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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pharmjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Разработка и регистрация лекарственных средств</journal-title><trans-title-group xml:lang="en"><trans-title>Drug development &amp; registration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-2066</issn><issn pub-type="epub">2658-5049</issn><publisher><publisher-name>LLC «CPHA»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pharmjournal-291</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGY</subject></subj-group></article-categories><title-group><article-title>ЦИКЛОДЕКСТРИНЫ И ИХ ПРИМЕНЕНИЕ В ФАРМАЦЕВТИЧЕСКОЙ ПРОМЫШЛЕННОСТИ (ОБЗОР)</article-title><trans-title-group xml:lang="en"><trans-title>CYCLODEXTRINS AND THEIR APPLICATION IN PHARMACEUTICAL INDUSTRY (REVIEW)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кедик</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kedik</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Panov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюкова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyukova</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотарева</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotareva</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский технологический университет (МИТХТ)</institution></aff><aff xml:lang="en"><institution>Moscow Technological University (MITHT)</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2019</year></pub-date><volume>0</volume><issue>3</issue><fpage>68</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кедик С.А., Панов А.В., Тюкова В.С., Золотарева М.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кедик С.А., Панов А.В., Тюкова В.С., Золотарева М.С.</copyright-holder><copyright-holder xml:lang="en">Kedik S.A., Panov A.V., Tyukova V.S., Zolotareva M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmjournal.ru/jour/article/view/291">https://www.pharmjournal.ru/jour/article/view/291</self-uri><abstract><p>В обзоре литературы рассмотрены основные свойства циклодекстринов и возможность их использования в рецептурах раз личных лекарственных форм в качестве вспомогательных веществ, благодаря которым становится возможным увеличение растворимости лекарственных веществ, биодоступности и стабильности лекарственного препарата.</p></abstract><trans-abstract xml:lang="en"><p>In the review describes the main properties of cyclodextrins and their potential use in the formulations in various dosage forms as excipients, by which it becomes possible to modify the solubility of drugs, increase the bioavailability and stability of the drug.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цик лодекстрины</kwd><kwd>комплекс вк лючения</kwd><kwd>растворимость</kwd><kwd>биодост упность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cyclodextrins</kwd><kwd>inclusion complex</kwd><kwd>solubility</kwd><kwd>bioavailability</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">А.В. Душкин, Л.П. Сунцова, С.С. Халиков. Механохимическая технология растворимости лекарственных веществ // Pharmaceutical sciences. 2013. № 1. С. 448-457.</mixed-citation><mixed-citation xml:lang="en">А.В. Душкин, Л.П. Сунцова, С.С. Халиков. Механохимическая технология растворимости лекарственных веществ // Pharmaceutical sciences. 2013. № 1. С. 448-457.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">T. Loftsson, D. Duchene, Cyclodextrins and their applications // International Journal of Pharmaceutics. 2007. № 329. P. 1-11.</mixed-citation><mixed-citation xml:lang="en">T. Loftsson, D. Duchene, Cyclodextrins and their applications // International Journal of Pharmaceutics. 2007. № 329. P. 1-11.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">H. Dodziuk. Cyclodextrins and their complexes. - Wheinheim: Wiley-VCH Verlag, 2006. 489 p.</mixed-citation><mixed-citation xml:lang="en">H. Dodziuk. Cyclodextrins and their complexes. - Wheinheim: Wiley-VCH Verlag, 2006. 