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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pharmjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Разработка и регистрация лекарственных средств</journal-title><trans-title-group xml:lang="en"><trans-title>Drug development &amp; registration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-2066</issn><issn pub-type="epub">2658-5049</issn><publisher><publisher-name>LLC «CPHA»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pharmjournal-315</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGY</subject></subj-group></article-categories><title-group><article-title>ОПТИМИЗАЦИЯ ТЕХНОЛОГИИ ПОЛУЧЕНИЯ β-КАРОТИНА МЕТОДОМ МАТЕМАТИЧЕСКОГО ПЛАНИРОВАНИЯ ЭКСПЕРИМЕНТА</article-title><trans-title-group xml:lang="en"><trans-title>TECHNOLOGY OPTIMIZATION OF β-CAROTENE PRODUCTION BY MEANS OF MATHEMATICAL DESIGN OF EXPERIMENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курегян</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuregyan</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Э. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>E. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пятигорский медико-фармацевтический институт - филиал ГБОУ ВПО ВолгГМУ Минздрава России</institution></aff><aff xml:lang="en"><institution>Pyatigorsk Medical and Pharmaceutical Institute - a branch of SEI HPE Volgograd state medical university MH RF</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2019</year></pub-date><volume>0</volume><issue>1</issue><fpage>66</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Курегян А.Г., Степанова Э.Ф., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Курегян А.Г., Степанова Э.Ф.</copyright-holder><copyright-holder xml:lang="en">Kuregyan A.G., Stepanova E.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmjournal.ru/jour/article/view/315">https://www.pharmjournal.ru/jour/article/view/315</self-uri><abstract><p>В настоящей статье представлены результаты моделирования и оптимизации процесса получения каротиноидов на примере β-каротина. Проведена комплексная количественная оценка влияния пяти технологических параметров на выход индивидуального каротиноида методом математического планирования эксперимента. Цель достигнута путем построения математической модели на основе уравнения регрессии первого порядка. Доказана адекватность работы полученной математической модели и проведена оптимизация процесса получения β-каротина методом крутого восхождения.</p></abstract><trans-abstract xml:lang="en"><p>This article presents the results of modeling and optimization of the process of producing carotenoids by the example of β-carotene. The complex quantitative estimation of five technological parameters influence on the exit of individual carotenoid is conducted by the method of the mathematical planning of experiment. The complex quantitative estimation of influence of five technological parameters is conducted on the exit of individual carotenoids the method of the mathematical planning of experiment. The goal is achieved by constructing a mathematical model based on regression equations of the first order. We prove the adequacy of the work produced mathematical models and optimization carried out the process of obtaining β-carotene by a steep ascent.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>каротиноиды</kwd><kwd>экстракция</kwd><kwd>математическое планирование эксперимента</kwd><kwd>крутое восхождение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>carotenoids</kwd><kwd>β-carotene</kwd><kwd>extraction</kwd><kwd>mathematical design experiment</kwd><kwd>steep ascent</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">J. Pilbrow, D. Garama, A. Carne. Carotenoid-binding proteins; accessories to carotenoid function // Paper in Press. 2012. V. 59. № 190. Р. 1-3.</mixed-citation><mixed-citation xml:lang="en">J. Pilbrow, D. Garama, A. Carne. Carotenoid-binding proteins; accessories to carotenoid function // Paper in Press. 2012. V. 59. № 190. Р. 1-3.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">J. Deng, L. Xiong, Z. Zuo. Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice // J. Neurosci. Res. 2015. V. 93. Р. 615-622.</mixed-citation><mixed-citation xml:lang="en">J. Deng, L. Xiong, Z. Zuo. Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice // J. Neurosci. Res. 2015. V. 93. Р. 615-622.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">M.A. Gammone, N. D'Orazio. Anti-obesity activity of the marine carotenoid fucoxanthin // Mar. Drugs. 2015. V. 13. Р. 2196-2214.</mixed-citation><mixed-citation xml:lang="en">M.A. Gammone, N. D'Orazio. Anti-obesity activity of the marine carotenoid fucoxanthin // Mar. Drugs. 2015. V. 13. Р. 2196-2214.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">В.Д. Пономарев. Экстрагирование лекарственного сырья. - М.: Медицина, 1976. С. 164-184.</mixed-citation><mixed-citation xml:lang="en">В.Д. Пономарев. Экстрагирование лекарственного сырья. - М.: Медицина, 1976. С. 164-184.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">В.Д. Пономарев, В.Г. Беликов, Н.И. Коковкин-Щербак. Математические методы в фармации. - М.: Медицина, 1983. С. 101-150.</mixed-citation><mixed-citation xml:lang="en">В.Д. Пономарев, В.Г. Беликов, Н.И. Коковкин-Щербак. Математические методы в фармации. - М.: Медицина, 1983. С. 101-150.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Я.И. Абрамова, В.С. Чучалин, Е.М. Теплякова и др. Разработка технологии экстракта желчегонного сбора // Фармация. 2012. № 2. С. 38-41.</mixed-citation><mixed-citation xml:lang="en">Я.И. Абрамова, В.С. Чучалин, Е.М. Теплякова и др. Разработка технологии экстракта желчегонного сбора // Фармация. 2012. № 2. С. 38-41.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">ОФС.1.1.0013.15. Статистическая обработка результатов химического эксперимента // Государственная фармакопея РФ, 13-е изд. - М.: НЦЭСМП, 2015. URL: http://www.femb.ru.</mixed-citation><mixed-citation xml:lang="en">ОФС.1.1.0013.15. Статистическая обработка результатов химического эксперимента // Государственная фармакопея РФ, 13-е изд. - М.: НЦЭСМП, 2015. URL: http://www.femb.ru.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
