.org/0009-0008-3495-8491БеспаловД. С.BespalovD. S.

190013, г. Санкт-Петербург, Московский проспект, д. 24–26/49, литера А

24–26/49A, Moskovsky prospect, Saint-Petersburg, 190013

https://orcid.org/0000-0003-3744-9306ЕгоровД. М.EgorovD. M.

199178, г. Санкт-Петербург, 14-я линия В.О., д. 39; 190013, г. Санкт-Петербург, Московский проспект, д. 24–26/49, литера А

39, 14th line V.O., Saint-Petersburg, 199178; 24–26/49A, Moskovsky prospect, Saint-Petersburg, 190013

https://orcid.org/0000-0003-1773-7802КрыловА. С.KrylovA. S.

199178, г. Санкт-Петербург, 14-я линия В.О., д. 39; 190013, г. Санкт-Петербург, Московский проспект, д. 24–26/49, литера А

39, 14th line V.O., Saint-Petersburg, 199178; 24–26/49A, Moskovsky prospect, Saint-Petersburg, 190013

alexandr_krylov@bk.ruhttps://orcid.org/0000-0002-2135-4540ЧерноваЕ. Н.ChernovaE. N.

199178, г. Санкт-Петербург, 14-я линия В.О., д. 39

39, 14th line V.O., Saint-Petersburg, 199178

https://orcid.org/0000-0001-6199-3104КузиковаИ. Л.KuzikovaI. L.

199178, г. Санкт-Петербург, 14-я линия В.О., д. 39

39, 14th line V.O., Saint-Petersburg, 199178

https://orcid.org/0000-0002-5620-1317ЖаковскаяЗ. А.ZhakovskayaZ. A.

199178, г. Санкт-Петербург, 14-я линия В.О., д. 39

39, 14th line V.O., Saint-Petersburg, 199178

Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный технологический институт (технический университет)» (СПбГТИ(ТУ))Saint Petersburg State Institute of Technology (Technical University)Федеральное государственное бюджетное учреждение науки «Санкт-Петербургский Федеральный исследовательский центр Российской академии наук» (СПб ФИЦ РАН); Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный технологический институт (технический университет)» (СПбГТИ(ТУ))St. Petersburg Federal Research Center of the Russian Academy of Sciences; Saint Petersburg State Institute of Technology (Technical University)Федеральное государственное бюджетное учреждение науки «Санкт-Петербургский Федеральный исследовательский центр Российской академии наук» (СПб ФИЦ РАН)St. Petersburg Federal Research Center of the Russian Academy of Sciences2025020920251438290Copyright © Беспалов Д.С., Егоров Д.М., Крылов А.С., Чернова Е.Н., Кузикова И.Л., Жаковская З.А., 20252025Беспалов Д.С., Егоров Д.М., Крылов А.С., Чернова Е.Н., Кузикова И.Л., Жаковская З.А.Bespalov D.S., Egorov D.M., Krylov A.S., Chernova E.N., Kuzikova I.L., Zhakovskaya Z.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/2169Введение

Введение. Соединения, содержащие в своем составе фурановый фрагмент, часто проявляют антимикробную активность. Несмотря на то что среди производных пиридина нет препаратов, проявляющих противомикробную активность, его комбинация с фурановым заместителем может рассматриваться как перспективный тандем для создания эффективных антимикробных препаратов.

Цель

Цель. Целью данного исследования является синтез гибридных структур, содержащих фурановый и аминопиридиновый фрагменты и исследование их антимикробных свойств.

Материалы и методы

Материалы и методы. Реакцией фурфурола, малонодинитрила, ацетата аммония и соответствующего кетона получена серия 5,6-замещенных 2-амино-4-(2-фурил)-пиридин-3-карбонитрилов.

Результаты и обсуждение

Результаты и обсуждение. Для полученных соединений исследована их антимикробная активность в отношении бактерий Staphylococcus aureus, Pseudomonas aeruginosa и дрожжеподобных грибов Candida utilis. Определены соединения, обладающие высокой антибактериальной активностью, проведена оценка влияния заместителей в 5 и 6 положениях на исследуемую активность.

Заключение

Заключение. Получен ряд новых замещенных 5,6-диалкил-4-фурил-2-аминопиридинил-3-карбонитрилов и исследована in vitro их антимикробная активность.

Introduction

Introduction. Furan-containing compounds frequently demonstrate antimicrobial properties. While pyridine-based compounds alone lack antimicrobial activity, their structural combination with a furan moiety presents a promising approach for designing novel antimicrobial agents.

Aim

Aim. This study aims to synthesize hybrid molecules incorporating both furan and aminopyridine fragments and evaluate their antimicrobial potential.

Materials and methods

Materials and methods. We prepared a series of 5,6-substituted 2-amino-4-(2-furyl)pyridine-3-carbonitriles via a one-pot multicomponent reaction using furfural, malononitrile, ammonium acetate, and selected ketones.

Results and Discussion

Results and Discussion. The synthesized compounds exhibited significant antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and the yeast-like fungus Candida utilis. Structure-activity relationship analysis revealed that substituents at the 5- and 6-positions critically influence antibacterial potency.

Conclusion

Conclusion. We successfully developed a novel series of 2-amino-5,6-dialkyl-4-(furan-2-yl)pyridine-3-carbonitriles and characterized their in vitro antimicrobial effects, identifying key structural features for enhanced activity.

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The authors declare that there are no conflicts of interest present.