489 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Н.Г. Гулюк, Т.С. Пучкова, Д.М. Пихало, В.А. Гулакова. Исследование кинетики кислотного и ферментативного гидролиза циклодекстринов // Пищевая и перерабатывающая промышленность. 2010. № 12. С. 67.</mixed-citation><mixed-citation xml:lang="en">Н.Г. Гулюк, Т.С. Пучкова, Д.М. Пихало, В.А. Гулакова. Исследование кинетики кислотного и ферментативного гидролиза циклодекстринов // Пищевая и перерабатывающая промышленность. 2010. № 12. С. 67.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">E.M. Martin Del Valle. Cyclodextrins and their uses: a review // Process Biochemistry. 2004. № 39. P. 1033-1046.</mixed-citation><mixed-citation xml:lang="en">E.M. Martin Del Valle. Cyclodextrins and their uses: a review // Process Biochemistry. 2004. № 39. P. 1033-1046.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">О.А. Иноземцева. Физико-химические свойства монослоев и пленок Ленгмюра - Блоджетт силилированных бромсодержащих производных β-циклодекстрина: дис. … к. хим. н. - Саратов: СГУ, 2006. 151 с.</mixed-citation><mixed-citation xml:lang="en">О.А. Иноземцева. Физико-химические свойства монослоев и пленок Ленгмюра - Блоджетт силилированных бромсодержащих производных β-циклодекстрина: дис. … к. хим. н. - Саратов: СГУ, 2006. 151 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">G. Castronuovo, M. Niccoli, Thermodynamics of inclusion complexes of natural and modified cyclodextrins with acetylsalicylic acid and ibuprofen in aqueous solution at 298 K // Thermochimica Acta. 2013. № 557. P. 44-49.</mixed-citation><mixed-citation xml:lang="en">G. Castronuovo, M. Niccoli, Thermodynamics of inclusion complexes of natural and modified cyclodextrins with acetylsalicylic acid and ibuprofen in aqueous solution at 298 K // Thermochimica Acta. 2013. № 557. P. 44-49.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">C. Krzysztof, K. Centkowska. Use of cyclodextrins in topical formulations: Practical aspects // European Journal of Pharmaceutical and Biopharmaceutics. 2008. № 68. P. 467-478.</mixed-citation><mixed-citation xml:lang="en">C. Krzysztof, K. Centkowska. Use of cyclodextrins in topical formulations: Practical aspects // European Journal of Pharmaceutical and Biopharmaceutics. 2008. № 68. P. 467-478.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">K. Hussein, M. Turk, M.A. Wahl. Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods // Pharmaceutical Research. 2007. V. 24. № 3. P. 585-592.</mixed-citation><mixed-citation xml:lang="en">K. Hussein, M. Turk, M.A. Wahl. Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods // Pharmaceutical Research. 2007. V. 24. № 3. P. 585-592.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">A. Bounaceur, E. Rodier. Study of the maturation of a Ketoprofen/β-cyclodextrin complex // Journal of Pharmaceutical Science and Technology. 2010. V. 2(3). P.171-183.</mixed-citation><mixed-citation xml:lang="en">A. Bounaceur, E. Rodier. Study of the maturation of a Ketoprofen/β-cyclodextrin complex // Journal of Pharmaceutical Science and Technology. 2010. V. 2(3). P.171-183.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">S.R.S. Rudrangi, W. Kaialy, M.U. Ghori, V. Trivedi, M.J. Snowden, B.D. Alexander. Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process // European Journal of Pharmaceutics and Biopharmaceutics. 2016. V. 104. P. 164-170. URL: http://dx.doi.org/10.1016/j.ejpb.2016.04.024 (дата обращения 15.07.2016).</mixed-citation><mixed-citation xml:lang="en">S.R.S. Rudrangi, W. Kaialy, M.U. Ghori, V. Trivedi, M.J. Snowden, B.D. Alexander. Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process // European Journal of Pharmaceutics and Biopharmaceutics. 2016. V. 104. P. 164-170. URL: http://dx.doi.org/10.1016/j.ejpb.2016.04.024 (дата обращения 15.07.2016).