pharmjournalРазработка и регистрация лекарственных средствDrug development & registration2305-20662658-5049LLC «CPHA»pharmjournal-903Research ArticleПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИPRACTICAL RECOMMENDATIONSВозможности низкопольных спектрометров ЯМР в скрининге содержания лекарственных субстанцийPossibilities of low-field NMR spectrometers in screening the content of medicinal substancesКалабинГ. А.KalabinG. A.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

ВасильевВ. Г.Vasil’evV. G.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

ИвлевВ. А.IvlevV. A.

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6, Mikluho-Maklaya str., Moscow, 117198

ФГАОУ ВО «Российский университет дружбы народов» (Российский университет дружбы народов, РУДН)Peoples Friendship University of Russia (RUDN University)2021030320211011622Copyright © Калабин Г.А., Васильев В.Г., Ивлев В.А., 20212021Калабин Г.А., Васильев В.Г., Ивлев В.А.Kalabin G.A., Vasil’ev V.G., Ivlev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmjournal.ru/jour/article/view/903

Предложено применение современных низкопольных спектрометров ЯМР ¹Н на рабочей частоте 60 МГц для контроля подлинности лекарственных средств. Проведена апробация фурье-спектрометра ЯМР Pulsar компании Oxford Instruments (Великобритания) в качестве инструмента для идентификации и количественного анализа ряда лекарственных средств (ЛС). Показано, что спектры ЯМР ¹Н на рабочей частоте 60 МГц позволяют идентифицировать в ЛС лекарственные субстанции, а по выделенным обособленным индикаторным сигналам определять их количественное содержание без использования стандартных образцов. Для валидации и верификации разрабатываемых методик бесстандартного скрининга рекомендовано использование тандема низкопольной и высокопольной (более 300 МГц для ¹Н) аппаратуры ЯМР.

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The authors declare that there are no conflicts of interest present.