pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-615Research ArticleАНАЛИТИЧЕСКИЕ МЕТОДИКИ И МЕТОДЫ КОНТРОЛЯANALYTICAL AND QUALITY CONTROL METHODSПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ФИТОТЕРАПЕВТИЧЕСКИХ СРЕДСТВ ПРИ НАРУШЕНИЯХ ЖИРОВОГО И УГЛЕВОДНОГО ОБМЕНОВPROSPECTS OF USING PHYTOTHERAPY AT DISORDERS OF FAT AND CARBOHYDRATE METABOLISMПовыдышМ. Н.PovydyshM. N.noemail@neicon.ruЛужанинВ. Г.LuzhaninV. G.noemail@neicon.ruИвкинД. Ю.IvkinD. Yu.noemail@neicon.ruБелоусовМ. В.BelousovM. V.noemail@neicon.ruЯковлевГ. П.YakovlevG. P.noemail@neicon.ruФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской ФедерацииРоссияSaint-Petersburg State Chemical and Pharmaceutical UniversityRussian FederationФГБОУ ВО «Сибирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical UniversityRussian Federation20180901201903130135Copyright © Повыдыш М.Н., Лужанин В.Г., Ивкин Д.Ю., Белоусов М.В., Яковлев Г.П., 20192019Повыдыш М.Н., Лужанин В.Г., Ивкин Д.Ю., Белоусов М.В., Яковлев Г.П.Povydysh M.N., Luzhanin V.G., Ivkin D.Y., Belousov M.V., Yakovlev G.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/615

В обзоре приведено описание и результаты первого этапа фитофармакологического поиска - сбора информации о перспективных видах лекарственного растительного сырья (ЛРС), суммарных извлечениях и индивидуальных веществах растительного происхождения, которые обладают выраженной фармакологической активностью при нарушениях жирового и углеводного обменов, в том числе при ожирении, сахарном диабете 2 типа (СД2), метаболическом синдроме (МС) и неалкогольной жировой болезни печени (НАЖБП), подтверждённой в доклинических и/или клинических исследованиях.

The review describes the first stage of phyto-pharmacological screening. It includes literature data analysis on promising species of medicinal plant raw materials, total extracts and individual substances of plant origin with pronounced pharmacological activity in disorders of fat and carbohydrate metabolism, incl. obesity, diabetes mellitus type 2, metabolic syndrome, and non-alcoholic fatty liver disease, confirmed in preclinical and/or clinical trials.

лекарственное растительное сырьёметаболический синдроминдивидуальные вещества растительного происхоженияmedicinal plant raw materialsmetabolic syndromeindividual substances of plant originReferencesNewman D. J., Cragg G. M. Natural products as sources of new drugs from 1981 to 2014 // J. Nat. Prod. 2016. Т. 79. № 3. Р. 629-661.Newman D. J., Cragg G. M. Natural products as sources of new drugs from 1981 to 2014 // J. Nat. Prod. 2016. Т. 79. № 3. Р. 629-661.Newman D. J., Cragg G. M., Snader K. M. The influence of natural products upon drug discovery // Natural product reports. 2000. V. 17. № 3. Р. 215-234.Newman D. J., Cragg G. M., Snader K. M. The influence of natural products upon drug discovery // Natural product reports. 2000. V. 17. № 3. Р. 215-234.Aslam M. S., Ahmad M. S. Worldwide importance of medicinal plants: current and historical perspectives // Recent Adv. Biol. Med. 2016. V. 2. Р. 88-93.Aslam M. S., Ahmad M. S. Worldwide importance of medicinal plants: current and historical perspectives // Recent Adv. Biol. Med. 2016. V. 2. Р. 88-93.Калмыков С., Калмыкова Ю. Характеристика лекарственных растений, применяемых в фитотерапии сахарного диабета 2-го типа // Слобожанський науково-спортивний вісник. 2016. № 3(53). C. 53-58.Kalmykov S., Kalmykova Yu. Description of medicinal plants used in phytotherapy of type 2 diabetes mellitus // Slobozhansky science and sports journal. 2016. № 3(53). S. 53-58.Sheweita S. A. et al. Changes in oxidative stress and antioxidant enzyme activities in streptozotocin-induced Diabetes mellitus in rats: Role of Alhagi maurorum extracts // Oxidative medicine and cellular longevity. 2016. V. 2016. P. 8.Sheweita S. A. et al. Changes in oxidative stress and antioxidant enzyme activities in streptozotocin-induced Diabetes mellitus in rats: Role of Alhagi maurorum extracts // Oxidative medicine and cellular longevity. 