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Патент US 4228160 A. Inclusion complex of cyclodextrin and Indomethacin and a process for the preparation thereof, method of use and pharmaceutical composition / L.J. Penkler, M.D. Bodley. - № 95/001152; filing 22.05.95; publ. 07.12.95.</mixed-citation><mixed-citation xml:lang="en">Патент US 4228160 A. Inclusion complex of cyclodextrin and Indomethacin and a process for the preparation thereof, method of use and pharmaceutical composition / L.J. Penkler, M.D. Bodley. - № 95/001152; filing 22.05.95; publ. 07.12.95.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Патент US № 5472954 A. Cyclodextrin complexation / T. Loftsson. - № 07/912853; filing 07.14.1992; publ. 06.28.1994.</mixed-citation><mixed-citation xml:lang="en">Патент US № 5472954 A. Cyclodextrin complexation / T. Loftsson. - № 07/912853; filing 07.14.1992; publ. 06.28.1994.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">H. Yano, F. Hirayama, M. Kamada, H. Arima, K. Uekama. Colon-specific delivery of prednisolone-appended a-cyclodextrin conjugate: alleviation of systemic side effect after oral administration // J. Cont. Rel. 2002. V. 79. № 1-3. P. 103-112.</mixed-citation><mixed-citation xml:lang="en">H. Yano, F. Hirayama, M. Kamada, H. Arima, K. Uekama. Colon-specific delivery of prednisolone-appended a-cyclodextrin conjugate: alleviation of systemic side effect after oral administration // J. Cont. Rel. 2002. V. 79. № 1-3. P. 103-112.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Патент US № 6699849. Cyclodextrin complexes of benzodiazepines / T. Loftsson, M. Masson, E. Stefansson. - № 09/250185; filing 02.16.1999; publ. 03.02.2004.</mixed-citation><mixed-citation xml:lang="en">Патент US № 6699849. Cyclodextrin complexes of benzodiazepines / T. Loftsson, M. Masson, E. Stefansson. - № 09/250185; filing 02.16.1999; publ. 03.02.2004.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">I. Kacso, G. Borodi, S. I. Farcas, I. Bratu. Inclusion compound of vitamin B13 in b-Cyclodextrin // J. Phys.: Conference Series. 2009. V. 182. P. 1-5.</mixed-citation><mixed-citation xml:lang="en">I. Kacso, G. Borodi, S. I. Farcas, I. Bratu. Inclusion compound of vitamin B13 in b-Cyclodextrin // J. Phys.: Conference Series. 2009. V. 182. P. 1-5.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">K. Uekama, T. Fujinaga, F. Hirayama. Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation // Pharmaceutical Science. 1983. № 72. P. 1338-1341.</mixed-citation><mixed-citation xml:lang="en">K. Uekama, T. Fujinaga, F. Hirayama. Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation // Pharmaceutical Science. 1983. № 72. P. 1338-1341.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Y. Nakai, K. Yamamoto, K. Terada. Interaction of tri-O-methyl-β-cyclodextrin with drugs // J. Incl. Phenom. 1984. № 2. P. 523-531.</mixed-citation><mixed-citation xml:lang="en">Y. Nakai, K. Yamamoto, K. Terada. Interaction of tri-O-methyl-β-cyclodextrin with drugs // J. Incl. Phenom. 1984. № 2. P. 523-531.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">J.J. Berzas Nevado, J.A. Murillo Pulgarin, M.A. Gomez Laguna. Spectrofluorometric study of the β-cyclodextrin: vitamin K3 complex and determination of vitamin K3 // Talanta. 2001. № 53. P. 951-959.</mixed-citation><mixed-citation xml:lang="en">J.J. Berzas Nevado, J.A. Murillo Pulgarin, M.A. Gomez Laguna. Spectrofluorometric study of the β-cyclodextrin: vitamin K3 complex and determination of vitamin K3 // Talanta. 2001. № 53. P. 951-959.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">L.A. Belyakova, A.M. Varvarin, D.Yu. Lyashenko, O.V. Khora, E.I. Oranskaya. Complexation in a β-cyclodextrin-salicylic acid system // Colloid Journal. 2007. V. 69. № 5. P. 546-551.</mixed-citation><mixed-citation xml:lang="en">L.A. Belyakova, A.M. Varvarin, D.Yu. Lyashenko, O.V. Khora, E.I. Oranskaya. Complexation in a β-cyclodextrin-salicylic acid system // Colloid Journal. 2007. V. 69. № 5. P. 546-551.