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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pharmjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Разработка и регистрация лекарственных средств</journal-title><trans-title-group xml:lang="en"><trans-title>Drug development &amp; registration</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-2066</issn><issn pub-type="epub">2658-5049</issn><publisher><publisher-name>LLC «CPHA»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pharmjournal-523</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ЛЕКАРСТВЕННЫХ СРЕДСТВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DRUG PRODUCTS EFFICACY AND SAFETY</subject></subj-group></article-categories><title-group><article-title>ИССЛЕДОВАНИЕ ДЕЙСТВИЯ СЕЛЕКТИВНОГО АКТИВАТОРА Сa-ЗАВИСИМОЙ NO-СИНТАЗЫ НА ГЕМОСТАЗ У ЛАБОРАТОРНЫХ ЖИВОТНЫХ</article-title><trans-title-group xml:lang="en"><trans-title>INVESTIGATION OF A CA-DEPENDENT INDUCER ON HEMOSTASIS PROPERTIES IN LABORATORY ANIMALS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Станишевский</surname><given-names>Я. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Stanishevskiy</surname><given-names>Ya. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов» (РУДН)<country>Россия</country></aff><aff xml:lang="en">Peoples’ Friendship University of Russia (RUDN University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУН Институт теоретической и экспериментальной биофизики РАН (ИТЭБ РАН)<country>Россия</country></aff><aff xml:lang="en">Institute of Theoretical and Experimental Biophysics (ITEB) RAS<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2019</year></pub-date><volume>0</volume><issue>4</issue><fpage>244</fpage><lpage>246</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлова В.С., Орлова Е.В., Петрова О.В., Станишевский Я.М., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Орлова В.С., Орлова Е.В., Петрова О.В., Станишевский Я.М.</copyright-holder><copyright-holder xml:lang="en">Orlova V.S., Orlova E.V., Petrova O.V., Stanishevskiy Y.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmjournal.ru/jour/article/view/523">https://www.pharmjournal.ru/jour/article/view/523</self-uri><abstract><p>В работе показано влияние нового препарата - селективного активатора Са-зависимой NO-синтазы на процессы гемостаза в норме и при диабете 2 типа у лабораторных животных.</p></abstract><trans-abstract xml:lang="en"><p>The effect of a new drug - selective activator of Ca-dependent NO-synthase on the processes of hemostasis in norm and type 2 diabetes in laboratory animals is shown in this paper.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гемостаз</kwd><kwd>диабет 2 типа</kwd><kwd>Са-зависимая NO -синтаза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hemostasis</kwd><kwd>type 2 diabetes</kwd><kwd>Ca-dependent NO-synthase</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">А.С. 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