THE MODERN METHODS OF ANALYSIS OF OXIDIZED AND REDUCED FORMS OF COENZYME Q₁₀ IN BIOMATERIAL (REVIEW)
Abstract
In the human body, coenzyme Q10 is in the oxidized and reduced forms and can be found in every organ. The review describes modern HPLC methods of coenzyme Q10 analysis using electrochemical, spectrophotometric and mass spectrometric detectors. In the article we present information on sampling, preparation of biomaterial for analysis and preservation of coenzyme Q10 stability in biomaterial. It is carried out a comparative analysis of the determination methodologies for the oxidized and reduced forms of coenzyme Q10 by its sensitivity and selectivity.
About the Authors
V. I. Zozina
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
O. A. Goroshko
Scientific Centre for Expert Evaluation of Medical Products of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
L. M. Krasnykh
Scientific Centre for Expert Evaluation of Medical Products of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
V. G. Kukes
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation;
Scientific Centre for Expert Evaluation of Medical Products of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Zozina V.I., Goroshko O.A., Krasnykh L.M., Kukes V.G. THE MODERN METHODS OF ANALYSIS OF OXIDIZED AND REDUCED FORMS OF COENZYME Q₁₀ IN BIOMATERIAL (REVIEW). Drug development & registration. 2018;(1):84-88. (In Russ.)
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