2016. V. 2016. P. 8.Lui T. N. et al. Activation of imidazoline I 2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C 2 C 12 cells // Neuroscience letters. 2010. V. 474. № 3. Р. 144-147.Lui T. N. et al. Activation of imidazoline I 2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C 2 C 12 cells // Neuroscience letters. 2010. V. 474. № 3. Р. 144-147.Lupak M. I. et al. The alkaloid-free fraction from Galega officinalis extract prevents oxidative stress under experimental diabetes mellitus // Ukrainian biochemical journal. 2015. V. 87. № 4. Р. 78-86.Lupak M. I. et al. The alkaloid-free fraction from Galega officinalis extract prevents oxidative stress under experimental diabetes mellitus // Ukrainian biochemical journal. 2015. V. 87. № 4. Р. 78-86.Останова H. А., Пряхина H. И. Некоторые фармакологические свойства надземной части Galega officinalis L. и G. orientalis Lam // Растительные ресурсы. 2003. Т. 39. № 4. С. 119-129.Ostanova H. A., Prjahina H. I. Some pharmacological properties of the aerial part of Galega officinalis L. and G. orientalis Lam // Plant resources. 2003. T. 39. № 4. S. 119-129.Якимова Т. В. и др. Гипогликемическое действие экстракта из Galega officinalis (Fabaceae), культивируемой на Алтае // Растительные ресурсы. 2005. Т. 41. № 2. С. 134-138.Jakimova T. V. i dr. Hypoglycemic action of extract from Galega officinalis (Fabaceae), cultivated in Altai // Plant resources. 2005. T. 41. № 2. S. 134-138.Lui T. N. et al. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells //Neuroscience letters. - 2010. V. 474. № 3. Р. 144-147.Lui T. N. et al. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells //Neuroscience letters. - 2010. V. 474. № 3. Р. 144-147.Christensen K. B. et al. Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake // Phytotherapy research. 2009. V. 23. № 9. Р. 1316-1325.Christensen K. B. et al. Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake // Phytotherapy research. 2009. V. 23. № 9. Р. 1316-1325.Palit P., Furman B. L., Gray A. I. Novel weight reducing activity of Galega officinalis in mice // Journal of pharmacy and pharmacology. 1999. V. 51. № 11. Р. 1313-1319.Palit P., Furman B. L., Gray A. I. Novel weight reducing activity of Galega officinalis in mice // Journal of pharmacy and pharmacology. 1999. V. 51. № 11. Р. 1313-1319.Mooney M. H. et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice // British journal of pharmacology. 2008. V. 153. № 8. Р. 1669-1677.Mooney M. H. et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice // British journal of pharmacology. 2008. V. 153. № 8. Р. 1669-1677.Coxon G. D. et al. Benzylguanidines and other galegine analogues inducing weight loss in mice // Journal of medicinal chemistry. 2009. V. 52. № 11. Р. 3457-3463.Coxon G. D. et al. Benzylguanidines and other galegine analogues inducing weight loss in mice // Journal of medicinal chemistry. 2009. V. 52. № 11. Р. 3457-3463.Плечищик Е. Д., Гончарова Л. В., Спиридович Е. В., Решетников В. Н. Пажитник греческий (Trigonella foenum graecum L.) как источник широкого спектра биологически активных соединений // Труды БГУ. 2010. Т. 4(2). С. 1-9.Plechishhik E. D., Goncharova l. V., Spiridovich E. V., Reshetnikov V. N. Fenugreek (Trigonella foenum graecum L.) as a source of a wide range of biologically active compounds // Proceedings of BSU. 2010. V. 4(2). S. 1-9.Растительные ресурсы России. Т. 4. Семейства Caprifoliaceae - Lobeliaceae. Под ред. А. Л. Буданцева, СПб.; Товарищество научных изданий КМК, 630 с.Plant resources of Russia. V. 4. Families Of Caprifoliaceae – Lobeliaceae. Ed. by L. A. Budantseva, SPb.; Goods- scientific publications of KMC, 630 p.Barrett M. L., Udani J. K. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control // Nutrition Journal. - 2011. V. 10. № 1. Р. 24.Barrett M. L., Udani J. K. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control // Nutrition Journal. - 2011. V. 10. № 1. Р. 24.Spadafranca A. et al. Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects // British Journal of Nutrition. 2013. V. 109. № 10. P. 1789-1795.Spadafranca A. et al. Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects // British Journal of Nutrition. 2013. V. 109. № 10. P. 1789-1795.Tan Y., Chang S. K. C., Zhang Y. Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera // Food chemistry. 2017. V. 214. P. 259-268.Tan Y., Chang S. K. C., Zhang Y. Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera // Food chemistry. 2017. V. 214. P. 259-268.Mojica L., de Mejía E. G. Optimization of enzymatic production of anti-diabetic peptides from black bean (Phaseolus vulgaris L.) proteins, their characterization and biological potential // Food & function. 2016. V. 7. № 2. P. 713-727.Mojica L., de Mejía E. G. Optimization of enzymatic production of anti-diabetic peptides from black bean (Phaseolus vulgaris L.) proteins, their characterization and biological potential // Food & function. 2016. V. 7. № 2. P. 713-727.Lomas-Soria C. et al. Cooked common beans (Phaseolus vulgaris L.) modulate renal genes in streptozotocin-induced diabetic rats //The Journal of nutritional biochemistry. 2015. V. 26. № 7. P. 761-768.Lomas-Soria C. et al. Cooked common beans (Phaseolus vulgaris L.) modulate renal genes in streptozotocin-induced diabetic rats //The Journal of nutritional biochemistry. 2015. V. 26. № 7. P. 761-768.Okada Y., Okada M., Sagesaka Y. Screening of dried plant seed extracts for adiponectin production activity and tumor necrosis factor-alpha inhibitory activity on 3T3-L1 adipocytes // Plant foods for human nutrition. 2010. V. 65. № 3. P. 225-232.Okada Y., Okada M., Sagesaka Y. Screening of dried plant seed extracts for adiponectin production activity and tumor necrosis factor-alpha inhibitory activity on 3T3-L1 adipocytes // Plant foods for human nutrition. 2010. V. 65. № 3. P. 225-232.Растительные ресурсы России. Дикорастущие цветковые растения, их компонентный состав и биологическая активность. Т. 5. Семейство Asteraceae (Compositae). Часть 1. Роды Asteraceae (Compositae). Часть 1. Роды Achillea- Doronicum / Под ред. Буданцева А. Л. - СПб.: Товарищество научных изданий КМК. 320 с.Rastitel’nye resursy Rossii. Dikorastushhie cvetkovye rastenija, ih komponentnyj sostav i biologicheskaja aktivnost’. T. 5. Semejstvo Asteraceae (Compositae). Chast’ 1. Rody Achillea- Doronicum / Pod red. Budanceva A. L. - SPb.: Tovarishhestvo nauchnyh izdanij KMK. 320 s.Hosseini M., Asgary S., Najafi S. Inhibitory potential of pure isoflavonoids, red clover, and alfalfa extracts on hemoglobin glycosylation // ARYA atherosclerosis. 2015. V. 11. № 2. P. 133.Hosseini M., Asgary S., Najafi S. Inhibitory potential of pure isoflavonoids, red clover, and alfalfa extracts on hemoglobin glycosylation // ARYA atherosclerosis. 2015. V. 11. № 2. P. 133.Растительные ресурсы России. Т. 3. Семейства Fabaceae - Apiaceae / Под ред. Буданцева А. Л., - СПб.: Товарищество научных изданий КМК. 604 с.Rastitel’nye resursy Rossii. T. 3. Semejstva Fabaceae - Apiaceae / Pod red. Budanceva A. L. - SPb.: Tovarishhestvo nauchnyh izdanij KMK. 604 s.Mahato S. B., Garai S. Triterpenoid saponins // Fortschritte der Chemie organischer Naturstoffe // Progress in the Chemistry of Organic Natural Products. - Vienna: Springer, 1998. P. 1-196.Mahato S. B., Garai S. Triterpenoid saponins // Fortschritte der Chemie organischer Naturstoffe // Progress in the Chemistry of Organic Natural Products. - Vienna: Springer, 1998. P. 1-196.Dushkin et al. Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats // BMC Complementar y and Alternative Medicine. 2014. V. 14. P. 33.Dushkin et al. Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats // BMC Complementar y and Alternative Medicine. 2014. V. 14. P. 33.Baghernya M., Nobili V., Blesso C. N., Sahebkar A. Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review // Pharmacological Research. 2017.Baghernya M., Nobili V., Blesso C. N., Sahebkar A. Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review // Pharmacological Research. 2017.Ya-Ling Liu, Lei-Chen Lin, Yu-Tang Tung, Shang-Tse Ho, Yao-Li Chen, Chi-Chen Lin, Jyh-Horng Wu. Rhododendron oldhamii leaf extract improves fatty liver syndrome by increasing lipid oxidation and decreasing the lipogenesis pathway in mice // International Journal of Medical Sciences. 2017. V. 14(9). P. 862-870.Ya-Ling Liu, Lei-Chen Lin, Yu-Tang Tung, Shang-Tse Ho, Yao-Li Chen, Chi-Chen Lin, Jyh-Horng Wu. Rhododendron oldhamii leaf extract improves fatty liver syndrome by increasing lipid oxidation and decreasing the lipogenesis pathway in mice // International Journal of Medical Sciences. 2017. V. 14(9). P. 862-870.Li N. Y., Li X. L., Zhai X. P., Wang Q. Y., Zhang X. W., Zhao F., Wang X. F., Fan J. Y., Bai F., Yu J. Effects of Mongolia Astragali Radix in protecting early cardiac and nephritic functions of patients of hypertension with metabolic syndrome // Zhongguo Zhong Yao Za Zhi. 2016 V. 41(21). P. 4051-4059.Li N. Y., Li X. L., Zhai X. P., Wang Q. Y., Zhang X. W., Zhao F., Wang X. F., Fan J. Y., Bai F., Yu J. Effects of Mongolia Astragali Radix in protecting early cardiac and nephritic functions of patients of hypertension with metabolic syndrome // Zhongguo Zhong Yao Za Zhi. 2016 V. 41(21). P. 4051-4059.Chiva-Blanch G., Badimon L. Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials // Oxidative Medicine and Cellular Longevity. V. 2017. 18 p.Chiva-Blanch G., Badimon L. Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials // Oxidative Medicine and Cellular Longevity. V. 2017. 18 p.Giampieri F., Forbes-Hernandez T. Y., Gasparrini M., Afrin S., Cianciosi D., Reboredo-Rodriguez P., Varela-Lopez A., Quiles J. L., Mezzetti B., Battino M. The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases // Ann. N.Y. Acad. Sci. 2017. V. 1398(1). P. 62-71.Giampieri F., Forbes-Hernandez T. Y., Gasparrini M., Afrin S., Cianciosi D., Reboredo-Rodriguez P., Varela-Lopez A., Quiles J. L., Mezzetti B., Battino M. The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases // Ann. N.Y. Acad. Sci. 2017. V. 1398(1). P. 62-71.Ayoub H. M., McDonald M. R., Sullivan J. A., Tsao R., Platt M., Simpson J., Meckling K. A. The Effect of Anthocyanin-Rich Purple Vegetable Diets on Metabolic Syndrome in Obese Zucker Rats // J Med Food. 2017. Р. 1-10.Ayoub H. M., McDonald M. R., Sullivan J. A., Tsao R., Platt M., Simpson J., Meckling K. A. The Effect of Anthocyanin-Rich Purple Vegetable Diets on Metabolic Syndrome in Obese Zucker Rats // J Med Food. 2017. Р. 1-10.Bhaswant M., Shafie S. R., Mathai M. L., Mouatt P., Brown L. Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats // Nutrition. 2017. V. 9. P. 1261.Bhaswant M., Shafie S. R., Mathai M. L., Mouatt P., Brown L. Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats // Nutrition. 2017. V. 9. P. 1261.Chavushyan V. A., Simonyan K. V., Simonyan R. M., Isoyan A. S., Simonyan G. M., Babakhanyan M. A., Hovhannisyian L. E., Nahapetyan Kh. H., Avetisyan L. G., Simonyan M. A. Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of metabolic disorders caused by fructose // BMC Complementary and Alternative Medicine. 2017. V. 17. P. 540.Chavushyan V. A., Simonyan K. V., Simonyan R. M., Isoyan A. S., Simonyan G. M., Babakhanyan M. A., Hovhannisyian L. E., Nahapetyan Kh. H., Avetisyan L. G., Simonyan M. A. Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of metabolic disorders caused by fructose // BMC Complementary and Alternative Medicine. 2017. V. 17. P. 540.Carrera-Lanestosa A., Moguel-Ordo´n˜ez Y., Segura-Campos M. Stevia rebaudiana Bertoni: A Natural Alternative for Treating Diseases Associated with Metabolic Syndrome // J Med Food. 2017. P. 1-11.Carrera-Lanestosa A., Moguel-Ordo´n˜ez Y., Segura-Campos M. Stevia rebaudiana Bertoni: A Natural Alternative for Treating Diseases Associated with Metabolic Syndrome // J Med Food. 2017. P. 1-11.

The authors declare that there are no conflicts of interest present.