pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»10.33380/2305-2066-2020-9-2-33-44pharmjournal-767Research ArticleПОИСК И РАЗРАБОТКА НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВRESEARCH AND DEVELOPMENT OF NEW DRUG PRODUCTSПерспектива создания лекарственных препаратов на основе наночастиц селена (обзор)The Prospect of Creating Medicines Based on Selenium Nanoparticles (Review)СкориноваК. Д.SkorinovaK. D.

Скоринова Кристина Довлетовна

Кафедра Биохимической технологии и нанотехнологии

117198, г. Москва, ул. Миклухо-Маклая, д. 6

Kristina D. Skorinova  

6, Mikluho-Maklaya str., Moscow, 117198

kristina.skorinova@gmail.comКузьменкоВ. В.KuzmenkoV. V.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

Valeriya V. Kuzmenko  

6, Mikluho-Maklaya str., Moscow, 117198

ВасиленкоА. И.VasilenkoI. A.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

Ivan A. Vasilenko  

6, Mikluho-Maklaya str., Moscow, 117198

ФГАОУ ВО «Российский университет дружбы народов» (Российский университет дружбы народов, РУДН)Peoples Friendship University of Russia (RUDN University)202014052020923344Copyright © Скоринова К.Д., Кузьменко В.В., Василенко А.И., 20202020Скоринова К.Д., Кузьменко В.В., Василенко А.И.Skorinova K.D., Kuzmenko V.V., Vasilenko I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/767Введение

Введение. В настоящее время в литературе широко обсуждаются перспективы использования наночастиц при создании лекарственных препаратов. Количество регистрационных удостоверений, выданных национальными регуляторами только за 2018 год на лекарственные препараты, в которых наночастицы используются в том или ином виде, составляет около сорока. Большинство из них составляют лекарственные препараты на основе липосом, полимеров, оксидов железа, мицелл. До сих пор не выдано ни одного регистрационного удостоверения на наночастицы селена. Одна из причин такого положения в данной области, с нашей точки зрения, заключается в том, что механизмы взаимодействия наночастиц с клетками изучены недостаточно. Отсутствие фундаментальных исследований в данной области является одним из основных препятствий при разработке лекарственных препаратов нового поколения на основе наночастиц.

Текст

Текст. Данный обзор посвящен анализу научной литературы по исследованию взаимодействия наночастиц селена с разными видами клеток. В статье рассматриваются биологические свойства селена и его роль в метаболизме клеток. Приводятся данные о цитотоксическом действии наночастиц селена на различные клеточные культуры. Описаны методы получения наночастиц и методы исследования взаимодействия наночастиц с клеточными культурами.

Заключение

Заключение. Анализ литературных данных позволяет сделать выводы об актуальности исследований взаимодействия наночастиц селена с живыми клетками. Это необходимо для определения механизмов поглощения наночастиц селена, изучения их цитотоксического и/или цитостатического действия, распределения в клетках. Исследования биологического взаимодействия наночастиц селена c опухолевыми и нормальными клетками позволит определить наиболее информативные методы регистрации и количественной оценки их противоопухолевой активности, что актуально при разработке новых лекарственных средств против рака.

Introduction

Introduction. The prospects of using nanoparticles in the production of medicines are widely discussed in the literature. In 2018 alone, the quantity of registration certificates issued by national regulators for medicines that use nanoparticles in one form or another is around forty. Most of them are medicines based on liposomes, polymers, iron oxides, micelles. So far, no registration certificates have been issued for selenium nanoparticles. One of the reasons for this situation in this area, from our point of view, is that the mechanisms of interaction of nanoparticles with cells are not sufficiently studied. The lack of basic research in this area is one of the main obstacles to the development of new-generation drugs based on nanoparticles.

Text

Text. This review is devoted to the analysis of scientific data on the interaction of selenium nanoparticles with different types of cells. The article discusses the biological properties of selenium and its role in cell metabolism. Data on the cytotoxic effect of selenium nanoparticles on various cell cultures are presented. Methods of preparation of nanoparticles and methods for studying the interaction of nanoparticles with cell cultures are described.

Conclusion

Conclusion. Analysis of the literature data allows us to draw conclusions about the relevance of research on the interaction of selenium nanoparticles with living cells. This is necessary to determine the mechanisms of selenium nanoparticles absorption, study their cytotoxic and / or cytostatic action, and distribution in cells. Investigation of the biological interaction of selenium nanoparticles with tumor and normal cells will determine the most informative methods for registering and quantifying their antitumor activity, which is relevant for the development of new drugs to treat cancer.

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The authors declare that there are no conflicts of interest present.