pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-437Research ArticleЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ЛЕКАРСТВЕННЫХ СРЕДСТВDRUG PRODUCTS EFFICACY AND SAFETYСПОСОБЫ СТАБИЛИЗАЦИИ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ И ИХ МЕТАБОЛИТОВ В БИОЛОГИЧЕСКИХ ЖИДКОСТЯХ ПРИ БИОАНАЛИТИЧЕСКИХ ИССЛЕДОВАНИЯХ (ОБЗОР)METHODS OF STABILIZATION OF DRUG SUBSTANCES AND THEIR METABOLITES IN BIOLOGICAL FLUIDS DURING BIOANALYTICAL STUDY (REVIEW)ЯичковИ. И.YaichkovI. I.noemail@neicon.ruХохловА. Л.KhokhlovA. L.noemail@neicon.ruДжуркоЮ. А.DzhurkoY. A.noemail@neicon.ruШитовЛ. Н.ShitovL. N.noemail@neicon.ruТрубниковА. А.TrubnikovA. A.noemail@neicon.ruФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава РоссииYaroslavl State Medical University of the Ministry of health of the Russian FederationООО «Квинта-Аналитика Ярославль»Quinta-Analytica Yaroslavl LLCООО «Квинта-Аналитика Ярославль»Yaroslavl State Medical University of the Ministry of health of the Russian Federation; Quinta-Analytica Yaroslavl LLC20170901201902246250Copyright © Яичков И.И., Хохлов А.Л., Джурко Ю.А., Шитов Л.Н., Трубников А.А., 20192019Яичков И.И., Хохлов А.Л., Джурко Ю.А., Шитов Л.Н., Трубников А.А.Yaichkov I.I., Khokhlov A.L., Dzhurko Y.A., Shitov L.N., Trubnikov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/437

В статье рассмотрены основные способы предотвращения разложения химически нестабильных лекарственных веществ и их метаболитов в биологических жидкостях в процессе хранения после отбора у пациентов, что необходимо для точного количественного определения данных соединений.

This article describes main methods of preventing degradation of chemically unstable drugs and their metabolites in biological fluids during storage after collection from patients. It is necessary for accurate quantitative determination of these compounds.

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The authors declare that there are no conflicts of interest present.