MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE
Abstract
The process of desorption of vinpocetine on the surface of crystalline silicon and silicon oxide in various media has been studied by molecular dynamics modeling. The desorption of vinpocetine in water has been established both from the surface of silicon and from the surface of silicon oxide. The character of the desorption of vinpocetine from silicon and silicon oxide at pH 6.8 and pH 7 differs insignificantly (within the error of the simulation results). The desorption of vinpocetine in acidic medium (pH 2) from silicon and silicon oxide occurs more efficiently and at a higher rate, compared to pH 6.8 and pH 7.
About the Authors
Yu. A. Polkovnikova
Voronezh State University
Russian Federation
Russian Federation
A. S. Lenshin
Voronezh State University
Russian Federation
Russian Federation
A. A. Glushko
Pyatigorsk Medical Pharmaceutical Institute of Volgograd Medical State University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
O. M. Khishova
Vitebsk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Polkovnikova Yu.A., Lenshin A.S., Glushko A.A., Khishova O.M. MODELING AND ANALYSIS OF MOLECULAR DYNAMICS OF SILICON-SOLVENT-VINPOCETIN SYSTEMS AND SILICON-SOLVENT-VINPOCETIN DIOXIDE. Drug development & registration. 2017;(4):44-49. (In Russ.)
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