STABILITY OF DRUG FORM OF PARACETAMOL, FORMED ON THE BASIS OF CRYSTALS OF ROMBIC MODIFICATION
Abstract
Drug form of paracetamol formed on the basis of molecular crystals of rhombic modification was studied. The studies included technological experiments, optical microscopy, differential scanning calorimetry, X-ray diffraction and IR spectroscopy. It is found that drug forms of paracetamol, synthesized by calorimetric method, together with enlarged solubility possess remarkable sensibility to temperature and mechanic grinding. It is presented X-ray patterns, IR spectra and curves of differential scanning calorimetry.
About the Authors
A. P. Belyaev
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
V. P. Rubets
Saint-Petersburg State Institute of Technology (Technical University)
Russian Federation
Russian Federation
V. V. Antipov
Saint-Petersburg State Institute of Technology (Technical University)
Russian Federation
Russian Federation
E. Y. Rodionova
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
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Review
For citations:
Belyaev A.P., Rubets V.P., Antipov V.V., Rodionova E.Y. STABILITY OF DRUG FORM OF PARACETAMOL, FORMED ON THE BASIS OF CRYSTALS OF ROMBIC MODIFICATION. Drug development & registration. 2018;(1):162-164. (In Russ.)
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