DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE
Abstract
The article presents data on the development of a technique for determination of intrinsic viscosity of injectable drug with chondroitin sodium sulfate. A 0.2 M solution of sodium chloride was use as a solvent to eliminate polyelectrolyte swelling. The calculated viscosity of the test solutions was determinate in the concentration range of chondroitin sulfate 4.5-20 mg /ml. The value of the intrinsic viscosity, determined for each of the tested preparations, was in the range 0.03-0.042 m3/kg.
About the Authors
K. R. Saveleva
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
L. V. Pesanova
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
V. N. Shestakov
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
S. V. Poliyakov
State Institute of Drugs and Good Practices of the Ministry of Industry and Trade of Russian Federation
Russian Federation
Russian Federation
References
1. Е.С. Северин. Биохимия: Учебник / Под ред Е.С. Северина. - М.: ГЭОТАР-Медиа, 2003. 779 с.
2. Европейская Фармакопея 8.0. URL: http://www.fptl.ru/biblioteka/farmakopei/evropeyskaya-farmakopeya_8_vol-2.pdf (дата обращения 10.10.2017).
3. Т.Н. Шкарина. Анализ и стандартизация хондроитина сульфата натрия: автореф. дис.. к.фарм.н. - М.: НЦЭСМП, 2009.
4. Патент РФ 2612014. Средство для лечения артрологических заболеваний / В.Н. Шестаков, Л.В. Персанова, К.Р. Савельева, Т.Ю. Андреевичева. - Бюл. № 7, 2017.
5. О.В. Борисов, Е.Б. Жулина, А.А. Полоцкий, А.А Даринский, И.М. Неелов. Основы физики макромолекул: Учебное пособие. - СПб: Университет ИТМО, 2015. 74 с.
6. А.Д Антипина. Методические разработки к практическим работам по полиэлектролитам: Учебное пособие. - М.: МГ У им. М.В. Ломоносова, 1988. - 56.
7. ОФС.1.2.1.0015.15. Вязкость // Государственная фармакопея РФ. XIII изд.
Review
For citations:
Saveleva K.R., Pesanova L.V., Shestakov V.N., Poliyakov S.V. DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE. Drug development & registration. 2017;(4):154-158. (In Russ.)
Views:
1005
Email this article 