PLANTS OF GENERA GENISTA L. AS PROMISING SOURCES OF PLANT RAW MATERIALS FOR THE CREATION OF NEW DRUG
Abstract
The review presents the geographical distribution, botanical description, chemical composition, information about the use in medicine and the study of the pharmacological activity of the representatives of the genus Genista L. It is shown that the plants of the genus are widely distributed on the territory of the Russian Federation, however, it is rather difficult to systematize the plants of the genus of interest on the basis of morphological characters, since they have an extensive habitat and, accordingly, the morphological characteristics of one species vary greatly within the range. Plants of the genus have a rich composition of biologically active substances. At the same time, an analysis of literature data on products of the secondary metabolism of species of the genus Genista revealed an uneven degree of their knowledge. Infusions and decoctions from the grass of Genista are used in folk medicine as a diuretic, choleretic and laxative, and an analysis of literary sources showed that plants of the genus are promising in various pathologies. The authors of the review showed the need for a complex morphological, anatomical, phytochemical, and molecular genetic study of plants of the genus Genista to clarify the taxonomy and introduction into medical practice.
About the Authors
E. V. Zhokhova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Y. A. Protasova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
G. P. Yakovlev
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
References
1. Alieva S. A. Flavonoids Genista transcaucasica // Chemistry of natural compounds. 1974. № 1. Р. 113-114.
2. Goncharov M. Yu., Povydysh M. N., Yakovlev G. P. Systematics of flowering plants / Under. ed. db n D. D. Sokolov. St. Petersburg, Ed.: SPHFA 2015. Р. 189.
3. Kovalev N. V., Komarov V. L., Kostina K. F. et al. Flora of the USSR. V. 11. Legumes (first part) / ch. ed. Acad. V. L. Komarov. SPb.-M., Ed.: Academy of Sciences of the USSR. 1941. 675 p.
4. Kravchenko V. N., Georgiyancz V. A., Vladimirova I. N. Study of the effect of medicinal plants on the function of the thyroid gland // Bulletin of Vitebsk State Medical University. 2014. № 4. С. 149-154.
5. Ozimina I. I., Frolova O. O. On the issues of chemotaxonomy of the legume family // Basic research. 2013. № 4. Р. 873-882.
6. Palamarchuk A. S., Bondarenko V. E. Antimicrobial activity and chemical composition Drok dye // Rast. resources. 1976. № 12. Р. 229-232.
7. Plant resources of Russia. Wild flowering plants, their component composition and biological activity. V. 3. Families Fabaceae-Apiaceae / Ed. ed. A. L. Budantsev. SPb.-M., Association of scientific publications KMK. 2011. P. 608.
8. Cherepanov S. K. Vascular plants of Russia and neighboring countries (within the former USSR). SPb, Mir i sem’ya, 1995. 992 p.
9. Baali N., Belloum Z., Baali S. et al. Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats // Nutrients. 2016. V. 8(4). P. 193-200.
10. Batista D., Fale P. L., Serralheiro M. L et al. New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract // Nat. Prod. Bioprospect. 2015. V. 7(6). P. 155-158.
11. Bertoli A., Loi M. C., Pistelli L.et al. Volatile constituents as complementary tools to characterize seven Sardinian Genista species // Biochemical Systematics and Ecology. 2015. V. 62. P. 82-90.
12. Bisby F. A., Buckingham J., Harborne J. B. et al. Phytochemical dictionary of the Leguminosae. Chemical constituents. London. Chapman and Hall. 1994. V. 2. P. 573.
13. Chopin J., Bouillant M. L., Harborn J. B. et al. C-glycosylflavonoids. London, Chapman and Hall. 1975. 816 p.
14. Cubas P., Pardo C., Tahiri H. Molecular approach to the phylogeny and systematics of Cytisus (Leguminosae) and related genera based on nucleotide sequences of nrDNA (ITS region) and cpDNA (trnL-trnF intergenic spacer) // Plant Syst. Evol. 2002. V. 233. P. 223-242.
15. Faugeras G., Paris M. Sur les alcaloїdes des fruits du Genista pilosa L.: caractérisation par chromatografie en phase gazeuse isolement de la cytosine // Compt. Rend. Des séances Acad. Sci. Paris. 1964. V. 258(13). P. 3113-3116.
16. Gill S. Chromatografia cienkowarstwowa I bibuŁowa alkaloidơw chinolisydynowych w kilkugatuhkach z rodzaju Cytisus L. I Genista L. // Acta Poloniae Pharmaceutica. 1964.V. 4. P. 379-386.
