pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2026-15-2-2085pharmjournal-2331Research ArticleФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯPHARMACEUTICAL TECHNOLOGYТермочувствительные полимеры в системах доставки лекарств (обзор)Thermosensitive polymers in drug delivery systems (review)https://orcid.org/0000-0003-0486-2444МасловД. О.MaslovD. O.

119571, г. Москва, пр-т Вернадского, д. 86

86, prospekt Vernadskogo, Moscow, 119571

maslovv1921@mail.ruhttps://orcid.org/0000-0002-1597-6992ЗолотареваМ. С.ZolotarevaM. S.

119571, г. Москва, пр-т Вернадского, д. 86

86, prospekt Vernadskogo, Moscow, 119571

Федеральное государственное бюджетное образовательное учреждение высшего образования «МИРЭА – Российский технологический университет» (РТУ МИРЭА)MIREA – Russian Technological University2026110620261527280Copyright © Маслов Д.О., Золотарева М.С., 20262026Маслов Д.О., Золотарева М.С.Maslov D.O., Zolotareva M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/2331Введение

Введение. Водорастворимые полимеры, чувствительные к температуре, перспективны для использования в фармацевтической разработке для создания «умных» систем доставки лекарств.

Текст

Текст. В данной обзорной статье рассматриваются три группы термочувствительных полимеров: с нижней критической температурой растворения (LCST) и с верхней критической температурой растворения (UCST), а также полимеры, проявляющие оба типа поведения. В статье приведена их классификация, особенности разработки, примеры применения и модификаций для придания необходимых свойств.

Заключение

Заключение. Полимеры с LCST- и UCST-поведением являются перспективными материалами для разработки термочувствительных систем доставки лекарственных средств, которые уже используются в биомедицине.

Introduction

Introduction. Water-soluble polymers that are sensitive to temperature are promising for use in pharmaceutical development to create "smart" drug delivery systems.

Text

Text. This review article discusses three groups of thermosensitive polymers: those with a lower critical solution temperature (LCST) and those with an upper critical solution temperature (UCST), as well as polymers exhibiting both types of behavior. The article presents their classification, development features, application examples and modifications to give the necessary properties.

Conclusion

Conclusion. Polymers with LCST and UCST behavior are promising materials for the development of thermosensitive drug delivery systems that are already used in biomedicine.

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The authors declare that there are no conflicts of interest present.