DEVELOPMENT OF TECHNOLOGICAL PROCESSES OF THE DRY EXTRACTS OF MORINDA CITRIFOLIA ROOTS
Abstract
The aim of this study is to develop the technology of dry extracts from the roots of Morinda citrifolia as a prospective phyto-active pharmaceutical ingredient (API) for obtaining medicinal products. Factors influencing the extraction process of active ingredients from the roots of Morinda citrifolia were investigated. The modes of extraction were formulated: extraction time of 60 minutes, the hydro-module was established to be 1:30, the extractant - 70% ethyl alcohol. The study developed a technological process of obtaining dry extracts.The technological scheme of production of dry extracts was proffered. The parameters of standardization of the dry extract of Morinda citrifolia roots were established.
About the Authors
R. K. Agbadi
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Russian Federation
I. E. Kaukhova
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Russian Federation
V. A. Vanshtein
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Russian Federation
S. A. Minina
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Russian Federation
M. V. Yakovleva
Federal State Bulgetary Institute «А.М. Nikiforov Russian Centre of Emergency and Radiation Medicine» of the Ministry for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters of Russian Federation
Russian Federation
Russian Federation
M. A. Vlasenko
Federal State Bulgetary Institute «А.М. Nikiforov Russian Centre of Emergency and Radiation Medicine» of the Ministry for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters of Russian Federation
Russian Federation
Russian Federation
A. Y. Kutlushina
Saint-Petersburg State Chemical-Pharmaceutical Academy
Russian Federation
Russian Federation
References
1. K. Duduku, N. Rajesh, S. Rosalam. Phytochemical Constituents and Activities of Morinda citrifolia L. // Agricultural and Biological Sciences. 2012. P. 141-144.
2. D.R. Singh. Morinda citrifolia L. (Noni): A review of the scientific validation for its nutritional and therapeutic properties // Journal of Diabetes and Endocrinology. 2012. V. 3(6). Р. 78-85.
3. A. Abbott. The geographic origin of the plants most commonly used for medicine by Hawaiians // J. Ethnopharmacol. 1985. V. 14. P. 213-222.
4. Vietnamese Pharmacopoeia Commission. 4rd ed. 2010.
5. I.E. Kaukhova, R.K. Agbadi, S.K. Minina, A.U. Kutlushina. Roots, herbs and fruits of Morinda citrifolia as perspective drug substance in the technology of phytopreparations // Фармация. 2017. Т. 66. № 4. С. 25-27.
6. Л.Г. Подунова и др. Методика определения микроэлементов в диагностируемых биосубстратах атомной спектрометрией с индуктивно связанной аргоновой плазмой. Методические рекомендации (утв. ФЦ ГСЭН 29.01.2003). - М.: ФЦГСЭН МЗ РФ, 2003. 50 c.
7. Государственная фармакопея Российской Федерации. XIII изд. - М. 2015. URL: http://www.femb.ru/feml (дата обращения).
Review
For citations:
Agbadi R.K., Kaukhova I.E., Vanshtein V.A., Minina S.A., Yakovleva M.V., Vlasenko M.A., Kutlushina A.Y. DEVELOPMENT OF TECHNOLOGICAL PROCESSES OF THE DRY EXTRACTS OF MORINDA CITRIFOLIA ROOTS. Drug development & registration. 2017;(3):94-97. (In Russ.)
Views:
794
Email this article 