DEVELOPMENT OF METHOD FOR DETERMINING THE THERMODYNAMIC AND KINETIC PARAMETERS OF DECOMPOSITION SUBSTANCES IN THE FORM OF THE POWDER MIXTURE WITH HIGHLY THERMALLY CONDUCTIVE INERT MATERIAL BY DIFFERENTIAL SCANNING CALORIMETRY ON THE EXAMPLE OF PARACETAMOL AND CHLORAMPHENICOL
Abstract
Development of method for determining the melting enthalpy of monotropic transitions and the activation energy of substances decomposition using highly thermally conductive inert material by differential scanning calorimetry and its practical use for determining the weight content of the active substance in solid medicinal substance.
About the Authors
A. V. Ponomareva
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
A. V. Dudkin
Lipetsk State Technical University
Russian Federation
Russian Federation
References
1. А. П. Арзамасцев. Применение дифференциальной сканирующей калориметрии в анализе лекарственных веществ // Фармация. 1982. № 1. С. 36-40.
2. В. Хеммингер, Г. Хене. Химия - Калориметрия. Теория и практика / Пер. с англ. О.Б Саламатиной. - М., 1989. C. 176.
3. Я. Шестак. Теория термического анализа. Физико-химические свойства неорганических веществ / Пер. с англ. - М.: Мир, 1987. C. 456.
4. M. E. Brown. Introduction to Thermal Analysis. Techniques and Applications. Second Edition. - Dordrecht: Kluer Academic Publishers. 2001. P. 116-126.
5. E. Marti, E. Kaisersberger, G. Kaiser, W.-Y. Ma. Thermoanalytical Characterization of Pharmaceuticals // Netzsch Annual. 2000. P. 110.
6. K. C. Thompson. Pharmaceutical applications of calorimetric measurements in the new millennium // Thermochimica Acta. 2000. V. 355. P. 83-87.
Review
For citations:
Ponomareva A.V., Dudkin A.V. DEVELOPMENT OF METHOD FOR DETERMINING THE THERMODYNAMIC AND KINETIC PARAMETERS OF DECOMPOSITION SUBSTANCES IN THE FORM OF THE POWDER MIXTURE WITH HIGHLY THERMALLY CONDUCTIVE INERT MATERIAL BY DIFFERENTIAL SCANNING CALORIMETRY ON THE EXAMPLE OF PARACETAMOL AND CHLORAMPHENICOL. Drug development & registration. 2016;(4):168-172. (In Russ.)
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