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REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS

Abstract

Release profiles were investigated from tablets of ibuprofen in media simulating the conditions of the gastrointestinal tract. Carbopol Ultrez 21 was used as prolongator polymer. The formulations with three different neutralizing agents [L-lysine, N-methylglucosamine (MGA), sodium hydrocarbonate] in several carbopol : neutralizer ratios were tabletted with using the wet granulation method. Faster release of ibuprofen has been observed in formulations with sodium hydrocarbonate, than in formulations with amine containing L-lysine and MGA. Both the amount and neutralization rate of carbopol influence significantly on rate and extent of ibuprofen release from tablets. Carbopol swelling rate grows up with increasing of neutralizer content in tablet.

About the Authors

N. I. Filippova
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation


V. A. Vainshtein
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation


A. V. Son
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation


S. A. Minina
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation


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Review

For citations:


Filippova N.I., Vainshtein V.A., Son A.V., Minina S.A. REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS. Drug development & registration. 2017;(1):58-64. (In Russ.)

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ISSN 2305-2066 (Print)
ISSN 2658-5049 (Online)