pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-408Research ArticleФАРМАЦЕВТИЧЕСКАЯ ТЕХНОЛОГИЯ И НАНОТЕХНОЛОГИИPHARMACEUTICAL TECHNOLOGY AND NANOTECHNOLOGYКАЛОРИМЕТРИЧЕСКОЕ ПОЛУЧЕНИЕ ЛЕКАРСТВЕННОЙ ФОРМЫ ПАРАЦЕТАМОЛАCALORIMETRIC OBTAINING OF PHARMACEUTICAL FORM OF PARACETOMOLБеляевА. П.BelyaevA. P.noemail@neicon.ruРубецВ. П.RubetsV. P.noemail@neicon.ruАнтиповВ. В.AntipovV. V.noemail@neicon.ruСанкт-Петербургская государственная химико-фармацевтическая академияDepartment of Physical and Colloidal Chemistry. Saint-Petersburg State Chemical Pharmaceutical AcademyСанкт-Петербургский технологический институт (технический университет)Department of Analytical Chemistry. Saint Petersburg State Institute of Technology (Technical University)201709012019026264Copyright © Беляев А.П., Рубец В.П., Антипов В.В., 20192019Беляев А.П., Рубец В.П., Антипов В.В.Belyaev A.P., Rubets V.P., Antipov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/408

Исследована возможность получения парацетамола ромбической модификации методом калориметрии. Исследования включали в себя технологические эксперименты, оптическую микроскопию, дифференциальную сканирующую калориметрию, рентгенографию и инфракрасную спектроскопию. Установлено, что в результате циклического воздействия температуры кристаллы парацетамола модифицируются в кристаллы ромбической сингонии, обладающие по сравнению с моноклинной кристаллической структурой повышенными технологическими параметрами. Представлены микрофотографии, рентгенограммы, кривые дифференциальной сканирующей спектроскопии и спектры поглощения.

The possibility of formation of paracetamol of orthorhombic modification by the method of calorimetry is studied. The studies include technological experiments, optical microscopy, differential scanning calorimetry, X-ray diffraction and IR spectroscopy. It is found that in the result of temperature cycling the crystals of paracetamol are modified in the crystals of orthorhombic syngony. Microphotographs, X-ray diffraction patterns, differential scanning spectroscopy curves and absorption spectra are presented.

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The authors declare that there are no conflicts of interest present.