METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
Abstract
The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmaceuticals (low solubility and chemical stability of such drug) and the advantages of liposomes to deliver them are reported. It is established that the most promising technology of producing liposomes containing drugs with antioxidant effects is a thin film hydration method with further sonication.
About the Authors
A. A. Novikova
Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)
Russian Federation
Russian Federation
P. Kezimana
Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)
Russian Federation
Russian Federation
Ya. M. Stanishevskiy
Peoples' Friendship University of Russia (RUDN University) (Institute of Biochemical Technology and Nanotechnology)
Russian Federation
Russian Federation
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Review
For citations:
Novikova A.A., Kezimana P., Stanishevskiy Ya.M. METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW). Drug development & registration. 2017;(2):134-138. (In Russ.)
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