17. Guettaf S., Abidli N., Kariche S. et al. Phytochemical screening and antioxidant activity of aqueous extract of Genista Saharae (Coss.&Dur.) // Der Pharmacia Lettre. 2016. V. 8(1). P. 50-60.
18. Hanganu D., Olah N. K., Benedec D. et al. Comparative polyphenolic content and antioxidant activities of Genista tinctoria L. and Genistella sagittalis (L.) Gams (Fabaceae) // Pakistan journal of pharmaceutical sciences. 2016. V. 29(1). P. 301-307.
19. Harborne J. B. Chemosystematics of the Leguminosae. Flavonoid and isoflavonoid patterns in the tribe Genistaea // Phytochemistry. 1969. V. 8. P. 1449-1456.
20. Ingham J. L., Lewis S. C., Bell T. D. et al. Naturally occurring isoflavonoids (18551981) // Fortschr. Chem. Org. Naturst. 1983. V. 23. P. 95-108.
21. Jagadeb M., Badirenath Konkimalla V., Rath S. N. et al. Elucidation of the Inhibitory Effect of Phytochemicals with Kir 6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach // Genomics inform. 2014. V. 12(4). P. 283-288.
22. Lograda T., Chaker A. N., Chalchat J. C. et al. Chemical composition and antimicrobial activity of essential oil of Genista ulicina Spach. and G. vepres Pomel.// Nat. Prod. Commun. 2010. V. 5(5). P. 835-838.
23. Mabberley D. J. The plant book. A portable dictionary of the higher plants. New York, New Rochelle, Mellbourne, Sydney. 1987. 706 p.
24. Pardo C., Cubas P., Tahiri H. Molecular phylogeny and systematic of Genista (Leguminosae) and related genera based on nucleotide sequences of nrDNA (ITS region) and cpDNA (trnL-trnF intergenic spacer) // Plant Syst. Evol. 2004. № 244. Р. 93-119.
25. Popa D. S., Bolfa P., Kiss B. et al. Influence of Genista tinctoria L. or methylparaben on subchronic toxicity of bisphenol A in rats // Biomedical and environmental sciences. 2014. V. 27(2). P. 85-96.
26. Rauter A. P., Martins A., Lopes R. et al. Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera // Journal of Ethnopharmacology. 2009. V. 122. P. 384-393.
27. Rigano D., Russo A., Formisano C. et al. Antiproliferative and cytotoxic effects on malignant melanoma cells of essential oils from the aerial parts of Genista sessilifolia and G. tinctoria // Nat. Prod. Commun. 2010. V. 5(7). P. 1127-1132.
28. Rizzi Longo L., Feoli Chiapella L., Cusma Velari T.et al. Pollen cards of some eastern taxa of Genista L. sect. Spartocarpus Spach. (Cytiseae, Fabaceae) // Atti Soc. tosc. Sci. nat. 2010. V. 117(5). P. 33-44.
29. Swain T. Flavonoids as chemotaxonomic markers in plants // Pigm. Plants. 1981. V. 7. P. 224-236.
30. Taberlet P., Gielly L., Patou G. et al. Universal primers for amplification of three non-coding regions of chloroplast DNA // Plant. Mol. Biol. 1991. № 17. Р. 1105-1109.
31. Tsypysheva. I. P., Petrova P. R., Baykova I. P. et al. Sesonal dynamics of alkaloids of Genista tinctoria L. growing at the Southern Ural Region // Natural Products. 2014. V. 10(7). P. 215-218.
32. Tůmová L., Tůma J. Dyer’s Greenweed (Genista tinctoria L.): constituents and biological activity // Ceska a Slovensca farmacie. 2011. V. 60(2). P. 61-64.
33. White T. J., Bruns T., Lee S. et al. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. USA, Academic Press. 1990. P. 586.
34. Yildimir A. B., Karakas F. P., Turker A. U. In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey // Asian Pacific journal of tropical medicine. 2013. V. 6(8). P. 616-624.
Review
For citations:
Zhokhova E.V., Protasova Y.A., Yakovlev G.P. PLANTS OF GENERA GENISTA L. AS PROMISING SOURCES OF PLANT RAW MATERIALS FOR THE CREATION OF NEW DRUG. Drug development & registration. 2018;(4):11-16. (In Russ.)
Views:
799
Email this article 