NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY
Abstract
The method of obtaining new heterocyclic compounds - chlorides 2-[(Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-iliden)methyl]-3,5-diaryl-1,3,4-thiadiazol-3 was developed. The structure and individuality of the obtained compounds are proved by the physico-chemical methods for the identification of organic compounds: 1Н and 13С NMR, IR spectrometry, mass spectrometry. Antibacterial activity was defined against Escherihia coli, Staphylococcus aureus, Bacillus cereus. It was shown that these compounds have a pronounced antibacterial activity against gram-positive bacteria. The most active compound has been identified, which can potentially be used in medicine as an antimicrobial agent.
About the Authors
A. S. Koshevenko
Saint-Petersburg State Chemical and Pharmaceutical University of the Russian Federation Ministry of Healthcare
Russian Federation
Russian Federation
V. N. Yuskovets
Saint-Petersburg State Chemical and Pharmaceutical University of the Russian Federation Ministry of Healthcare
Russian Federation
Russian Federation
E. P. Ananyeva
Saint-Petersburg State Chemical and Pharmaceutical University of the Russian Federation Ministry of Healthcare
Russian Federation
Russian Federation
I. P. Yakovlev
Saint-Petersburg State Chemical and Pharmaceutical University of the Russian Federation Ministry of Healthcare
Russian Federation
Russian Federation
T. L. Semakova
Saint-Petersburg State Chemical and Pharmaceutical University of the Russian Federation Ministry of Healthcare
Russian Federation
Russian Federation
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Review
For citations:
Koshevenko A.S., Yuskovets V.N., Ananyeva E.P., Yakovlev I.P., Semakova T.L. NEW 1,3,4-TIADIAZOLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY. Drug development & registration. 2018;(2):96-98. (In Russ.)
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