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DETERMINATION OF STRUCTURAL-MECHANICAL PROPERTIES OF SOFT DRUGS

Abstract

The possibility of determining the structural and mechanical properties of ointment and creamy bases, such as the yield point, speed and degree of stress relaxation and thixotropic structure restoration, is described. The proposed method consists in measuring the mechanical stress that occurs when the tester is immersed in a consistency mass. The dependence of the mechanical stress measured in the process of relaxation on the logarithm of time is linear, which makes it simple and convenient to determine the structural and mechanical properties of the test samples.

About the Author

V. A. Vainshtein
Saint-Petersburg state chemical and pharmaceutical academy, Ministry of Healthcare
Russian Federation


References

1. ОФС.1.2.1.0015.15. Вязкость // Государственная фармакопея, XIII изд. URL: http://pharmacopoeia.ru/ofs-1-2-1-0015-15-vyazkost/ (дата обращения 10.07.2017).

2. Лекция № 6.1. Механика биологических жидкостей. URL: http://te.zavantag.com/docs/1396/index-24789.html (дата обращения 10.07.2017).

3. М.В. Дунаева. Исследование пенетрации при разработке лекарственных форм // Разработка и регистрация лекарственных средств. 2017. №1(18). С. 285.


Review

For citations:


Vainshtein V.A. DETERMINATION OF STRUCTURAL-MECHANICAL PROPERTIES OF SOFT DRUGS. Drug development & registration. 2017;(3):70-78. (In Russ.)

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ISSN 2305-2066 (Print)
ISSN 2658-5049 (Online)