EMBININ IS A PERSPECTIVE CARDIOTONIC MEAN FOR NATURAL ORIGIN
Abstract
Embinin is a flavone C-glycoside from the aerial part of the milky white tangent (Iris lactea). Cardiotonic action was established earlier for the extract of Iris lactea. Identification of the active substance responsible for this type of biological activity seems to be an urgent task. The purpose of this study was to evaluate the cardiotropic effect and the toxicological profile of embinin. The acute toxicity of embinin was determined in accordance with GOST 32644-2014, the inotropic effect of embinin was evaluated in comparison with digoxin in the model of perfusion of the isolated rat heart by Langendorf, and also in vivo by echocardiographic study with calculation of the left ventricular shortening fraction and electrocardiogram analysis. The embinin in a dose of 2000 mg/kg didn’t cause the death of female rats. The substance has a pronounced inotropic effect. Establishment of a pronounced cardiotonic effect in the experiment and low toxicity, as well as a high probability of the presence of cardioprotective action of embinin, predicted using the PASS program, allow us to consider embinin as a promising molecule for further studies in cardiovascular disease.
About the Authors
D. Yu. Ivkin
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
V. G. Luzhanin
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
A. A. Karpov
Academician I. P. Pavlov First St. Petersburg State Medical University;
National Medical Research Center
Russian Federation
Russian Federation
S. M. Minasyan
Academician I. P. Pavlov First St. Petersburg State Medical University;
National Medical Research Center
Russian Federation
Russian Federation
Ya. I. Poleshchenko
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
A. E. Mamedov
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
M. N. Povydysh
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
V. V. Poroykov
Institute of Biomedical Chemistry
Russian Federation
Russian Federation
I. A. Narkevich
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
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Review
For citations:
Ivkin D.Yu., Luzhanin V.G., Karpov A.A., Minasyan S.M., Poleshchenko Ya.I., Mamedov A.E., Povydysh M.N., Poroykov V.V., Narkevich I.A. EMBININ IS A PERSPECTIVE CARDIOTONIC MEAN FOR NATURAL ORIGIN. Drug development & registration. 2018;(3):166-170. (In Russ.)
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