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">K. Uekama, M. Otagiri, K Tasaki, A. Sugii. Improvement of oral bioavailability of Prednizalone by β-cyclodextrin complexation in humans // J. Pharm. Dyn. 1993. № 6. P. 124-127.</mixed-citation><mixed-citation xml:lang="en">K. Uekama, M. Otagiri, K Tasaki, A. Sugii. Improvement of oral bioavailability of Prednizalone by β-cyclodextrin complexation in humans // J. Pharm. Dyn. 1993. № 6. P. 124-127.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">T. Vila-Jato, J. Blanco. Spirolactone/β-cyclodextrine complex: oral bioavailability in humans // Acta Pharmaceutical Technology. 1998. № 32. P. 82-85.</mixed-citation><mixed-citation xml:lang="en">T. Vila-Jato, J. Blanco. Spirolactone/β-cyclodextrine complex: oral bioavailability in humans // Acta Pharmaceutical Technology. 1998. № 32. P. 82-85.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">K. Uekama, K. Udo, T. Irie. Improvement of dissolution and absorption characteristics of indomethacin by water soluble α-cyclodextrine-epichlorohydrin polymer // Acta Pharm. Suec. 1987. № 24. P. 27-36.</mixed-citation><mixed-citation xml:lang="en">K. Uekama, K. Udo, T. Irie. Improvement of dissolution and absorption characteristics of indomethacin by water soluble α-cyclodextrine-epichlorohydrin polymer // Acta Pharm. Suec. 1987. № 24. P. 27-36.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">J. Pitha, S.M. Harmau, M.E. Michel. Hydrophilic cyclodextrin derivates enable effective oral administration of steroidal hormones // J. Pharm. Sci. 1996. № 75. P. 165-167.</mixed-citation><mixed-citation xml:lang="en">J. Pitha, S.M. Harmau, M.E. Michel. Hydrophilic cyclodextrin derivates enable effective oral administration of steroidal hormones // J. Pharm. Sci. 1996. № 75. P. 165-167.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">H. Beraldo, R.D. Sinisterra, L.R. Vieira, M.C. Doretto. An effective anticonvulsant prepared following a host-guest strategy that uses hydroxypropyl-beta-cyclodextrin and benzaldehyde semicarbazone // Biochem Biophys Res Commun. 2002. № 296. P. 241-246.</mixed-citation><mixed-citation xml:lang="en">H. Beraldo, R.D. Sinisterra, L.R. Vieira, M.C. Doretto. An effective anticonvulsant prepared following a host-guest strategy that uses hydroxypropyl-beta-cyclodextrin and benzaldehyde semicarbazone // Biochem Biophys Res Commun. 2002. № 296. P. 241-246.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">K. Nishimura, R. Hidaka, F. Hirayama, H. Arima, K. Uekama. Improvement of dispersion and release properties of nifedipine in suppositories by complexation with 2-hydroxypropyl-β-cyclodextrin // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2006. № 56. P. 85-88.</mixed-citation><mixed-citation xml:lang="en">K. Nishimura, R. Hidaka, F. Hirayama, H. Arima, K. Uekama. Improvement of dispersion and release properties of nifedipine in suppositories by complexation with 2-hydroxypropyl-β-cyclodextrin // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2006. № 56. P. 85-88.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">M. Otagirri, T. Imai. Improvements to some pharmaceutical properties of flurbiprofen by β- and γ-cyclodextrin complexations // Acta Pharm. Suec. 1993. № 20. P. 1-10.</mixed-citation><mixed-citation xml:lang="en">M. Otagirri, T. Imai. Improvements to some pharmaceutical properties of flurbiprofen by β- and γ-cyclodextrin complexations // Acta Pharm. Suec. 1993. № 20. P. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">K. Kikuchi, F. Hirayama. Improvement of oral and rectal bioavailabilities of carmofur by methylated-β- cyclodextrin complexation // International Journal of Pharmaceutics. 1997. № 39. P. 191-198.</mixed-citation><mixed-citation xml:lang="en">K. Kikuchi, F. Hirayama. Improvement of oral and rectal bioavailabilities of carmofur by methylated-β- cyclodextrin complexation // International Journal of Pharmaceutics. 