SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN
Abstract
Methods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by determining prothrombin time (PT). The most pronounced activity was possessed by substances AZ-5 (conjugate warfarin with a fragment of the substance diumancal, 41,2±2,3 s) and AZ-9 (diumancal, 45,18±4,85 s), comparable with the reference drug warfarin (37,4±2,8 s).
About the Authors
A. Z. Abyshev
Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
I. K. Zhurkovich
Institute of Toxicology FMBA
Russian Federation
Russian Federation
D. Yu. Ivkin
Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
C. B. Nguyen
Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
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Review
For citations:
Abyshev A.Z., Zhurkovich I.K., Ivkin D.Yu., Nguyen C.B. SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN. Drug development & registration. 2017;(2):192-198. (In Russ.)
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