DEVELOPMENT OF TECHNOLOGY AND METHODS OF CONTROL OF BIFUNCTIONAL OINTMENT
Abstract
A new bifunctional ointment with chondroitin sulfate and celecoxib on a hydrophilic base was developed. The optimum conditions of the technology and technological properties of the ointment were determined. The techniques for quantitativecontrol of active components in a bifunctional ointment are developed. Quantitative determination of chondroitin sulfate in an ointment was conducted by turbidimetric titration. A relative error of determination with confidence probability P=95% is not more than 2,01%. Quantitative determination of celecoxib was conducted by spectrophotometry. A relative error of determination with confidence probability P=95% is not more than 3,22%.
About the Authors
K. R. Saveleva
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
T. Y. Andreevicheva
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
L. V. Persanova
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
O. A. Ostapyuk
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
S. V. Polyakov
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
V. N. Shestakov
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
References
1. А.Л. Барсук. Современные аспекты фармакотерапии остеоартроза: хондропротекторы для местного и перорального применения // РМЖ. Независимое издание для практикующих врачей. URL: http://www.rmj.ru/articles_8686.htm (дата обращения 16.10.2017).
2. О.М. Фоломеева, Ш.Ф. Эрдес. Распространенность и социальная значимость ревматических заболеваний в Российской Федерации // Энциклопедия лекарств и товаров аптечного ассортимента. URL: http://www.rlsnet.ru/articles_461.htm (дата обращения 16.10.2017).
3. Е.А. Долгова, Д.Р. Ракита. Фармакоэпидемиология остеоартрита в Рязанской области // Современные проблемы науки и образования. 2012. № 6. URL: www.science-education.ru/106-7403 (дата обращения 16.10.2017).
4. Н.Н. Крюков и др. Справочник терапевта. - Ростов-на-Дону: Феникс, 2013. 446 с.
5. Л.И. Алексеева. Современные представления о диагностике и лечении остеоартроза // Русский медицинский журнал. 2000. № 8-9. С. 377-379.
6. Патент РФ № 2582974. Комбинированная активная композиция для лечения заболеваний опорно - двигательной системы / В.Н. Шестаков, Т.Ю Андреевичева, Л.В. Персанова, К.Р. Савельева. - Бюл. № 12. 2016.
Review
For citations:
Saveleva K.R., Andreevicheva T.Y., Persanova L.V., Ostapyuk O.A., Polyakov S.V., Shestakov V.N. DEVELOPMENT OF TECHNOLOGY AND METHODS OF CONTROL OF BIFUNCTIONAL OINTMENT. Drug development & registration. 2017;(4):50-54. (In Russ.)
Views:
678
Email this article 