1997. № 39. P. 191-198.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">L. Szente, I. Apostol, J. Szejtli. Suppositories containing cyclodextrin complexes // Pharmazie. 1995. № 40. P. 406-407.</mixed-citation><mixed-citation xml:lang="en">L. Szente, I. Apostol, J. Szejtli. Suppositories containing cyclodextrin complexes // Pharmazie. 1995. № 40. P. 406-407.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">B. Malaekeh-Nikouei, S.A.S. Tabassi, G. Gerayeli, M.A. Salmani, A. Gholamzadeh. The effect of cyclodextrin mixtures on aqueous solubility of beclomethasone dipropionate // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2012. V. 72. I. 3. P. 383-387.</mixed-citation><mixed-citation xml:lang="en">B. Malaekeh-Nikouei, S.A.S. Tabassi, G. Gerayeli, M.A. Salmani, A. Gholamzadeh. The effect of cyclodextrin mixtures on aqueous solubility of beclomethasone dipropionate // Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2012. V. 72. I. 3. P. 383-387.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">R. Challa, A. Ahuja, J. Ali. Cyclodextrins in drug delivery: an update review // Pharmaceutical Science Technology. 2005. V. 6. № 2. P. 329-357.</mixed-citation><mixed-citation xml:lang="en">R. Challa, A. Ahuja, J. Ali. Cyclodextrins in drug delivery: an update review // Pharmaceutical Science Technology. 2005. V. 6. № 2. P. 329-357.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">T. Loftsson, D. Duchêneb. Cyclodextrins and their pharmaceutical applications // International Journal of Pharmaceutics. 2007. V. 329. I. 1-2. P. 1-11.</mixed-citation><mixed-citation xml:lang="en">T. Loftsson, D. Duchêneb. Cyclodextrins and their pharmaceutical applications // International Journal of Pharmaceutics. 2007. V. 329. I. 1-2. P. 1-11.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">А.В. Астахова, Н.Б. Демина. Современные технологии лекарственных форм: получение, исследование и применение комплексов включения лекарственных веществ с циклодекстринами (обзор) // Химико-фармацевтический журнал. 2004. Т. 38. № 2. С. 46-49.</mixed-citation><mixed-citation xml:lang="en">А.В. Астахова, Н.Б. Демина. Современные технологии лекарственных форм: получение, исследование и применение комплексов включения лекарственных веществ с циклодекстринами (обзор) // Химико-фармацевтический журнал. 2004. Т. 38. № 2. С. 46-49.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">S.V. Kurkov, D.E. Madden, D. Carr, T. Loftsson. The Effect of Parenterally Administered Cyclodextrins on the Pharmacokinetics of Coadministered Drugs // Journal of Pharmaceutical Sciences. 2012. V. 101. Issue 12. P. 4367-4668.</mixed-citation><mixed-citation xml:lang="en">S.V. Kurkov, D.E. Madden, D. Carr, T. Loftsson. The Effect of Parenterally Administered Cyclodextrins on the Pharmacokinetics of Coadministered Drugs // Journal of Pharmaceutical Sciences. 2012. V. 101. Issue 12. P. 4367-4668.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">S. Baboota, R. Khanna, S.P. Agarwal. Cyclodextrins in Drug Delivery Systems: An update // Pharmaceutical Information. 2003. № 58. Р. 73-74.</mixed-citation><mixed-citation xml:lang="en">S. Baboota, R. Khanna, S.P. Agarwal. Cyclodextrins in Drug Delivery Systems: An update // Pharmaceutical Information. 2003. № 58. Р. 73-74.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">W. Leng, L. Qin, X. Tang. Chitosan and Randomly Methylated β-cyclodextrin Combined to Enhance the Absorption and Elevate the Bioavailability of Estradiol Intranasally: in situ and in vivo Studies // The Journal of American Science. 2006. V. 2(1). P. 61-66.</mixed-citation><mixed-citation xml:lang="en">W. Leng, L. Qin, X. Tang. Chitosan and Randomly Methylated β-cyclodextrin Combined to Enhance the Absorption and Elevate the Bioavailability of Estradiol Intranasally: in situ and in vivo Studies // The Journal of American Science. 2006. V. 2(1). P. 61-66.