Determination of steroid compounds and triterpene glycosides in marine echinoderm extracts by HPLC-MS/MS using the LicArt 62 chromatograph as a front-end system
Abstract
Polar steroid compounds from starfish and triterpene glycosides from sea cucumbers represent unique classes of biologically active secondary metabolites characterized by considerable structural diversity and a broad range of biological effects. A metabolomics approach based on HPLC-MS/MS was applied to investigate complex mixtures of these natural compounds. Chromatographic separation was performed using a LicArt 62 HPLC coupled to a Bruker Impact II Q-TOF quadrupole time-of-flight mass spectrometer. More than 350 compounds were detected in the Lethasterias fusca starfish extract and more than 550 compounds were detected in the Eupentacta fraudatrix sea cucumber extract.
Supporting agencies: The authors prepared the article with the financial support of the Labconcept LLC. The study described below was conducted at the laboratory of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC).
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Determination of steroid compounds and triterpene glycosides in marine echinoderm extracts by HPLC-MS/MS using the LicArt 62 chromatograph as a front-end system. Drug development & registration. 2026;15(3):17-21. (In Russ.)
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