DISINTEGRANTS AND THEIR INFLUENCE ON THE DISSOLUTION OF SUBSTANCES OF BIOPHARMACEUTICAL CLASSIFICATION SYSTEM CLASSES
Abstract
The characteristic of disintegrants used in technology of solid dosage forms is reviewed. The effect on release of substances of different classes from the tablets according to the biopharmaceutical classification system is presented. The characteristic of disintegrants used in technology of solid dosage forms is reviewed. The mechanisms of their action and methods of compounding into tablets, as well as factors that must be considered when choosing the optimal disintegrant, are given. The results of studies on the effectiveness of various disintegrants (crospovidone, croscarmellose sodium, sodium starch glycollate, etc.) on the release of active substances of different classes according to the biopharmaceutical classification system from tablets are discussed. A promising use of co-disintegrating agents in the technology of tablets of substances of class II BCS is highlighted. Examples of disintegrants of natural origin (mucus) used in tablets dispersed in the oral cavity are given.
About the Authors
I. E. Smekhova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
V. A. Vainshtein
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Y. M. Ladutko
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
O. V. Druzhininskaya
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
N. N. Tureckova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
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Review
For citations:
Smekhova I.E., Vainshtein V.A., Ladutko Y.M., Druzhininskaya O.V., Tureckova N.N. DISINTEGRANTS AND THEIR INFLUENCE ON THE DISSOLUTION OF SUBSTANCES OF BIOPHARMACEUTICAL CLASSIFICATION SYSTEM CLASSES. Drug development & registration. 2018;(4):62-72. (In Russ.)
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