Производные 2-амино-4-(2-фурил)пиридин-3-карбонитрилов как перспективные антистафилококковые препараты

Введение. Соединения, содержащие в своем составе фурановый фрагмент, часто проявляют антимикробную активность. Несмотря на то что среди производных пиридина нет препаратов, проявляющих противомикробную активность, его комбинация с фурановым заместителем может рассматриваться как перспективный тандем для создания эффективных антимикробных препаратов.

Цель. Целью данного исследования является синтез гибридных структур, содержащих фурановый и аминопиридиновый фрагменты и исследование их антимикробных свойств.

Материалы и методы. Реакцией фурфурола, малонодинитрила, ацетата аммония и соответствующего кетона получена серия 5,6-замещенных 2-амино-4-(2-фурил)-пиридин-3-карбонитрилов.

Результаты и обсуждение. Для полученных соединений исследована их антимикробная активность в отношении бактерий Staphylococcus aureus, Pseudomonas aeruginosa и дрожжеподобных грибов Candida utilis. Определены соединения, обладающие высокой антибактериальной активностью, проведена оценка влияния заместителей в 5 и 6 положениях на исследуемую активность.

Заключение. Получен ряд новых замещенных 5,6-диалкил-4-фурил-2-аминопиридинил-3-карбонитрилов и исследована in vitro их антимикробная активность.

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