pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-505Research ArticleАНАЛИТИЧЕСКИЕ МЕТОДИКИ И МЕТОДЫ КОНТРОЛЯANALYTICAL AND QUALITY CONTROL METHODSМЕТОДЫ ОБНАРУЖЕНИЯ ТОКСИКАНТОВ С ИСПОЛЬЗОВАНИЕМ ЛЮМИНЕСЦЕНТНЫХ РЕАГЕНТОВDETECTION OF TOXICANTS BASED ON LUMINESCENT REAGENTSСосновА. В.SosnovA. V.noemail@neicon.ruВласовМ. И.VlasovM. I.noemail@neicon.ruСадовниковС. В.SadovnikovS. V.noemail@neicon.ruРуфановК. А.RufanovK. A.noemail@neicon.ruСемченкоФ. М.SemchenkoF. M.noemail@neicon.ruСосноваА. А.SosnovaA. A.noemail@neicon.ruРадиловА. С.RadilovA. S.noemail@neicon.ruСавельеваЕ. И.SavelievaE. I.noemail@neicon.ruФГУП «Государственный завод медицинских препаратов» (ФГУП «ГосЗМП»)Federal State Unitary Enterprise «State Pharmaceutical Plant» (FSUE «GosZMP»)ФГУП «Научно-исследовательский институт гигиены, профпатологии и экологии человека» (ФГУП «НИИ ГПЭЧ» ФМБА России)Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical-Biological Agency of Russia20170901201904108124Copyright © Соснов А.В., Власов М.И., Садовников С.В., Руфанов К.А., Семченко Ф.М., Соснова А.А., Радилов А.С., Савельева Е.И., 20192019Соснов А.В., Власов М.И., Садовников С.В., Руфанов К.А., Семченко Ф.М., Соснова А.А., Радилов А.С., Савельева Е.И.Sosnov A.V., Vlasov M.I., Sadovnikov S.V., Rufanov K.A., Semchenko F.M., Sosnova A.A., Radilov A.S., Savelieva E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/505

Описано и систематизировано использование люминесцентных реагентов для определения токсикантов, включая отравляющие вещества, пестициды, продукты их деструкции и прекурсоры. На примере фосфорорганических токсикантов и продуктов их деструкции (ФОВ) показано, что чувствительность люминесцентных методов на основе органических комплексов лантаноидов (в первую очередь Eu3+) находится на уровне наиболее совершенных инструментальных хроматографических и биохимических методов анализа с пределом определения на уровне единиц ppt, что позволяет определять супертоксиканты на уровне требований безопасности, время анализа - от нескольких секунд до 10 мин. Высокая селективность идентификации достигается за счет использования импринтированных материалов, модифицированных циклодекстринов, а так же люминесцентных сенсорных матриц. Это является основой разработки новых технологий индикации следов токсикантов и продуктов их разложения, включая возможную технологию использования люминесцентных контрастных реагентов для увеличения чувствительности спектральных методов и дистанционного определения токсикантов. Показаны возможности разработки принципиально новых материалов для индивидуальных средств защиты, оборудования и мультифункциональных контактных поверхностей, обеспечивающих визуализацию и идентификацию токсикантов, а так же каталитическую самодегазацию. Продемонстрирована взаимосвязь технологий обеспечения безопасности людей и окружающей среды на стыке аналитической химии, криминалистики, химической безопасности и фармацевтики.

Application of luminescent reagents for detection of toxicants including warfare agents, pesticides and their degradation products and precursors has been systematically reviewed. Methods of organophosphorus toxicants and products of their destruction (OP) detection based on lanthanide luminescent complexes (primarily Eu3+) have the similar sensitivity as the most advanced instrumental chromatographic and biochemical assays with detection level in the range of several ppts that allows to determine supertoxicants at the safety requirements concentration levels and at appropriate analysis duration from a few seconds to 10 minutes. High selectivity of toxicants identification is achieved by means of imprinted materials, modified cyclodextrins and luminescent sensor arrays. This is the basis for development of new technologies for trace analysis of toxicants and their decomposition products, including possible technology of luminescent contrast agents’ application to increase sensitivity of spectroscopic methods and remote determination of toxicants on the ground. Further possibilities to develop next generation materials for protective gear, equipment and multifunctional contact surfaces providing visualization and identification of toxicants and simultaneous catalytic self-decontamination is discussed. Relationship between technologies for improving safety and security at the crossroads of analytical chemistry of warfare agents, criminalistics, chemical safety and pharmaceutics has been demonstrated.

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The authors declare that there are no conflicts of interest present.