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">M.E. Brewster, T. Loftsson. Cyclodextrins as pharmaceutical solubilizers // Advanced Drug Delivery Reviews. 2007. V. 59. I. 7. P. 645-666.</mixed-citation><mixed-citation xml:lang="en">M.E. Brewster, T. Loftsson. Cyclodextrins as pharmaceutical solubilizers // Advanced Drug Delivery Reviews. 2007. V. 59. I. 7. P. 645-666.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">E. Stefánsson, T. Loftsson. Cyclodextrins in eye drop formulations // Journal Incl. Phenom. Macroc. Chem. 2002. № 44. P. 23-27.</mixed-citation><mixed-citation xml:lang="en">E. Stefánsson, T. Loftsson. Cyclodextrins in eye drop formulations // Journal Incl. Phenom. Macroc. Chem. 2002. № 44. P. 23-27.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">T. Loftsson, P. Jarho, M. Másson, T. Järvinen. Cyclodextrins in drug delivery // Expert Opinion on Drug Delivery. 2005. V. 2. I. 2. P. 335-351.</mixed-citation><mixed-citation xml:lang="en">T. Loftsson, P. Jarho, M. Másson, T. Järvinen. Cyclodextrins in drug delivery // Expert Opinion on Drug Delivery. 2005. V. 2. I. 2. P. 335-351.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">T. Loftsson, S.D. Sigfússon, H.H. Sigurðsson, M. Másson. The effects of cyclodextrins on topical delivery of hydrocortisone: the aqueous diffusion layer // STP Pharma Sci. 2003. № 13. P. 125-131.</mixed-citation><mixed-citation xml:lang="en">T. Loftsson, S.D. Sigfússon, H.H. Sigurðsson, M. Másson. The effects of cyclodextrins on topical delivery of hydrocortisone: the aqueous diffusion layer // STP Pharma Sci. 2003. № 13. P. 125-131.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">K. Ravindra Reddy, M. Ravi Shankar Yadav, P. Sabitha Reddy. Preparation and evaluation of Aceclofenac ophthalmic in-situ gels // Journal of Chemical, Biological and Physical Sciences. 2011. V. 1. № 2. P. 289-298.</mixed-citation><mixed-citation xml:lang="en">K. Ravindra Reddy, M. Ravi Shankar Yadav, P. Sabitha Reddy. Preparation and evaluation of Aceclofenac ophthalmic in-situ gels // Journal of Chemical, Biological and Physical Sciences. 2011. V. 1. № 2. P. 289-298.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">E. Stefansson, S. Thorisdottir, O.G. Gudmundsson, T. Loftsson, H. Fridriksdottir, J.K. Kristinsson. HPβCD in eye drops: evaluation of artificial tear-drops in human patients // Proceedings of the 8th International Cyclodextrins Symposium (J. Szejtli and L. Szente, Eds.). - Dordrecht: Kluwer Academic Publishers. 1996. P. 391-394.</mixed-citation><mixed-citation xml:lang="en">E. Stefansson, S. Thorisdottir, O.G. Gudmundsson, T. Loftsson, H. Fridriksdottir, J.K. Kristinsson. HPβCD in eye drops: evaluation of artificial tear-drops in human patients // Proceedings of the 8th International Cyclodextrins Symposium (J. Szejtli and L. Szente, Eds.). - Dordrecht: Kluwer Academic Publishers. 1996. P. 391-394.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">M. Masson, T. Loftsson, H. Fridriksdottir, D.S. Petersen. Complexation of drug compounds with ionic and ionic cyclodextrins // Proceedings of the 8th International Cyclodextrins Symposium (J. Szejtli and L. Szente, Eds.). - Dordrecht: Kluwer Academic Publishers. 1996. P. 365-368.</mixed-citation><mixed-citation xml:lang="en">M. Masson, T. Loftsson, H. Fridriksdottir, D.S. Petersen. Complexation of drug compounds with ionic and ionic cyclodextrins // Proceedings of the 8th International Cyclodextrins Symposium (J. Szejtli and L. Szente, Eds.). - Dordrecht: Kluwer Academic Publishers. 1996. P. 365-368.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">A.R. Bary, I.G. Tucker, N.M. Davies. Considerations in the use of hydroxypropyl-beta-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone // Eur. J. Pharm Biopharm. 2000. V. 50(2). P. 237-244.</mixed-citation><mixed-citation xml:lang="en">A.R. Bary, I.G. Tucker, N.M. Davies. Considerations in the use of hydroxypropyl-beta-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone // Eur. J. Pharm Biopharm. 