THE USE OF NAFTIFINI HYDROCHLORIDE AND ITS ADVANTAGES IN THE TREATMENT OF VARIOUS TYPERS OF FUNGAL DISEASES
Abstract
Studying the susceptibility of dermatophyte strains to naftifine revealed that the range of inhibitory concentrations (MIC) is 0,1-0,2 μg/ml. The naftifine spectrum is very wide and includes almost all mycotic pathogens. Testing the strains of Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum in comparison with clotrimazole and 4-imidazole antimycotics has shown that naftifine is the most active drug affecting dermatophytes. In concentrations of no more than 1,0 μg/ml, naftifine inhibited 98,75% of dermatophyte strains. Naftifine hydrochloride can find a worthy use in the treatment of skin diseases against the background of infectious and inflammatory processes associated with mycoses.
About the Authors
S. I. Kosenkova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
I. I. Krasnyuk
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
I. I. Krasnyuk (Jr.)
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kosenkova S.I., Krasnyuk I.I., Krasnyuk (Jr.) I.I. THE USE OF NAFTIFINI HYDROCHLORIDE AND ITS ADVANTAGES IN THE TREATMENT OF VARIOUS TYPERS OF FUNGAL DISEASES. Drug development & registration. 2018;(2):144-148. (In Russ.)
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