pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-629Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSАНАЛИЗ ВЛИЯНИЯ СУБСТАНЦИЙ РАЗЛИЧНОЙ ПРИРОДЫ НА СЕЛЕКТИВНУЮ АКТИВАЦИЮ Са²⁺-ЗАВИСИМОЙ NO-СИНТАЗЫ (ОБЗОР)ANALYSIS ON THE INFLUENCE OF VARIOUS SUBSTANCES ON SELECTIVE ACTIVATION OF Ca²⁺-DEPENDENT NO-SYNTASE (REVIEW)КокареваЕ. С.KokarevaE. S.noemail@neicon.ruМорозовВ. В.MorozovV. V.noemail@neicon.ruСтанишевскийЯ. М.StanishevskiyYa. M.noemail@neicon.ruЖуравлеваМ. А.ZhuravlevaM. A.noemail@neicon.ruНоздрюхинаН. В.NozdryukhinaN. V.noemail@neicon.ruОрловаВ. С.OrlovaV. S.noemail@neicon.ruОрловаЕ. В.OrlovaE. V.noemail@neicon.ruФГАОУ ВО «Российский университет дружбы народов» (РУДН)Peoples’ Friendship University of Russia (RUDN University)ФГБУН «Институт теоретической и экспериментальной биофизики» РАН (ИТЭБ РАН)Institute of Theoretical and Experimental Biophysics (ITEB) RAS201809012019042328Copyright © Кокарева Е.С., Морозов В.В., Станишевский Я.М., Журавлева М.А., Ноздрюхина Н.В., Орлова В.С., Орлова Е.В., 20192019Кокарева Е.С., Морозов В.В., Станишевский Я.М., Журавлева М.А., Ноздрюхина Н.В., Орлова В.С., Орлова Е.В.Kokareva E.S., Morozov V.V., Stanishevskiy Y.M., Zhuravleva M.A., Nozdryukhina N.V., Orlova V.S., Orlova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/629

В статье представлены сведения о строении, классификации и функциях NO-синтаз. Рассмотрены основные ингибиторы фермента, а также механизмы их действия. Среди веществ активирующих деятельность фермента, особое внимание было уделено веществам нуклеотидно-пептидной природы, на примере субстанции, выделенной из дрожжей Saccharomyces cerevisiae раса 14. Было установлено, что нуклеотидный препарат на основе субстанции, выделенной из дрожжей Saccharomyces cerevisiae раса 14. обладает более выраженным активирующим действием в сравнении с Т-активином, и способствует восстановлению функций фермента при таком заболевании, как сахарный диабет.

The article presents information on the structure, classification and functions of NO-synthases. The main inhibitors of the enzyme, as well as their mechanisms of action, are considered. Among the substances activating the activity of the enzyme, special attention was paid to substances of nucleotide-peptide nature, using the example of a substance isolated from Saccharomyces cerevisiae race 14, it was found that the nucleotide preparation based on a substance isolated from Saccharomyces cerevisiae race 14. has a more pronounced activating action in comparison with T-activin, and helps to restore the functions of the enzyme in diseases such as diabetes.

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The authors declare that there are no conflicts of interest present.