Введение

pharmjournal

Разработка и регистрация лекарственных средств

Drug development & registration

2305-20662658-5049

LLC «CPHA»

10.33380/2305-2066-2019-8-1-43-57

pharmjournal-647

Research Article

МЕТОДЫ АНАЛИЗА ЛЕКАРСТВЕННЫХ СРЕДСТВ

ANALYTICAL METHODS

КЛЕТОЧНЫЕ НОСИТЕЛИ КАК СИСТЕМЫ ДОСТАВКИ ПРОТИВООПУХОЛЕВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ (ОБЗОР)

CELL CARRIERS AS SYSTEMS OF DELIVERY OF ANTITUMOR DRUGS (REVIEW)

Тринеева

О. В.

Trineeva

O. V.

trineevaov@mail.ru

Халахакун

А. Д.

Halahakoon

A. J.

Сливкин

А. И.

Slivkin

A. I.

ФГБОУ ВО «Воронежский государственный университет»РоссияVoronezh State UniversityRussian Federation

2019

14022019

814357

2019

Тринеева О.В., Халахакун А.Д., Сливкин А.И.

Trineeva O.V., Halahakoon A.J., Slivkin A.I.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmjournal.ru/jour/article/view/647

Введение

Введение. Системы доставки лекарственных средств (СДЛС) определяются как системы, которые доставляют оптимальное количество лекарственного средства (ЛС) к целевой мишени, повышают эффективность лечения и уменьшают неблагоприятные последствия. Регулирование скорости высвобождения ЛС и доведение на конкретные ткани, где необходимы действующие вещества, являются основными целями СДЛС. Разработка систем для целенаправленной, органоспецифичной и контролируемой доставки лекарственных, профилактических и диагностических средств представляет собой в настоящее время актуальную область исследования для фармации и медицины. Особый интерес уделяется актуальной проблеме возрастания частоты проявлений побочных действий лекарственных препаратов (ЛП). Побочное действие ЛП, их малая эффективность нередко объясняются труднодоступностью препаратов непосредственно в мишень.

Текст

Текст. В настоящее время адресной доставкой химиотерапевтических веществ и СДЛС полностью изменяется тактика и подходы в медикаментозном лечении рака, позволяющие понижать побочные эффекты препарата и в целом увеличивать эффективность курса лечения. В настоящей работе приведено обобщение и систематизация сведений об адресных СДЛС противоопухолевого действия, описанных в научной литературе и используемых в фармации и медицине. Большинство рассмотренных в данном обзоре методов получения клеточных форм токсичных ЛС пока находится на стадии разработки, а некоторые методы постепенно находят практическое применение за рубежом в медицине и др. областях. Винкристин (VCR) и винбластин (VBL) являются наиболее широко используемыми и эффективными ЛС в химиотерапевтической практике. Несмотря на их эффективность против различных онкологических заболеваний, имеется ряд вредных побочных действий, которые ограничивают широкое применения этих препаратов.

Заключение

Заключение. Существует возможность использования клеточных носителей (КН) в качестве системы доставки VCR и VBL. В научных публикациях пока отсутствуют данные о применении КН для инкапсулирования VCR и VBL. Поэтому актуальны исследования, посвящённые возможности применения КН для уменьшения побочных эффектов, улучшения эффективности и разработки лекарственных форм доставки VCR и VBL в патологические очаги. Данная тематика в настоящее время активно разрабатывается сотрудниками кафедры фармацевтической химии и фармацевтической технологии фармацевтического факультета Воронежского госуниверситета.

Introduction

Introduction. Drug delivery systems are defined as systems that deliver the optimal amount of a drug to a target target, increase the effectiveness of treatment, and reduce adverse effects. Regulation of the rate of release of drugs and bringing to specific tissues where active ingredients are needed are the main objectives of drug delivery systems. The development of systems for targeted, organ-specific and controlled delivery of medicinal, prophylactic and diagnostic agents is currently a relevant area of research for pharmacy and medicine. Of particular interest is the actual problem of increasing the frequency of manifestations of side effects of drugs. The side effect of drugs, their low efficiency is often explained by the inaccessibility of drugs directly to the target.

Text

Text. Currently, targeted delivery of chemotherapeutic agents and drug delivery systems has completely changed the tactics and approaches in the drug treatment of cancer, allowing to reduce the side effects of the drug and generally increase the effectiveness of the course of treatment. This paper summarizes and systematizes information about targeted systems for drug delivery of antitumor activity, described in the scientific literature and used in pharmacy and medicine. Most of the methods for obtaining cellular forms of toxic drugs discussed in this review are still at the development stage, and some methods are gradually finding practical application abroad in medicine and other fields. Vincristine (VCR) and vinblastine (VBL) are the most widely used and effective drugs in chemotherapeutic practice. Despite their effectiveness against various oncological diseases, there are a number of harmful side effects that limit the widespread use of these drugs.

Conclusion

Conclusion. There is the possibility of using cellular carriers as a VCR and VBL delivery system. In scientific publications, there is still no data on the use of cellular carriers for encapsulating VCR and VBL. Therefore, relevant studies are devoted to the possibility of using cellular carriers to reduce side effects, improve efficiency, and develop dosage forms for the delivery of VCR and VBL to pathological foci. This topic is currently being actively developed by members of the Department of Pharmaceutical Chemistry and Pharmaceutical Technology, Pharmaceutical Faculty, Voronezh State University.

направленный транспорт лекарственных веществклеточные носителисистемы доставки лекарственных средстввинкристинвинбластин

directional transport of medicinal substancescellular carriersdrug delivery systemsvincristinevinblastine

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The authors declare that there are no conflicts of interest present.