References

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

pharmjournal-289

Research Article

ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИИ

PHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGY

ВЛИЯНИЕ ГИДРОКСИЭТИЛЦЕЛЛЮЛОЗЫ НА ВЫСВОБОЖДЕНИЕ ГЛИБЕНКЛАМИДА ИЗ ТАБЛЕТОК ПРОЛОНГИРОВАННОГО ДЕЙСТВИЯ

EFFECT OF HYDROXYETHYLCELLULOSE ON THE RELEASE OF GLIBENCLAMIDE FROM SUSTAINED RELEASE TABLETS

Трофимов

С. В.

Trofimov

S. V.

noemail@neicon.ru

Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииPyatigorsk Medico-Pharmaeutical Institute, departament of State Federal - Funded Educational Institution of Higher Vocational Training Volgograd State Medical University of the Ministry of Health of the Russian Federation

2016

09012019

035258

2019

Трофимов С.В.

Trofimov S.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/289

Приведены практические результаты исследования влияния размера частиц и способа обработки активной субстанции глибенкламида на профиль высвобождения из матричной таблетированной формы пролонгированного действия. Изучено влияние гидроксиэтилцеллюлозы как компонента, используемого для пролонгации высвобождения, а так же как вещества, способного улучшать скорость рас творения и способствовать более полному высвобождению активной субстанции из пролонгированной готовой лекарственной формы.

With this study the results of influence particle size distribution and method of modification API on dissolution profile from matrix tablets with sustained release are shown. The effect of Hydroxyethylcellulose, which is used as sustained release agent, also as an excipient, able to improve dissolution speed and maintain more complete release of an API from sustained release formulation, with glibenclamide as an example has been studied.

гидроксиэтилцеллюлозаглибенкламидрастворениепролонгированное высвобождение

Hydroxyethylcelluloseglibenclamidedissolutionsustained release

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The authors declare that there are no conflicts of interest present.