pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-554Research ArticleАНАЛИТИЧЕСКИЕ МЕТОДИКИ И МЕТОДЫ КОНТРОЛЯANALYTICAL AND QUALITY CONTROL METHODSРАЗРАБОТКА НЕИНЪЕКЦИОННЫХ ПРЕПАРАТОВ ЦЕНТРАЛЬНОГО ДЕЙСТВИЯ ДЛЯ НЕОТЛОЖНОЙ ТЕРАПИИDEVELOPMENT OF NON-INJECTABLE MEDICINAL DRUGS ACTING ON CNS FOR EMERGENCY THERAPYСосновА. В.SosnovA. V.noemail@neicon.ruСемченкоФ. М.SemchenkoF. M.noemail@neicon.ruВласовМ. И.VlasovM. I.noemail@neicon.ruТохмахчиВ. Н.TohmahchiV. N.noemail@neicon.ruСосноваА. А.SosnovaA. A.noemail@neicon.ruКинзирскийА. С.KinzirskyA. S.noemail@neicon.ruФГУП «Государственный завод медицинских препаратов» (ФГУП «ГосЗМП»)Federal State Unitary Enterprise «State Pharmaceutical Plant» (FSUE «GosZMP»); Institute of Physiologically Active Compounds Russian Academy of SciencesФГУП «Государственный завод медицинских препаратов» (ФГУП «ГосЗМП»)Federal State Unitary Enterprise «State Pharmaceutical Plant» (FSUE «GosZMP»)ФГБУН Институт физиологически активных веществ Российской академии наук (ИФАВ РАН)Institute of Physiologically Active Compounds Russian Academy of Sciences20180901201901114133Copyright © Соснов А.В., Семченко Ф.М., Власов М.И., Тохмахчи В.Н., Соснова А.А., Кинзирский А.С., 20192019Соснов А.В., Семченко Ф.М., Власов М.И., Тохмахчи В.Н., Соснова А.А., Кинзирский А.С.Sosnov A.V., Semchenko F.M., Vlasov M.I., Tohmahchi V.N., Sosnova A.A., Kinzirsky A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/554

На примере сильнодействующих анальгетиков обоснован алгоритм выбора соединений и лекарственных форм для разработки универсальных ЦНС-таргетных препаратов для неотложной военно-полевой и гражданской терапии. Выделены ключевые критерии и количественные параметры выбора веществ и лекарственных форм. Продемонстрированы преимущества сильнодействующих синтетических опиоидов относительно традиционно используемого морфина, его производных и аналогов. Показаны преимущества мультитаргетных препаратов. Обоснован выбор трансмукозных лекарственных форм анальгетиков, противорвотных средств и антидотов для неотложной терапии. Предложены подходы к разработке универсальной фармакологической платформы для создания ЦНС-направленных средств терапии. Описана текущая ситуация в области сильнодействующих анальгетиков и других лекарств ограниченного использования в РФ, отмечены проблемы и предложены возможные решения.

Algorithm of selection of compounds and formulations for development of multi-purpose CNS targeted medicinal products for emergency field and civil therapy is justified on the example of potent analgesics. Key criteria and quantitative parameters for selection of substances and dosage forms are singled out. The advantages of strong synthetic opioids vs traditionally used morphine, its derivatives and analogues are demonstrated. Advantages of multi-target formulations are shown. Choice of transmucosal dosage forms of analgesics, antiemetics and antidotes for urgent therapy is substantiated. Approaches to development of universal pharmacological platform for creating drugs acting on CNS are proposed. The current situation in the field of potent analgesics and other limited use medicines in the Russian Federation is described, problems are noted and possible solutions are suggested.

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The authors declare that there are no conflicts of interest present.