pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-313Research ArticleФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИЯPHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGYОСОБЕННОСТИ ФЕРМЕНТАТИВНОГО ВЫСВОБОЖДЕНИЯ ИЗ БИОСОВМЕСТИМЫХ МИКРОКАПСУЛ СО ВСТРОЕННЫМ В ОБОЛОЧКУ ИНГИБИТОРОМ ПЕПТИДАЗЫFEATURES ENZYMATIC RELEASE BIOCOMPATIBLE MICROCAPSULES WITH BUILT-IN SHELL INHIBITOR PEPTIDASEПоповаЕ. В.PopovaE. V.noemail@neicon.ruБельтюковП. П.BeltiukovP. P.noemail@neicon.ruКузнецовВ. А.KuznetsovV. A.noemail@neicon.ruПетуновС. Г.PetunovS. G.noemail@neicon.ruРадиловА. С.RadilovA. S.noemail@neicon.ruФГУП НИИ гигиены, профпатологии и экологии человека ФМБА РоссииFederal State Unitary Enterprise Research Institute of Hygiene, Occupational and Human Ecology FMBA201709012019015257Copyright © Попова Е.В., Бельтюков П.П., Кузнецов В.А., Петунов С.Г., Радилов А.С., 20192019Попова Е.В., Бельтюков П.П., Кузнецов В.А., Петунов С.Г., Радилов А.С.Popova E.V., Beltiukov P.P., Kuznetsov V.A., Petunov S.G., Radilov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/313

Микрокапсулы, содержащие поли(аллил)амина гидрохлорид (PAH), были получены послойной адсорбцией бы­чьего сывороточного альбумина и дубильной кислоты на CaCO3-микрочастицах (ядрах) с их последующим растворением при помощи этилендиаминтетрауксусной кислоты (ЭДТА). Включение PAH проводили методом соосаждения. Изучена ки­нетика высвобождения PAH из микрокапсул в среде с щелочными значениями pH и трипсином. Продемонстрирована возможность регулирования высвобождения PAH из микрокапсул путем варьирования состава их оболочки (введение в оболочку овомукоида).

Microcapsules consisted of biocompatible components- bovine serum albumin and tannic acid were made using Layer-by-Layer encapsulation method. Process of microcapsule formation was studied. Poly(allyl)amine hydrochloride (PAH) was included into the microcapsules and process of its release into medium with neutral and alkaline pH and trypsin was studied. The ability to control release of model substance PAH from these capsules with the help of trypsin was shown.

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The authors declare that there are no conflicts of interest present.