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Разработка и регистрация лекарственных средств

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ДАУНСТРИМ-ПРОЦЕСС ОЧИСТКИ БИОФАРМАЦЕВТИЧЕСКИХ БЕЛКОВ

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Аннотация

Развитие биофармацевтической отрасли начинается с разработки эффективных продуцентов. Однако чем сложнее белок и его продуцент, тем большее количество примесей, среди которых эндотоксины, белки хозяина, вирусы, родственные примеси, агрегаты и высокомолекулярные контамитанты, синтезируется или накапливается в ходе процесса получения. Статья описывает под ходы к выделению и очистке биофармацевтических белков (даунстрим-процесс). Обсуждаются основные хроматографические и нехроматографические методы.

Об авторе

Д. А. Гусаров
Научно-производственная биотехнологическая платформа «ЭкспертБИОТЕ»
Россия


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Для цитирования:


Гусаров Д.А. ДАУНСТРИМ-ПРОЦЕСС ОЧИСТКИ БИОФАРМАЦЕВТИЧЕСКИХ БЕЛКОВ. Разработка и регистрация лекарственных средств. 2016;(3):88-99.

For citation:


Gusarov D.A. DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS. Drug development & registration. 2016;(3):88-99. (In Russ.)

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