2000. V. 50(2). P. 237-244.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">T. Loftsson, E. Stefansson. Cyclodextrin enhanced topical delivery of corticosteroids to the eye // Acta Ophthalmol. Scand. 2002. № 80. P. 144-150.</mixed-citation><mixed-citation xml:lang="en">T. Loftsson, E. Stefansson. Cyclodextrin enhanced topical delivery of corticosteroids to the eye // Acta Ophthalmol. Scand. 2002. № 80. P. 144-150.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">E. Gudmundsdottir, E. Stefansson, G. Bjarnadottir, J.F. Sigurjonsdottir, G. Gudmundsdottir, M. Masson, T. Loftsson. Methazolamide 1% in cyclodextrin solution lowers IOP in ocular hypertensive humans // Inv. Ophthalmol. Vis. Sci. 2000. V. 41(11). P. 3552-3554.</mixed-citation><mixed-citation xml:lang="en">E. Gudmundsdottir, E. Stefansson, G. Bjarnadottir, J.F. Sigurjonsdottir, G. Gudmundsdottir, M. Masson, T. Loftsson. Methazolamide 1% in cyclodextrin solution lowers IOP in ocular hypertensive humans // Inv. Ophthalmol. Vis. Sci. 2000. V. 41(11). P. 3552-3554.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">N. Nagai, Y. Ito, N. Okamoto. Preparation of ophthalmic formulations containing cilostazol as an antiglaukoma agent and improvement in its permeability through the rabbit cornea // J. Oleo Science. 2010. V. 59(8). P. 423-430.</mixed-citation><mixed-citation xml:lang="en">N. Nagai, Y. Ito, N. Okamoto. Preparation of ophthalmic formulations containing cilostazol as an antiglaukoma agent and improvement in its permeability through the rabbit cornea // J. Oleo Science. 2010. V. 59(8). P. 423-430.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">A. Bozkir, Z. Denli. Effect of hydroxypropil-β-cyclpdextrin on the solubility, stability and in vitro release of ciprofloxacin for ocular drug delivery // Acta Poloniae Pharmaceutica - Drug research. 2012. V. 69 (4). P. 719-724.</mixed-citation><mixed-citation xml:lang="en">A. Bozkir, Z. Denli. Effect of hydroxypropil-β-cyclpdextrin on the solubility, stability and in vitro release of ciprofloxacin for ocular drug delivery // Acta Poloniae Pharmaceutica - Drug research. 2012. V. 69 (4). P. 719-724.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">T. Jansen, B. Xhonneux, J. Mesens, M. Borgers. Betacyclodextrins as vehicles in eye-drop formulation: an evaluation of their effects on rabbit corneal epiteliumn // Lens Eye Toxicity Res. 1990. № 7. P. 459-468.</mixed-citation><mixed-citation xml:lang="en">T. Jansen, B. Xhonneux, J. Mesens, M. Borgers. Betacyclodextrins as vehicles in eye-drop formulation: an evaluation of their effects on rabbit corneal epiteliumn // Lens Eye Toxicity Res. 1990. № 7. P. 459-468.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">N. Nagai, Y. Ito, N. Takeuchi, Pharmacokinetic and Pharmacodynamic evalution of the anti-cataract effect of drops containing Disulfiram and lowsubstituted methylcellulose using ICR/f rats as a hereditary cataract model // Biol. Pharm. Bull. 2012. V. 35(2). P. 239-245.</mixed-citation><mixed-citation xml:lang="en">N. Nagai, Y. Ito, N. Takeuchi, Pharmacokinetic and Pharmacodynamic evalution of the anti-cataract effect of drops containing Disulfiram and lowsubstituted methylcellulose using ICR/f rats as a hereditary cataract model // Biol. Pharm. Bull. 2012. V. 35(2). P. 239-245.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Патент РФ № 2485939. Офтальмологический препарат в виде глазных капель, содержащий дисульфирам и таурин / С.А. Кедик, Е.И. Ярцев, А.В. Панов, В.В. Суслов, И.В. Сакаева. - № 2012125357/15; заявл. 19.06.2012; опубл. 27.06.2013.</mixed-citation><mixed-citation xml:lang="en">Патент РФ № 2485939. Офтальмологический препарат в виде глазных капель, содержащий дисульфирам и таурин / С.А. Кедик, Е.И. Ярцев, А.В. Панов, В.В. Суслов, И.В. Сакаева. - № 2012125357/15; заявл. 19.06.2012; опубл. 27.06.2013.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
