pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-424Research ArticleАНАЛИТИЧЕСКИЕ МЕТОДИКИ И МЕТОДЫ КОНТРОЛЯANALYTICAL AND QUALITY CONTROL METHODSОПРЕДЕЛЕНИЕ ПОЛИСОРБАТОВ В БИОТЕХНОЛОГИЧЕСКИХ ПРЕПАРАТАХDETERMINATION OF POLYSORBATE IN BIOTECH DRUGSГроховскийВ. И.GrokhovskiyV. I.noemail@neicon.ruБендрышевА. А.BendryshevA. A.noemail@neicon.ruШвецС. В.ShvetsS. V.noemail@neicon.ruОрловД. А.OrlovD. A.noemail@neicon.ruВагановаО. А.VaganovaO. A.noemail@neicon.ruФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииScientific Center for Expertise of Medicinal products, Ministry of Healthcare20170901201902160165Copyright © Гроховский В.И., Бендрышев А.А., Швец С.В., Орлов Д.А., Ваганова О.А., 20192019Гроховский В.И., Бендрышев А.А., Швец С.В., Орлов Д.А., Ваганова О.А.Grokhovskiy V.I., Bendryshev A.A., Shvets S.V., Orlov D.A., Vaganova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/424

Статья представляет собой обзор публикаций, посвященных количественному определению полисорбатов в лекарственных препаратах. В статье затронуты вопросы строения и свойств полисорбатов. Рассмотрен вопрос применения полисорбатов в производстве лекарственных препаратов. Оценены подходы и методы количественного определения полисорбатов, приведены их достоинства и недостатки.

The article is a review of publications on the quantitative determination of polysorbates in pharmaceuticals. The author touches upon the structure and properties of polysorbates. The question of the use of polysorbates in the production of drugs is considered. Approaches and methods for quantitative determination of polysorbates are evaluated, their advantages and disadvantages are indicated.

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The authors declare that there are no conflicts of interest present.