SUPPOSITORIES: ASPECTS OF DOSAGE FORM MODERNIZATION
Abstract
In this material were reviewed biopharmaceutical aspects of suppositories – described the relation between rectal route of administration, bioaccessibility and principles of dosage forms formulation. Also, in the article were shown the physical and chemical characteristics of API, matrix and excipients (surface-active agents, prolongation agents, cyclodextrines, etc.). Was presented information about mucoadhesive suppositories, suppositories with different types of release methods (immediate intensive or prolonged) and poloxamer-based thermo-reversible liquid suppositories (characteristics, pharmaceutical, technological and biopharmaceutical parameters of quality).
About the Authors
N. B. Diomina
I.M.Sechenov First Moskow State Medical University
Russian Federation
Russian Federation
M. N. Anurova
I.M.Sechenov First Moskow State Medical University
Russian Federation
Russian Federation
References
1. Т.В. Орлова, Т.А. Панкрушева. Вспомогательные вещества в технологии суппозиториев и научно-методические подходы к их выбору. - Курск.: Изд-во КГМУ, 2013. 160 с.
2. Н.Б. Демина. Современные аспекты производства лекарственной формы суппозитории // Разработка и регистрация лекарственных средств. 2016. № 1 (12). С. 22-31.
3. J.H. Rytting, J.A. Fix. Drug Delivery: Rectal Route // Encyclopedia of Pharmaceutical Technology. 3rd ed. / Ed. by James Swarbrick. - New York, London: PharmaceuTech, Inc. 2007, P. 1298-1311.
4. Т.В. Орлова. Исследование суппозиториев по тесту «Растворение» // Тест «Растворение» в разработке и регистрации лекарственных средств. - М.: Перо, 2015. С. 185-219.
5. MedicalPlanet. URL: http://medicalplanet.su/farmacia/637.html (дата обращения 15.03.2016).
6. T. Phaechamud, W. Muennoom. Effect of Xanthan Gum and HPMC on Drug Liberation from Hollow-type Fast and Sustained Release Suppositories // Research Journal of Pharmaceutical. Biological and Chemical Sciences. 2015. № 4. P. 1034-1044.
7. А. Yousfan, J. Hasian. Preparation and evaluation of Levodropropizine suppositories // Journal of Chemical and Pharmaceutical Research. 2015. № 7(7). P. 274-282.
8. R.V. Keneny, C.J. Lourenco. Formulation and evaluation of thermo-reversible in situ gelling and mucoadhesive Diltiazem hydrochloride liquid suppository // International Journal of Pharma and Bio Sciences. 2010. № l(l). P. 17.
9. Е.А. Киржанова, В.В. Хуторянский, Н.Г. Балабушевич, А.В. Харенко, Н.Б. Демина. Методы анализа мукоадгезии: от фундаментальных исследований к практическому применению в разработке лекарственных форм // Разработка и регистрация лекарственных средств. 2014. № 3(8). С. 66-82.
10. Е.А. Харенко, Н.И. Ларионова, Н.Б. Демина. Мукоадгезивные лекарственные формы (обзор) // Химико-фармацевтический журнал. 2009. № 4 (43). С. 21-29.
11. R. Yahagi, Y. Machida, H. Onishi, Y. Machida. Mucoadhesive suppositories of ramosetron hydrochloride utilizing Carbopol® // Int. Journal of Pharmaceutics. 2000. № 193. P. 205-212.
12. G. Eman, M. Mokhtar, H. El Ghamry, F. Ghazy. Sustained Release Rectal Suppositories as Drug Delivery Systems for Atenolol // Journal of American Science. 2012. № 8(12). P. 323-332.
13. M. Mokhtar, O.A. Sammour, M.A. Hammad, N.A. Megrab. Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes // Int. J. Pharm. 2008. №361(1-2). P. 104-111.
14. B. Vora, A.J. Khopade, N.K. Jain. Proniosome based transdermal delivery of levonorgestrel for effective contraception // J. Controlled Release. 1998. № 54. P. 149-165.
15. European Pharmacopoeia. 8th ed. Suppl. 8.0. - Strasburg: Europian Department for the Quality of Medicines. 2015. V. 1.
16. The United States Pharmacopeia - National Formulary. USP 38. Rockville, MD: The United States Pharmacopoeial Convention, 2015.
17. Государственная фармакопея Российской Федерации. XIII изд. Т. 2. - М. 2015.
18. D. Ramya Devi, P. Sandhya, B.N. Vedha Hari. Poloxamer: A Novel Functional Molecule For Drug Delivery And Gene Therapy // J. Pharm. Sci. & Res. 2013. № 5(8) P. 159-165.
19. E.V. Bartrakova, A.V. Kabanov. Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers // J. Control. Release. 2008. № 2(130). P. 98-106.
20. Yu-Li Lo, Yijun Lin, Hong-Ru Lin. Evaluation of Epirubicin in Thermogelling and Bioadhesive Liquid and Solid Suppository Formulations for Rectal Administration // Int. J. Molecular Sciences. 2014. № 1. P. 342-360.
21. Y.J. Park, C.S. Yong, H.M. Kim, J.D. Rhee, Y.K. Oh, C.K. Kim. Effect of sodium chloride on the release, absorption, and safety of diclofenac sodium delivered by poloxamer gel // Int. J. Pharm. 2003. № 263. P. 105-111.
22. A.A. Koffi, F. Agnely, M. Besnard, K. Brou, J.L. Grossiord, G. Ponchel. In vitro and in vivo characteristics of a thermogel-ling and bioadhesive delivery system intended for rectal administration of quinine in children // Eur. J. Pharm. Biopharm. 2008. № 69. P. 167-175.
23. А. Yousfan, J. Hasian. Preparation and evaluation of Levodropropizine suppositories // Journal of Chemical and Pharmaceutical Research. 2015. № 7 (7). P. 274-282.
24. H.G. Choi, J.H. Hung, J.M. Ryu, S.J. Yoon, Y.K. Oh, C.K. Kim. Development of in-situ gelling and mucoadhesive acetaminophen liquid suppository // Int. J. Pharm. 1998. № 165. P. 33-44.
25. H.G. Choi, Y.K. Oh, C.K. Kim. In-situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability // Int. J. Pharm. 1998. № 165. P. 23-32.
26. S.S. Pisal, A.R. Paradkar, K.R. Mahadik, S.S. Kadam. Pluronic gels for nasal delivery of vitamin B12. Part I: Preformulation study // Int. J. Pharm. 2004. № 270. P. 37-45.
27. A.S.M. Abu El-Enin, G.S. El-Feky. Formulation and Evaluation of In-situ Gelling Tenoxicam Liquid Suppositories // J. of Life Medicine. 2013. № 1(2). P. 23-32.
28. А. El-Kamel, M. El-Khatib. Thermally Reversible In Situ Gelling Carbamazepine Liquid Suppository // Drug Delivery. 2006. № 13. P. 143-148.
29. Jin-Ki Kim, Myung-Sun Kim, Jeong-Sook Park, Chong-Kook Kim. Thermo-reversible flurbiprofen liquid suppository with HP-β-CD as a solubility enhancer: improvement of rectal bioavailability // J. of Inclusion Phenomena and Macrocyclic Chemistry. 2009. № 64(3). P. 265-272.
Review
For citations:
Diomina N.B., Anurova M.N. SUPPOSITORIES: ASPECTS OF DOSAGE FORM MODERNIZATION. Drug development & registration. 2016;(4):92-97. (In Russ.)
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